Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice

Mesenchymal stem cells (MSCs) mediate tissue repair and might be used to prevent or reduce liver fibrosis. However, little is known about the anti-fibrotic factors secreted from MSCs or their mechanisms. Umbilical cord-derived MSCs (UCMSCs) were differentiated into hepatocyte-like cells (hpUCMSCs),...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) Jg. 152; H. 5; S. 1174
Hauptverfasser:	An, Su Yeon, Jang, Yu Jin, Lim, Hee-Joung, Han, Jiyou, Lee, Jaehun, Lee, Gyunggyu, Park, Ji Young, Park, Seo-Young, Kim, Ji Hyang, Do, Byung-Rok, Han, Choongseong, Park, Hee-Kyung, Kim, Ok-Hee, Song, Myeong Jun, Kim, Say-June, Kim, Jong-Hoon
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2017
Schlagworte:	Animals Antigens, Surface - metabolism Carbon Tetrachloride - toxicity Cell Line Collagen - metabolism Extracellular Matrix - metabolism Hepatic Stellate Cells Hepatocytes Humans Integrin alphaVbeta3 - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mesenchymal Stromal Cells - secretion Metabolome Metalloproteases - metabolism Mice Milk Proteins - metabolism Receptors, Transforming Growth Factor beta - metabolism Smad2 Protein - metabolism Thioacetamide - toxicity Transforming Growth Factor beta1 - metabolism MMP Decorin Signal Transduction Mouse Model
ISSN:	1528-0012, 1528-0012
Online-Zugang:	Weitere Angaben
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