Prevalence and oncologic outcomes of BRCA 1/2 mutations in unselected triple-negative breast cancer patients in Korea

Purpose Triple-negative breast cancer (TNBC) accounts for 10–20% of all diagnosed BCs and it is enriched in BRCA1 mutation. Guidelines for Western countries suggest that BRCA 1 / 2 genetic testing should be done for patients with TNBC diagnosed less than 60 years, but there is lack of evidence suppo...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 173; no. 2; pp. 385 - 395
Main Authors:	Ryu, Jai Min, Choi, Hee Jun, Kim, Isaac, Nam, Seok Jin, Kim, Seok Won, Yu, Jonghan, Lee, Se Kyung, Choi, Doo Ho, Park, Yeon Hee, Kim, Jong-Won, Seo, Jeong-sun, Park, Jung-Hoon, Lee, Jeong Eon, Kim, Sung-Won
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.01.2019 Springer Springer Nature B.V
Subjects:	Adult Age Factors Analysis Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast cancer Cancer patients Cancer research Care and treatment Clinical Trial Disease-Free Survival DNA DNA Mutational Analysis DNA sequencing Female Follow-Up Studies Gene mutation Genetic aspects Genetic screening Genetic testing Genetic Testing - methods Genetic Testing - statistics & numerical data Health risk assessment High-Throughput Nucleotide Sequencing Humans Kaplan-Meier Estimate Medical centers Medical schools Medicine Medicine & Public Health Middle Aged Mutation Oncology Patient outcomes Population genetics Republic of Korea - epidemiology Retrospective Studies Surgery Survival Triple Negative Breast Neoplasms - diagnosis Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - mortality Republic of Korea Mutation Triple-negative Breast Neoplasms Breast neoplasm / BRCA 1/2
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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