Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with la...

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Veröffentlicht in:	British journal of cancer Jg. 119; H. 6; S. 693 - 696
Hauptverfasser:	Ziegler, David S., Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J., Lau, Loretta M. S., Reynolds, Mark, Cox, Michael C., Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Haber, Michelle
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.09.2018 Nature Publishing Group
Schlagworte:	631/67/1059/602 631/67/1922 Babies Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Brain research Brief Communication Cancer Research Cancer therapies Chemotherapy Child, Preschool Drug Resistance Epidemiology Female Fibrosarcoma Genomes Genomics Glioma Glioma - diagnostic imaging Glioma - drug therapy Glioma - genetics Glioma - pathology Hospitals Humans Magnetic Resonance Imaging Medical research Metastases Metastasis Molecular Medicine Neoplasm Grading Oncogene Proteins, Fusion - genetics Oncology Papillary thyroid cancer Patients Pediatrics Pyrazoles - administration & dosage Pyrazoles - therapeutic use Pyrimidines - administration & dosage Pyrimidines - therapeutic use Radiation therapy Thyroid cancer Treatment Outcome Tumorigenesis Tumors Vomiting Whole Genome Sequencing
ISSN:	0007-0920, 1532-1827, 1532-1827
Online-Zugang:	Volltext
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