Onset and frequency of depression in post-COVID-19 syndrome: A systematic review
Following recovery from COVID-19, an increasing proportion of individuals have reported the persistence and/or new onset of symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health and Care Excellence. Although depressive symptoms in the acute p...
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| Vydané v: | Journal of psychiatric research Ročník 144; s. 129 - 137 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
England
Elsevier Ltd
01.12.2021
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| ISSN: | 0022-3956, 1879-1379, 1879-1379 |
| On-line prístup: | Získať plný text |
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| Abstract | Following recovery from COVID-19, an increasing proportion of individuals have reported the persistence and/or new onset of symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health and Care Excellence. Although depressive symptoms in the acute phase of COVID-19 have been well characterized, the frequency of depression following recovery of the acute phase remains unknown. Herein, we sought to determine the frequency of depressive symptoms and clinically-significant depression more than 12 weeks following SARS-CoV-2 infection. A systematic search of PubMed, Ovid Medline and Google Scholar for studies published between January 1, 2020 and June 5, 2021 was conducted. Frequency and factors associated with depression in post-COVID-19 syndrome were recorded and qualitatively assessed through narrative synthesis. Methodological quality and risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS) for prospective cohort studies. Of 316 articles identified through our systematic search, eight studies were included. The frequency of depressive symptoms +12 weeks following SARS-CoV-2 infection ranged from 11 to 28%. The frequency of clinically-significant depression and/or severe depressive symptoms ranged from 3 to 12%. The severity of acute COVID-19 was not associated with the frequency of depressive symptoms. However, the component studies were highly heterogeneous with respect to mode of ascertainment, time of assessment, and location and age of patients. The majority of studies did not include an unexposed control group. Future research should endeavour to produce a standardized classification of post-COVID-19 syndrome, and as well as include unexposed control groups. |
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| AbstractList | Following recovery from COVID-19, an increasing proportion of individuals have reported the persistence and/or new onset of symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health and Care Excellence. Although depressive symptoms in the acute phase of COVID-19 have been well characterized, the frequency of depression following recovery of the acute phase remains unknown. Herein, we sought to determine the frequency of depressive symptoms and clinically-significant depression more than 12 weeks following SARS-CoV-2 infection. A systematic search of PubMed, Ovid Medline and Google Scholar for studies published between January 1, 2020 and June 5, 2021 was conducted. Frequency and factors associated with depression in post-COVID-19 syndrome were recorded and qualitatively assessed through narrative synthesis. Methodological quality and risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS) for prospective cohort studies. Of 316 articles identified through our systematic search, eight studies were included. The frequency of depressive symptoms +12 weeks following SARS-CoV-2 infection ranged from 11 to 28%. The frequency of clinically-significant depression and/or severe depressive symptoms ranged from 3 to 12%. The severity of acute COVID-19 was not associated with the frequency of depressive symptoms. However, the component studies were highly heterogeneous with respect to mode of ascertainment, time of assessment, and location and age of patients. The majority of studies did not include an unexposed control group. Future research should endeavour to produce a standardized classification of post-COVID-19 syndrome, and as well as include unexposed control groups. Following recovery from COVID-19, an increasing proportion of individuals have reported the persistence and/or new onset of symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health and Care Excellence. Although depressive symptoms in the acute phase of COVID-19 have been well characterized, the frequency of depression following recovery of the acute phase remains unknown. Herein, we sought to determine the frequency of depressive symptoms and clinically-significant depression more than 12 weeks following SARS-CoV-2 infection. A systematic search of PubMed, Ovid Medline and Google Scholar for studies published between January 1, 2020 and June 5, 2021 was conducted. Frequency and factors associated with depression in post-COVID-19 syndrome were recorded and qualitatively assessed through narrative synthesis. Methodological quality and risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS) for prospective cohort studies. Of 316 articles identified through our systematic search, eight studies were included. The frequency of depressive symptoms +12 weeks following SARS-CoV-2 infection ranged from 11 to 28%. The frequency of clinically-significant depression and/or severe depressive symptoms ranged from 3 to 12%. The severity of acute COVID-19 was not associated with the frequency of depressive symptoms. However, the component studies were highly heterogeneous with respect to mode of ascertainment, time of assessment, and location and age of patients. The majority of studies did not include an unexposed control group. Future research should endeavour to produce a standardized classification of post-COVID-19 syndrome, and as well as include unexposed control groups.Following recovery from COVID-19, an increasing proportion of individuals have reported the persistence and/or new onset of symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health and Care Excellence. Although depressive symptoms in the acute phase of COVID-19 have been well characterized, the frequency of depression following recovery of the acute phase remains unknown. Herein, we sought to determine the frequency of depressive symptoms and clinically-significant depression more than 12 weeks following SARS-CoV-2 infection. A systematic search of PubMed, Ovid Medline and Google Scholar for studies published between January 1, 2020 and June 5, 2021 was conducted. Frequency and factors associated with depression in post-COVID-19 syndrome were recorded and qualitatively assessed through narrative synthesis. Methodological quality and risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS) for prospective cohort studies. Of 316 articles identified through our systematic search, eight studies were included. The frequency of depressive symptoms +12 weeks following SARS-CoV-2 infection ranged from 11 to 28%. The frequency of clinically-significant depression and/or severe depressive symptoms ranged from 3 to 12%. The severity of acute COVID-19 was not associated with the frequency of depressive symptoms. However, the component studies were highly heterogeneous with respect to mode of ascertainment, time of assessment, and location and age of patients. The majority of studies did not include an unexposed control group. Future research should endeavour to produce a standardized classification of post-COVID-19 syndrome, and as well as include unexposed control groups. |
| Author | Ceban, Felicia Lee, Yena Subramaniapillai, Mehala Renaud-Charest, Olivier Lui, Leanna M.W. McIntyre, Roger S. Eskander, Sherry Ho, Roger Di Vincenzo, Joshua D. Rosenblat, Joshua D. |
| Author_xml | – sequence: 1 givenname: Olivier surname: Renaud-Charest fullname: Renaud-Charest, Olivier organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 2 givenname: Leanna M.W. surname: Lui fullname: Lui, Leanna M.W. organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 3 givenname: Sherry orcidid: 0000-0002-9818-0753 surname: Eskander fullname: Eskander, Sherry organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 4 givenname: Felicia orcidid: 0000-0001-6815-7248 surname: Ceban fullname: Ceban, Felicia organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 5 givenname: Roger surname: Ho fullname: Ho, Roger organization: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore – sequence: 6 givenname: Joshua D. surname: Di Vincenzo fullname: Di Vincenzo, Joshua D. organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 7 givenname: Joshua D. surname: Rosenblat fullname: Rosenblat, Joshua D. organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 8 givenname: Yena surname: Lee fullname: Lee, Yena organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 9 givenname: Mehala surname: Subramaniapillai fullname: Subramaniapillai, Mehala organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada – sequence: 10 givenname: Roger S. orcidid: 0000-0003-4733-2523 surname: McIntyre fullname: McIntyre, Roger S. email: roger.mcintyre@uhn.ca organization: Mood Disorder Psychopharmacology Unit, University Health Network; University of Toronto, Toronto, ON, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34619491$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2021 Elsevier Ltd Copyright © 2021 Elsevier Ltd. All rights reserved. 2021 Elsevier Ltd. All rights reserved. 2021 Elsevier Ltd |
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| Keywords | COVID-19 Depression SARS-CoV-2 Post-acute sequelae of COVID-19 Post-COVID-19 syndrome Population health |
| Language | English |
| License | Copyright © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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