Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study

Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COV...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of psychiatric research Vol. 150; pp. 40 - 46
Main Authors:	Delgado-Alonso, Cristina, Valles-Salgado, Maria, Delgado-Álvarez, Alfonso, Yus, Miguel, Gómez-Ruiz, Natividad, Jorquera, Manuela, Polidura, Carmen, Gil, María José, Marcos, Alberto, Matías-Guiu, Jorge, Matías-Guiu, Jordi A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2022
Subjects:	Cognition - physiology Cognitive Cognitive Dysfunction - etiology Cognitive Dysfunction - psychology COVID-19 COVID-19 - complications Cross-Sectional Studies Executive Function - physiology Humans Long-term COVID Neuropsychological assessment Neuropsychological Tests Post-Acute COVID-19 Syndrome COVID-19 Cognitive Neuropsychological assessment Long-term COVID
ISSN:	0022-3956, 1879-1379, 1879-1379
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function. Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison. COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression. Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.
AbstractList	Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function. Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison. COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression. Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction. Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function.OBJECTIVERecent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function.Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison.METHODSCross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison.COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression.RESULTSCOVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression.Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.CONCLUSIONSPatients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.
Author	Polidura, Carmen Matías-Guiu, Jordi A. Jorquera, Manuela Gil, María José Yus, Miguel Delgado-Álvarez, Alfonso Delgado-Alonso, Cristina Valles-Salgado, Maria Marcos, Alberto Matías-Guiu, Jorge Gómez-Ruiz, Natividad
Author_xml	– sequence: 1 givenname: Cristina surname: Delgado-Alonso fullname: Delgado-Alonso, Cristina organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 2 givenname: Maria surname: Valles-Salgado fullname: Valles-Salgado, Maria organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 3 givenname: Alfonso surname: Delgado-Álvarez fullname: Delgado-Álvarez, Alfonso organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 4 givenname: Miguel orcidid: 0000-0003-3191-6743 surname: Yus fullname: Yus, Miguel organization: Department of Radiology, Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 5 givenname: Natividad surname: Gómez-Ruiz fullname: Gómez-Ruiz, Natividad organization: Department of Radiology, Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 6 givenname: Manuela orcidid: 0000-0002-4920-0359 surname: Jorquera fullname: Jorquera, Manuela organization: Department of Radiology, Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 7 givenname: Carmen surname: Polidura fullname: Polidura, Carmen organization: Department of Radiology, Clinico San Carlos, Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 8 givenname: María José surname: Gil fullname: Gil, María José organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 9 givenname: Alberto surname: Marcos fullname: Marcos, Alberto organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 10 givenname: Jorge surname: Matías-Guiu fullname: Matías-Guiu, Jorge organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain – sequence: 11 givenname: Jordi A. surname: Matías-Guiu fullname: Matías-Guiu, Jordi A. email: jordi.matias-guiu@salud.madrid.org organization: Department of Neurology, Hospital Clínico San Carlos. Health Research Institute “San Carlos” (IdISCC), Universidad Complutense de Madrid, Madrid, Spain
