Structures of the human spliceosomes before and after release of the ligated exon

Pre-mRNA splicing is executed by the spliceosome, which has eight major functional states each with distinct composition. Five of these eight human spliceosomal complexes, all preceding exon ligation, have been structurally characterized. In this study, we report the cryo-electron microscopy structu...

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Vydáno v:	Cell research Ročník 29; číslo 4; s. 274 - 285
Hlavní autoři:	Zhang, Xiaofeng, Zhan, Xiechao, Yan, Chuangye, Zhang, Wenyu, Liu, Dongliang, Lei, Jianlin, Shi, Yigong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.04.2019
Témata:	Adenosine triphosphatase Adenosine Triphosphatases - metabolism Catalysis DEAD-box RNA Helicases - metabolism Dismantling DNA helicase Electron microscopy Models, Molecular mRNA Proteins Ribonucleic acid RNA RNA Helicases - metabolism RNA Precursors - metabolism RNA Splicing RNA Splicing Factors - metabolism RNA, Small Nuclear - metabolism snRNA Spliceosomes Spliceosomes - metabolism Splicing
ISSN:	1001-0602, 1748-7838, 1748-7838
On-line přístup:	Získat plný text
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