Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with la...

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Bibliographic Details
Published in:	British journal of cancer Vol. 119; no. 6; pp. 693 - 696
Main Authors:	Ziegler, David S, Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J, Lau, Loretta M S, Reynolds, Mark, Cox, Michael C, Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J, Ekert, Paul G, Marshall, Glenn M, Haber, Michelle
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 11.09.2018
Subjects:	Babies Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Brain research Cancer therapies Chemotherapy Child, Preschool Female Fibrosarcoma Genomes Genomics Glioma Glioma - diagnostic imaging Glioma - drug therapy Glioma - genetics Glioma - pathology Hospitals Humans Magnetic Resonance Imaging Medical research Metastases Metastasis Neoplasm Grading Oncogene Proteins, Fusion - genetics Papillary thyroid cancer Patients Pediatrics Pyrazoles - administration & dosage Pyrazoles - therapeutic use Pyrimidines - administration & dosage Pyrimidines - therapeutic use Radiation therapy Thyroid cancer Treatment Outcome Tumorigenesis Tumors Vomiting Whole Genome Sequencing
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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