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35349797$$D View this record in MEDLINE/PubMed
BookMark	eNqNkUFvEzEQhS3UiqaFv4D2yGVTe22v1xwQJRRaqVIvFeJmOfYkcdjYwfYG7b9nl5S05RRpJB_mzTfj987RiQ8eECoInhJM6sv1dL1NvVm5CGla4aqaYjoUfYUmpBGyJFTIEzTBQ6ekktdn6DylNcZYVIS9RmeUUyaFFBP0YxaW3mW3g8L2adF5k13whU4pGKcz2OK3y6tidv_99ktJ5IfiqjBhs42wAp_GKQ9dDH-PCW1YOqPbIuXO9m_Q6UK3Cd4-vhfo4ev1w-ymvLv_dju7uisNp3UurdW24dhKLjWruKjn3OCKE91oqzEQLjAThjSc2UbauWBAsME1bWpcG0roBfq4x267-QasAZ-jbtU2uo2OvQraqZcd71ZqGXaqkYyySg6A94-AGH51kLLauGSgbbWH0CVV1YwzMTo5SN8933VY8s_NQdDsBSaGlCIsDhKC1RicWqun4NQYnMJ0KPr0j8OocVmPWQxXu_YYwOc9AAazdw6iSsaBN2AHqcnKBncM5NN_ENM6P4b6E_rjEH8A5zvTaA
CitedBy_id	crossref_primary_10_1038_s41598_025_04166_2 crossref_primary_10_1016_j_jbct_2025_100534 crossref_primary_10_1080_23279095_2025_2496748 crossref_primary_10_1371_journal_pone_0312735 crossref_primary_10_1371_journal_pone_0322304 crossref_primary_10_1093_biomethods_bpad037 crossref_primary_10_1080_13854046_2024_2392943 crossref_primary_10_20473_jcmphr_v5i2_53392 crossref_primary_10_3390_ejihpe14120197 crossref_primary_10_1007_s00115_022_01297_z crossref_primary_10_3390_jcm11133886 crossref_primary_10_1016_j_dr_2023_101104 crossref_primary_10_1016_j_nrl_2023_05_005 crossref_primary_10_1007_s00415_023_11587_4 crossref_primary_10_1111_1460_6984_13118 crossref_primary_10_3389_fnins_2023_1161904 crossref_primary_10_3390_healthcare10101891 crossref_primary_10_1080_13854046_2024_2379508 crossref_primary_10_1016_j_nrleng_2022_06_007 crossref_primary_10_3390_jcm13061753 crossref_primary_10_1111_ene_16084 crossref_primary_10_1371_journal_pone_0312351 crossref_primary_10_1111_irv_13197 crossref_primary_10_1186_s13024_024_00728_6 crossref_primary_10_1007_s40211_023_00487_8 crossref_primary_10_3389_fpsyg_2024_1441018 crossref_primary_10_3390_biom14010008 crossref_primary_10_3390_ijerph192013368 crossref_primary_10_1001_jamanetworkopen_2023_11974 crossref_primary_10_3389_fpsyt_2023_1272812 crossref_primary_10_3389_fnins_2023_1198267 crossref_primary_10_1016_j_compbiomed_2023_107906 crossref_primary_10_3390_ejihpe13020038 crossref_primary_10_3390_ijerph20064889 crossref_primary_10_1016_j_neubiorev_2025_106067 crossref_primary_10_1016_j_bbr_2024_115095 crossref_primary_10_1371_journal_pmed_1004511 crossref_primary_10_1016_j_neuint_2024_105723 crossref_primary_10_1016_j_cct_2022_106955 crossref_primary_10_1016_j_jocn_2022_09_006 crossref_primary_10_1186_s12916_023_02952_1 crossref_primary_10_1038_s41591_024_03309_8 crossref_primary_10_26876_uztaro5109 crossref_primary_10_1093_arclin_acae042 crossref_primary_10_1007_s00406_025_02116_7 crossref_primary_10_3389_fnins_2023_1164042 crossref_primary_10_1016_j_bbih_2024_100917 crossref_primary_10_1080_13854046_2024_2344455 crossref_primary_10_1177_26331055231186998 crossref_primary_10_3389_fneur_2024_1486751 crossref_primary_10_1055_a_1899_6572 crossref_primary_10_1093_brain_awae101 crossref_primary_10_1016_j_tics_2023_08_008 crossref_primary_10_1055_a_1967_9350 crossref_primary_10_1038_s41598_023_32939_0 crossref_primary_10_1016_j_arrct_2025_100461 crossref_primary_10_1044_2023_AJSLP_23_00157 crossref_primary_10_1080_23279095_2025_2502871 crossref_primary_10_1093_arclin_acaf082 crossref_primary_10_1007_s10072_023_06884_9 crossref_primary_10_1016_j_nrleng_2025_05_002 crossref_primary_10_1038_s41380_022_01797_z crossref_primary_10_1016_j_lanwpc_2023_100836 crossref_primary_10_1080_13854046_2025_2496212 crossref_primary_10_3389_fpsyg_2023_1165911 crossref_primary_10_1002_acn3_51952 crossref_primary_10_1016_j_bbih_2023_100721 crossref_primary_10_1177_25424823241284500 crossref_primary_10_3389_fspor_2024_1493729 crossref_primary_10_1038_s41598_025_09772_8 crossref_primary_10_3389_fnagi_2022_1029842 