Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects

Ketamine's mechanism of action was assessed using gamma power from magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 unmedicated subjects with major depressive disorder (MDD) and 25 healthy controls enrolled in a double-blind, placebo-controlled, randomized cross-ove...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 24; no. 7; pp. 1040 - 1052
Main Authors:	Nugent, Allison C, Ballard, Elizabeth D, Gould, Todd D, Park, Lawrence T, Moaddel, Ruin, Brutsche, Nancy E, Zarate, Jr, Carlos A
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.07.2019
Subjects:	Adult Antidepressants Antidepressive Agents - pharmacology Case-Control Studies Cross-Over Studies Depression - drug therapy Depressive Disorder, Major - drug therapy Depressive Disorder, Treatment-Resistant - drug therapy Double-Blind Method Electrophysiological Phenomena - physiology Female Homeostasis Humans Ketamine Ketamine - metabolism Ketamine - pharmacology Magnetoencephalography Magnetoencephalography - methods Male Mental depression Metabolism Metabolites Middle Aged Neurobiology Pathophysiology Stress
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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