Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

Inflammation is a major contributor to the pathogenesis of ischemic acute kidney injury (AKI), which complicates the post-operative outcomes of large numbers of hospitalized surgical patients. Hydroxychloroquine (HCQ), a well-known anti-malarial drug, is commonly used in clinical practice for its an...

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Veröffentlicht in:	Cell death & disease Jg. 9; H. 3; S. 351 - 14
Hauptverfasser:	Tang, Tao-Tao, Lv, Lin-Li, Pan, Ming-Ming, Wen, Yi, Wang, Bin, Li, Zuo-Lin, Wu, Min, Wang, Feng-Mei, Crowley, Steve D, Liu, Bi-Cheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 02.03.2018 Springer Nature B.V
Schlagworte:	13/21 13/51 13/89 14 14/19 38 38/77 64/60 82/80 Acute Kidney Injury - drug therapy Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - therapeutic use Antibodies Biochemistry Biomedical and Life Sciences Cathepsin B - metabolism Cathepsin L Cathepsin L - metabolism Cell activation Cell Biology Cell Culture Cell Line Cell Survival - drug effects Creatinine Creatinine - blood Cytoplasm Disease Models, Animal Hepatitis A Virus Cellular Receptor 1 - blood Humans Hydroxychloroquine Hydroxychloroquine - metabolism Hydroxychloroquine - therapeutic use Hypoxia Immunology Inflammasomes Inflammasomes - metabolism Inflammation Ischemia Kidneys Life Sciences Lysosomes Macrophages Macrophages - drug effects Male Mice Mice, Inbred C57BL Neutrophil Infiltration - drug effects NF-kappa B - metabolism NF-κB protein NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Renal function Reperfusion Reperfusion Injury - drug therapy Rodents Surgery
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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