crossref_primary_10_1038_s41598_024_63071_2 crossref_primary_10_1192_j_eurpsy_2023_25 crossref_primary_10_1016_j_psychres_2022_115006 crossref_primary_10_3390_brainsci12060714 crossref_primary_10_3389_fneur_2024_1334161 crossref_primary_10_1016_j_jpsychires_2024_06_036 crossref_primary_10_3390_jcm14030952 crossref_primary_10_1016_j_bbr_2024_115127 crossref_primary_10_1007_s10311_025_01870_3 crossref_primary_10_1016_j_ibneur_2025_06_003 crossref_primary_10_3389_fneur_2024_1426881 crossref_primary_10_3390_brainsci13121670 crossref_primary_10_1080_23279095_2025_2454352 crossref_primary_10_1093_brain_awac384 crossref_primary_10_1136_bmj_2023_075387 crossref_primary_10_1016_j_ebiom_2023_104711 crossref_primary_10_3390_jcm14092911 crossref_primary_10_1097_MS9_0000000000001265 crossref_primary_10_1002_brb3_70603 crossref_primary_10_1016_j_apmr_2025_09_002 crossref_primary_10_2196_71303 crossref_primary_10_1093_arclin_acaf064 crossref_primary_10_3390_brainsci14060587 crossref_primary_10_3389_fnins_2022_1082811 crossref_primary_10_3389_fpsyg_2023_1076743 crossref_primary_10_1007_s00406_023_01748_x crossref_primary_10_3390_ijms242216394 crossref_primary_10_1093_arclin_acae017 crossref_primary_10_3389_fmed_2024_1399145 crossref_primary_10_3389_fneur_2023_1093852 crossref_primary_10_7759_cureus_58929 crossref_primary_10_1371_journal_pone_0297207 crossref_primary_10_3390_neurolint15030052 crossref_primary_10_1016_j_lfs_2024_123068 crossref_primary_10_1177_26331055251342755 crossref_primary_10_1038_s41598_024_60368_0 crossref_primary_10_3390_brainsci13121611 crossref_primary_10_1080_07853890_2025_2453082 crossref_primary_10_3390_oral3010008 crossref_primary_10_3389_fneur_2024_1419134 crossref_primary_10_1111_ene_16181
Cites_doi	10.1016/0165-1781(89)90047-4 10.1038/s41590-021-01104-y 10.1191/1352458505ms1117oa 10.1016/j.msard.2020.102070 10.1024/1016-264X/a000013 10.1016/j.jns.2022.120162 10.1016/j.jpsychires.2020.06.022 10.1016/0272-7358(88)90050-5 10.1093/arclin/acp027 10.1016/j.msard.2020.102576 10.1016/j.eclinm.2020.100683 10.1097/YCO.0000000000000713 10.1093/brain/awab302 10.5664/jcsm.27351 10.1097/00005537-199603000-00021 10.1016/j.nrl.2011.12.019 10.1093/braincomms/fcaa205 10.1016/j.jad.2021.01.084 10.3233/JAD-132186
ContentType	Journal Article
Copyright	2022 Elsevier Ltd Copyright © 2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd
Copyright_xml	– notice: 2022 Elsevier Ltd – notice: Copyright © 2022 Elsevier Ltd. All rights reserved. – notice: 2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
DOI	10.1016/j.jpsychires.2022.03.033
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1879-1379
EndPage	46
ExternalDocumentID	PMC8943429 35349797 10_1016_j_jpsychires_2022_03_033 S0022395622001625
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABIVO ABJNI ABLJU ABMAC ABMZM ABOYX ABPPZ ABWVN ABXDB ACDAQ ACGFS ACHQT ACIEU ACIUM ACLOT ACNCT ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO ADXHL AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HF~ HMK HMO HMQ HMW HVGLF HZ~ IHE J1W K-O KOM L7B M29 M2V M39 M3V M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SPS SSB SSH SSN SSY SSZ T5K WUQ YQT Z5R ZGI ~G- ~HD AACTN AADPK AAIAV ABLVK ABYKQ AFCTW AFKWA AFYLN AJBFU AJOXV AMFUW LCYCR RIG ZA5 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM PKN 7X8 5PM
ID	FETCH-LOGICAL-c536t-ddad850d959a42576b5c0251a8ada0e157047c1854d89db74e10c0638606c313
ISICitedReferencesCount	131
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000792888700006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0022-3956 1879-1379
IngestDate	Tue Sep 30 16:50:58 EDT 2025 Sat Sep 27 19:11:40 EDT 2025 Wed Feb 19 02:25:51 EST 2025 Tue Nov 18 21:45:36 EST 2025 Sat Nov 29 07:30:03 EST 2025 Fri Feb 23 02:39:59 EST 2024 Tue Oct 14 19:35:58 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	COVID-19 Cognitive Neuropsychological assessment Long-term COVID
