Reprogramming of fatty acid metabolism in cancer

A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty acid metabolism in cancer has received renewed interest as, aside their princ...

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Vydané v:British journal of cancer Ročník 122; číslo 1; s. 4 - 22
Hlavní autori: Koundouros, Nikos, Poulogiannis, George
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.01.2020
Nature Publishing Group
Predmet:
1-Phosphatidylinositol 3-kinase
631/67/2327
631/80/86/2365
AKT protein
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Carcinogenesis - drug effects
Carcinogenesis - metabolism
Cell survival
Drug Resistance
Epidemiology
Epigenome
Fatty acids
Fatty Acids - metabolism
Humans
Lipogenesis - drug effects
Macromolecules
Metabolism
Metastases
Molecular Medicine
Neoplasms - drug therapy
Neoplasms - metabolism
Oncology
Oxidation
Phosphatidylinositol 3-Kinases - metabolism
Phosphoinositide-3 Kinase Inhibitors - therapeutic use
Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Proto-Oncogene Proteins c-akt - metabolism
Review
Review Article
Signal transduction
Signal Transduction - drug effects
TOR protein
TOR Serine-Threonine Kinases - antagonists & inhibitors
TOR Serine-Threonine Kinases - metabolism
Tumor microenvironment
Tumor Microenvironment - drug effects
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
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Popis
Shrnutí:A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty acid metabolism in cancer has received renewed interest as, aside their principal role as structural components of the membrane matrix, they are important secondary messengers, and can also serve as fuel sources for energy production. In this review, we will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research. (1) The role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids. (2) The mechanisms through which molecular heterogeneity and oncogenic signal transduction pathways, such as PI3K–AKT–mTOR signalling, regulate fatty acid metabolism. (3) The role of fatty acids as essential mediators of cancer progression and metastasis, through remodelling of the tumour microenvironment. (4) Therapeutic strategies and considerations for successfully targeting fatty acid metabolism in cancer. Further research focusing on the complex interplay between oncogenic signalling and dysregulated fatty acid metabolism holds great promise to uncover novel metabolic vulnerabilities and improve the efficacy of targeted therapies.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ObjectType-Review-3
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ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-019-0650-z