Structures of the human spliceosomes before and after release of the ligated exon

Pre-mRNA splicing is executed by the spliceosome, which has eight major functional states each with distinct composition. Five of these eight human spliceosomal complexes, all preceding exon ligation, have been structurally characterized. In this study, we report the cryo-electron microscopy structu...

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Bibliographic Details
Published in:	Cell research Vol. 29; no. 4; pp. 274 - 285
Main Authors:	Zhang, Xiaofeng, Zhan, Xiechao, Yan, Chuangye, Zhang, Wenyu, Liu, Dongliang, Lei, Jianlin, Shi, Yigong
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2019
Subjects:	Adenosine triphosphatase Adenosine Triphosphatases - metabolism Catalysis DEAD-box RNA Helicases - metabolism Dismantling DNA helicase Electron microscopy Models, Molecular mRNA Proteins Ribonucleic acid RNA RNA Helicases - metabolism RNA Precursors - metabolism RNA Splicing RNA Splicing Factors - metabolism RNA, Small Nuclear - metabolism snRNA Spliceosomes Spliceosomes - metabolism Splicing
ISSN:	1001-0602, 1748-7838, 1748-7838
Online Access:	Get full text
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