Language	English
License	Copyright © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c536t-ddad850d959a42576b5c0251a8ada0e157047c1854d89db74e10c0638606c313
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0003-3191-6743 0000-0002-4920-0359
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC8943429
PMID	35349797
PQID	2645470022
PQPubID	23479
PageCount	7
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_8943429 proquest_miscellaneous_2645470022 pubmed_primary_35349797 crossref_primary_10_1016_j_jpsychires_2022_03_033 crossref_citationtrail_10_1016_j_jpsychires_2022_03_033 elsevier_sciencedirect_doi_10_1016_j_jpsychires_2022_03_033 elsevier_clinicalkey_doi_10_1016_j_jpsychires_2022_03_033
PublicationCentury	2000
PublicationDate	2022-06-01
PublicationDateYYYYMMDD	2022-06-01
PublicationDate_xml	– month: 06 year: 2022 text: 2022-06-01 day: 01
PublicationDecade	2020
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Journal of psychiatric research
PublicationTitleAlternate	J Psychiatr Res
PublicationYear	2022
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Beblo, Kunz, Brokate, Scheurich, Weber, Albert, Richter, Lautenbacher (bib3) 2010; 21 Balcom, Nath, Power (bib2) 2021; 144 Doty, Marcus, Lee (bib8) 1996; 6 Vanderlind, Rabinovitz, Miao, Oberlin, Bueno-Castellano, Fridman, Jaywant, Kanellopoulos (bib23) 2021; 34 Mehandru, Merad (bib14) 2022; 23 Raman, Cassar, Tunnicliffe, Filippini, Griffanti, Alfaro-Almagro, Okell, Sheerin (bib19) 2021; 31 Beck, Steer, Garbin (bib4) 1988; 8 Peña-Casanova, Blesa, Aguilar, Gramunt-Fombuena, Gómez-Ansón, Oliva, Molinuevo, Robles, Barquero, Antúnez, Martínez Parra, Frank-García, Fernández, Alfonso, Sol, NEURONORMA Study Team (bib16) 2009; 24 Woo, Malsy, Pöttgen, Seddiq Zai, Ufer, Hadjilaou, Schmiedel, Addo, Gerloff, Heesen, Schulze Zur Wiesch, Friese (bib24) 2020; 2 Buysse, Reynolds, Monk, Berman, Kupfer (bib6) 1989; 28 Aschenbrenner, Kaiser, Pfüller, Roesch-Ely, Weisbrod (bib1) 2012 Sánchez-Benavides, Peña-Casanova, Casals-Coll, Gramunt, Molinuevo, Gómez-Ansón, Aguilar, Robles, Antúnez, Martínez-Parra, Frank-García, Fernández-Martínez, Blesa, NEURONORMA Study Team (bib20) 2014; 41 Hewitt, Marra, Block, Cysique, Drane, Haddad, Lojek, McDonald, Reyes, Eversole, Bowers (bib9) 2021; 1 Kos, Kerckhofs, Carrea, Verza, Ramos, Jansa (bib10) 2005; 11 Matias-Guiu, Gómez-Pinedo, Montero-Escribano, Gómez-Iglesias, Porta-Etessam, Matías-Guiu (bib12) 2020; 35 McDonald, Busch, Reyes, Arotta, Barr, Block, Hessen, Loring, Drane, Hamberger, Wilson, Baxendale, Hermann (bib13) 2022 Buysse, Hall, Strollo, Kamarck, Owens, Lee, Reis, Matthews (bib7) 2008; 4 Beck, Steer, Brown (bib5) 1996 Matias-Guiu, Sánchez-Benavides, Rivera-Àvila, Cortés-Martínez, Delgado-Alonso, Delgado-Álvarez, Montero, Pytel, Matías-Guiu, Peña-Casanova (bib11) 2020; 42 World Health Organization (bib25) 6 October 2021 Premraj, Kannapadi, Briggs, Seal, Battaglini, Fanning, Suen, Robba, Fraser, Cho (bib18) 2022; 434 Peña-Casanova, Casals-Coll, Quintana, Sánchez-Benavides, Rognoni, Calvo, Palomo, Aranciva, Tamayo, Manero (bib17) 2012; 27 Strober, Bruce, Arnett, Alschulet, DeLuca, Chiaravalloti, Lebkuechr, Di Benedetto, Cozart, Thelen, Guty, Román (bib22) 2020; 46 Spielberger, Gorsuch, Lushene, Vagg, Jacobs (bib21) 1983 Zhou, Lu, Chen, Wei, Wang, Lyu, Shi, Hu (bib26) 2020; 129 Nikolin, Tan, Schwaab, Moffa, Loo, Martin (bib15) 2021; 284 Raman (10.1016/j.jpsychires.2022.03.033_bib19) 2021; 31 Buysse (10.1016/j.jpsychires.2022.03.033_bib7) 2008; 4 Woo (10.1016/j.jpsychires.2022.03.033_bib24) 2020; 2 Hewitt (10.1016/j.jpsychires.2022.03.033_bib9) 2021; 1 Strober (10.1016/j.jpsychires.2022.03.033_bib22) 2020; 46 Sánchez-Benavides (10.1016/j.jpsychires.2022.03.033_bib20) 2014; 41 Mehandru (10.1016/j.jpsychires.2022.03.033_bib14) 2022; 23 Peña-Casanova (10.1016/j.jpsychires.2022.03.033_bib17) 