A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010

Chronic kidney disease (CKD) is a major risk factor for endstage renal disease, cardiovascular disease, and premature death. Here we estimated the global prevalence and absolute burden of CKD in 2010 by pooling data from population- based studies. We searched MEDLINE (January 1990 to December 2014),...

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Vydáno v:Kidney international Ročník 88; číslo 5; s. 950 - 957
Hlavní autoři: Mills, Katherine T., Xu, Yu, Zhang, Weidong, Bundy, Joshua D., Chen, Chung-Shiuan, Kelly, Tanika N., Chen, Jing, He, Jiang
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.11.2015
Elsevier Limited
Témata:
chronic kidney disease
Developed Countries - statistics & numerical data
Developing Countries - statistics & numerical data
Female
Global Health - statistics & numerical data
Humans
Male
Prevalence
proteinuria
Renal Insufficiency, Chronic - epidemiology
prevalence
chronic kidney disease
proteinuria
ISSN:0085-2538, 1523-1755, 1523-1755
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Shrnutí:Chronic kidney disease (CKD) is a major risk factor for endstage renal disease, cardiovascular disease, and premature death. Here we estimated the global prevalence and absolute burden of CKD in 2010 by pooling data from population- based studies. We searched MEDLINE (January 1990 to December 2014), International Society of Nephrology Global Outreach Program-funded projects, and bibliographies of retrieved articles and selected 33 studies reporting gender- and age-specific prevalence of CKD in representative population samples. The age-standardized global prevalence of CKD stages 1–5 in adults aged 20 and older was 10.4% in men (95% confidence interval 9.3–11.9%) and 11.8% in women (11.2–12.6%). This consisted of 8.6% in men (7.3–9.8%) and 9.6% in women (7.7–11.1%) in high-income countries, and 10.6% in men (9.4–13.1%) and 12.5% in women (11.8–14.0%) in low- and middle-income countries. The total number of adults with CKD was 225.7 million (205.7–257.4 million) men and 271.8 million (258.0–293.7 million) women. This consisted of 48.3 million (42.3–53.3 million) men and 61.7 million (50.4–69.9 million) women in high-income countries, and 177.4 million (159.2–215.9 million) men and 210.1 million (200.8–231.7 million) women in low- and middle-income countries. Thus, CKD is an important global-health challenge, especially in low- and middle-income countries. National and international efforts for prevention, detection, and treatment of CKD are needed to reduce its morbidity and mortality worldwide.
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ISSN:0085-2538
1523-1755
1523-1755
DOI:10.1038/ki.2015.230