A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

Recent advances indicate that biological aging is a potentially modifiable driver of late-life function and chronic disease and have led to the development of geroscience-guided therapeutic trials such as TAME (Targeting Aging with MEtformin). TAME is a proposed randomized clinical trial using metfo...

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Bibliographic Details
Published in:	GeroScience Vol. 40; no. 5-6; pp. 419 - 436
Main Authors:	Justice, Jamie N., Ferrucci, Luigi, Newman, Anne B., Aroda, Vanita R., Bahnson, Judy L., Divers, Jasmin, Espeland, Mark A., Marcovina, Santica, Pollak, Michael N., Kritchevsky, Stephen B., Barzilai, Nir, Kuchel, George A.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.12.2018 Springer Nature B.V
Subjects:	Age differences Aging Aging - blood Antidiabetics Biological markers Biology Biomarkers Biomarkers - blood Biomedical and Life Sciences Biomedical Research Blood Candidates Cell Biology Chronic illnesses Clinical research Clinical trials Criteria Cystatin C Disease Feasibility Frame analysis Functional impairment Geriatrics/Gerontology Hemoglobin Humans Hypoglycemic Agents - therapeutic use Insulin Insulin-like growth factor I Interleukin 6 Intervention Life Sciences Literature Literature reviews Measurement Medical diagnosis Metformin Metformin - therapeutic use Molecular Medicine Morbidity Randomized Controlled Trials as Topic Reliability Reproducibility of Results Responsiveness Review Review Article Scarcity Selection criteria Tumor necrosis factor-α Mortality Biomarkers Aging Inflammation Metformin Randomized controlled trial Epidemiology
ISSN:	2509-2715, 2509-2723, 2509-2723
Online Access:	Get full text
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