2012; 27 Premraj (10.1016/j.jpsychires.2022.03.033_bib18) 2022; 434 McDonald (10.1016/j.jpsychires.2022.03.033_bib13) 2022 Kos (10.1016/j.jpsychires.2022.03.033_bib10) 2005; 11 Beck (10.1016/j.jpsychires.2022.03.033_bib4) 1988; 8 Beck (10.1016/j.jpsychires.2022.03.033_bib5) 1996 Doty (10.1016/j.jpsychires.2022.03.033_bib8) 1996; 6 Peña-Casanova (10.1016/j.jpsychires.2022.03.033_bib16) 2009; 24 Nikolin (10.1016/j.jpsychires.2022.03.033_bib15) 2021; 284 Beblo (10.1016/j.jpsychires.2022.03.033_bib3) 2010; 21 Zhou (10.1016/j.jpsychires.2022.03.033_bib26) 2020; 129 World Health Organization (10.1016/j.jpsychires.2022.03.033_bib25) 2021 Buysse (10.1016/j.jpsychires.2022.03.033_bib6) 1989; 28 Matias-Guiu (10.1016/j.jpsychires.2022.03.033_bib12) 2020; 35 Vanderlind (10.1016/j.jpsychires.2022.03.033_bib23) 2021; 34 Matias-Guiu (10.1016/j.jpsychires.2022.03.033_bib11) 2020; 42 Spielberger (10.1016/j.jpsychires.2022.03.033_bib21) 1983 Balcom (10.1016/j.jpsychires.2022.03.033_bib2) 2021; 144 Aschenbrenner (10.1016/j.jpsychires.2022.03.033_bib1) 2012
References_xml	– volume: 41 start-page: 887 year: 2014 end-page: 901 ident: bib20 article-title: Cognitive and neuroimaging profiles in mild cognitive impairment and Alzheimer's disease: data from the Spanish Multicenter Normative Studies (NEURONORMA Project) publication-title: J. Alzheimers Dis. – year: 1996 ident: bib5 article-title: BDI-II. Beck Depression Inventory – volume: 284 start-page: 1 year: 2021 end-page: 8 ident: bib15 article-title: An investigation of working memory deficits in depression using the n-back task: a systematic review and meta-analysis publication-title: J. Affect. Disord. – volume: 24 start-page: 307 year: 2009 end-page: 319 ident: bib16 article-title: Spanish multicenter normative studies (NEURONORMA Project): methods and sample characteristics publication-title: Arch. Clin. Neuropsychol. – volume: 2 year: 2020 ident: bib24 article-title: Frequent neurocognitive deficits after recovery from COVID-19 publication-title: Brain Commun. – volume: 1 start-page: 15 year: 2021 ident: bib9 article-title: Central nervous system manifestations of COVID-19: a critical review and proposed research agenda publication-title: J. Int. Neuropsychol. Soc. – volume: 27 start-page: 253 year: 2012 end-page: 260 ident: bib17 article-title: Spanish normative studies in a young adult population (NEURONORMA young adults Project): methods and characteristics of the sample publication-title: Neurologia – volume: 144 start-page: 3576 year: 2021 end-page: 3588 ident: bib2 article-title: Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease publication-title: Brain – volume: 34 start-page: 420 year: 2021 end-page: 433 ident: bib23 article-title: A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment publication-title: Curr. Opin. Psychiatr. – volume: 23 start-page: 194 year: 2022 end-page: 202 ident: bib14 article-title: Pathological sequelae of long-haul COVID publication-title: Nat. Immunol. – volume: 8 start-page: 77 year: 1988 end-page: 100 ident: bib4 article-title: Psychometric properties of the Beck depression inventory: twenty-five years of evaluation publication-title: Clin. Psychol. Rev. – year: 6 October 2021 ident: bib25 article-title: A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus – volume: 129 start-page: 98 year: 2020 end-page: 102 ident: bib26 article-title: The landscape of cognitive function in recovered COVID-19 patients publication-title: J. Psychiatr. Res. – volume: 46 start-page: 102576 year: 2020 ident: bib22 article-title: Tired of not knowing what fatigue score means? Normative data of the Modified Fatigue Impact Scale (MFIS) publication-title: Mult. Scler. Relat. Disord. – volume: 6 start-page: 353 year: 1996 end-page: 356 ident: bib8 article-title: Development of the 12-item cross-cultural Smell identification test (CC-sit) publication-title: Laryngoscope – volume: 11 start-page: 76 year: 2005 end-page: 80 ident: bib10 article-title: Evaluation of the modified fatigue impact scale in four different European countries publication-title: Mult. Scler. – volume: 21 start-page: 143 year: 2010 end-page: 151 ident: bib3 article-title: Entwicklung eines Fragebogens zur subjektiven Einschaätzung der geistigen Leistungsfahigkeit (FLei) bei Patienten mit psychischen Störungen publication-title: Z. für Neuropsychol. – volume: 31 start-page: 100683 year: 2021 ident: bib19 article-title: Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, posthospital discharge publication-title: EClinicalMed. – year: 2022 ident: bib13 article-title: For the IC-CoDE task force publication-title: Neuropsychology – year: 1983 ident: bib21 article-title: Manual for the State-Trait Anxiety Inventory – volume: 42 start-page: 102070 year: 2020 ident: bib11 article-title: Validation of the Neuronorma battery for neuropsychological assessment in multiple sclerosis publication-title: Mult. Scler. Relat. Disor. – volume: 35 start-page: 170 year: 2020 end-page: 175 ident: bib12 article-title: Should we expect neurological symptoms in the SARS-CoV-2 epidemic? publication-title: Neurologia – volume: 28 start-page: 193 year: 1989 end-page: 213 ident: bib6 article-title: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research publication-title: Psychiatr. Res. – volume: 434 start-page: 120162 year: 2022 ident: bib18 article-title: Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis publication-title: J. Neurol. Sci. – year: 2012 ident: bib1 article-title: Testset COGBAT – volume: 4 start-page: 563 year: 2008 end-page: 571 ident: bib7 article-title: Relationships between the Pittsburgh sleep quality Index (PSQI), epworth sleepiness scale (ESS), and clinical/polysomnographic measures in a community sample publication-title: J. Clin. Sleep Med. – volume: 28 start-page: 193 year: 1989 ident: 10.1016/j.jpsychires.2022.03.033_bib6 article-title: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research publication-title: Psychiatr. Res. doi: 10.1016/0165-1781(89)90047-4 – volume: 23 start-page: 194 year: 2022 ident: 10.1016/j.jpsychires.2022.03.033_bib14 article-title: Pathological sequelae of long-haul COVID publication-title: Nat. Immunol. doi: 10.1038/s41590-021-01104-y – volume: 11 start-page: 76 year: 2005 ident: 10.1016/j.jpsychires.2022.03.033_bib10 article-title: Evaluation of the modified fatigue impact scale in four different European countries publication-title: Mult. Scler. doi: 10.1191/1352458505ms1117oa – volume: 42 start-page: 102070 year: 2020 ident: 10.1016/j.jpsychires.2022.03.033_bib11 article-title: Validation of the Neuronorma battery for neuropsychological assessment in multiple sclerosis publication-title: Mult. Scler. Relat. Disor. doi: 10.1016/j.msard.2020.102070 – volume: 21 start-page: 143 year: 2010 ident: 10.1016/j.jpsychires.2022.03.033_bib3 article-title: Entwicklung eines Fragebogens zur subjektiven Einschaätzung der geistigen Leistungsfahigkeit (FLei) bei Patienten mit psychischen Störungen publication-title: Z. für Neuropsychol. doi: 10.1024/1016-264X/a000013 – year: 1996 ident: 10.1016/j.jpsychires.2022.03.033_bib5 – volume: 35 start-page: 170 year: 2020 ident: 10.1016/j.jpsychires.2022.03.033_bib12 article-title: Should we expect neurological symptoms in the SARS-CoV-2 epidemic? publication-title: Neurologia – year: 2012 ident: 10.1016/j.jpsychires.2022.03.033_bib1 – volume: 434 start-page: 120162 year: 2022 ident: 10.1016/j.jpsychires.2022.03.033_bib18 article-title: Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2022.120162 – volume: 129 start-page: 98 year: 2020 ident: 10.1016/j.jpsychires.2022.03.033_bib26 article-title: The landscape of cognitive function in recovered COVID-19 patients publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2020.06.022 – volume: 8 start-page: 77 year: 1988 ident: 10.1016/j.jpsychires.2022.03.033_bib4 article-title: Psychometric properties of the Beck depression inventory: twenty-five years of evaluation publication-title: Clin. Psychol. Rev. doi: 10.1016/0272-7358(88)90050-5 – volume: 24 start-page: 307 year: 2009 ident: 10.1016/j.jpsychires.2022.03.033_bib16 article-title: Spanish multicenter normative studies (NEURONORMA Project): methods and sample characteristics publication-title: Arch. Clin. Neuropsychol. doi: 10.1093/arclin/acp027 – year: 1983 ident: 10.1016/j.jpsychires.2022.03.033_bib21 – volume: 46 start-page: 102576 year: 2020 ident: 10.1016/j.jpsychires.2022.03.033_bib22 article-title: Tired of not knowing what fatigue score means? Normative data of the Modified Fatigue Impact Scale (MFIS) publication-title: Mult. Scler. Relat. Disord. doi: 10.1016/j.msard.2020.102576 – volume: 31 start-page: 100683 year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib19 article-title: Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, posthospital discharge publication-title: EClinicalMed. doi: 10.1016/j.eclinm.2020.100683 – volume: 34 start-page: 420 year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib23 article-title: A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment publication-title: Curr. Opin. Psychiatr. doi: 10.1097/YCO.0000000000000713 – volume: 144 start-page: 3576 year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib2 article-title: Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease publication-title: Brain doi: 10.1093/brain/awab302 – volume: 4 start-page: 563 year: 2008 ident: 10.1016/j.jpsychires.2022.03.033_bib7 article-title: Relationships between the Pittsburgh sleep quality Index (PSQI), epworth sleepiness scale (ESS), and clinical/polysomnographic measures in a community sample publication-title: J. Clin. Sleep Med. doi: 10.5664/jcsm.27351 – year: 2022 ident: 10.1016/j.jpsychires.2022.03.033_bib13 article-title: For the IC-CoDE task force publication-title: Neuropsychology – year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib25 – volume: 1 start-page: 15 year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib9 article-title: Central nervous system manifestations of COVID-19: a critical review and proposed research agenda publication-title: J. Int. Neuropsychol. Soc. – volume: 6 start-page: 353 year: 1996 ident: 10.1016/j.jpsychires.2022.03.033_bib8 article-title: Development of the 12-item cross-cultural Smell identification test (CC-sit) publication-title: Laryngoscope doi: 10.1097/00005537-199603000-00021 – volume: 27 start-page: 253 year: 2012 ident: 10.1016/j.jpsychires.2022.03.033_bib17 article-title: Spanish normative studies in a young adult population (NEURONORMA young adults Project): methods and characteristics of the sample publication-title: Neurologia doi: 10.1016/j.nrl.2011.12.019 – volume: 2 year: 2020 ident: 10.1016/j.jpsychires.2022.03.033_bib24 article-title: Frequent neurocognitive deficits after recovery from COVID-19 publication-title: Brain Commun. doi: 10.1093/braincomms/fcaa205 – volume: 284 start-page: 1 year: 2021 ident: 10.1016/j.jpsychires.2022.03.033_bib15 article-title: An investigation of working memory deficits in depression using the n-back task: a systematic review and meta-analysis publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2021.01.084 – volume: 41 start-page: 887 year: 2014 ident: 10.1016/j.jpsychires.2022.03.033_bib20 article-title: Cognitive and neuroimaging profiles in mild cognitive impairment and Alzheimer's disease: data from the Spanish Multicenter Normative Studies (NEURONORMA Project) publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-132186
SSID	ssj0007214
Score	2.6510973
Snippet	Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and...
SourceID	pubmedcentral proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	40
SubjectTerms	Cognition - physiology Cognitive Cognitive Dysfunction - etiology Cognitive Dysfunction - psychology COVID-19 COVID-19 - complications Cross-Sectional Studies Executive Function - physiology Humans Long-term COVID Neuropsychological assessment Neuropsychological Tests Post-Acute COVID-19 Syndrome
Title	Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0022395622001625 https://dx.doi.org/10.1016/j.jpsychires.2022.03.033 https://www.ncbi.nlm.nih.gov/pubmed/35349797 https://www.proquest.com/docview/2645470022 https://pubmed.ncbi.nlm.nih.gov/PMC8943429
Volume	150
WOSCitedRecordID	wos000792888700006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-1379 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007214 issn: 0022-3956 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DSFeEHc6YAoSr5lyne3xFJUhhmAgUVV5i1zb2VpFadWbxu_iD3J8idu0IAoSUhVVqe3UPp99jk_O-YzQGy6JCNhZ6QsqmJ8wPeci4vOIRqKMcFDqKN_BJ3x1RfKcfu10fjS5MKsK1zW5vaXT_ypquAfCVqmzfyFu1yjcgO8gdLiC2OG6l-B7LiBIfJ8rtWXOArdiaKLNe18Gl-_8kJrMdBVYPpM3Nphdc1xOWyvjmoV215B1AdOaDXrDO6bsY1ldMzHxswq6a7yyelWpnTYYqMNc5v43pgva9KER225AvdAnYbViM-PyzqpStegWraXxmo-ulzYHwHoyYBPsIq42MwuoIRp3q7PhpbXrq6F2spra-C53dIBxR4xPx6b70PFT9TTNZWtIN9q021vq0AUpNvFv42LdUqFaKoIYPvEBOopwSmEpPcouL_KPzgCATXXiSOqhOzaAzIQV_vpf_c4q2t31bAfvblhD_QfovpW-lxn4PUQdWT9Cdz_bQI3HKHco9DZQ6K1R6CkUeg0Kz73Ma2HQ28WgpzH4BPXfX_R7H3x7iIfP0_hs4QvBBEkDQVPK9O52mHK1r2WECRbIMMVBgjlYjYkgVAxxIsOAKzsadtY8DuOn6LCe1PI58iIYbRKUSUrBpGJJSDCWQcIJEcM4lrLsItyMYcEtwb06Z6Uq_iTJLgpdzakhedmjDm3EVDRJzKB2C0DhHnXfurrW0DUG7J61XzeoKEAXqBd8rJaTJRTS9HwKd130zKDE9SdO44RiimGUWvhxBRTPfPuXenSj-ebVEQ1gth7_wyi9QPfWM_0lOlzMlvIVusNXi9F8doIOcE5O7PT5CQYy_fc
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cognitive+dysfunction+associated+with+COVID-19%3A+A+comprehensive+neuropsychological+study&rft.jtitle=Journal+of+psychiatric+research&rft.au=Delgado-Alonso%2C+Cristina&rft.au=Valles-Salgado%2C+Maria&rft.au=Delgado-%C3%81lvarez%2C+Alfonso&rft.au=Yus%2C+Miguel&rft.date=2022-06-01&rft.issn=0022-3956&rft.volume=150&rft.spage=40&rft.epage=46&rft_id=info:doi/10.1016%2Fj.jpsychires.2022.03.033&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jpsychires_2022_03_033
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3956&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3956&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3956&client=summon