FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

Accumulating studies suggest that overnutrition-associated obesity may lead to development of type 2 diabetes mellitus and metabolic syndromes (MetS). MetS and its components are important risk factors of mild cognitive impairment, age-related cognitive decline, vascular dementia, and Alzheimer’s di...

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Bibliographic Details
Published in:	Molecular neurobiology Vol. 55; no. 6; pp. 4702 - 4717
Main Authors:	Wang, Qingzhi, Yuan, Jing, Yu, Zhanyang, Lin, Li, Jiang, Yinghua, Cao, Zeyuan, Zhuang, Pengwei, Whalen, Michael J., Song, Bo, Wang, Xiao-Jie, Li, Xiaokun, Lo, Eng H., Xu, Yuming, Wang, Xiaoying
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.06.2018 Springer Nature B.V
Subjects:	Age Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anxiety Anxiety - complications Anxiety - drug therapy Behavior, Animal Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Cell Biology Clinical significance Cognitive ability Cognitive Dysfunction - complications Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Cognitive Dysfunction - pathology Cytokines - metabolism Dementia disorders Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet, High-Fat Fibroblast growth factors Fibroblast Growth Factors - pharmacology Fibroblast Growth Factors - therapeutic use Glucose - metabolism Glucose tolerance High fat diet Hippocampus Hippocampus - metabolism Humans Hyperlipidemia Hyperlipidemias - complications Hyperlipidemias - drug therapy Inflammation Inflammation - complications Inflammation - drug therapy Insulin Insulin Resistance Male Metabolic disorders Metabolism Mice, Inbred C57BL Mice, Obese Microglia - drug effects Microglia - metabolism Microglia - pathology Neurobiology Neurogenesis Neurogenesis - drug effects Neurology Neuronal Plasticity - drug effects Neurosciences Obesity Overnutrition Receptors, Fibroblast Growth Factor - metabolism Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Risk factors Rodents Signal Transduction Vascular dementia Fibroblast growth factor 21 Inflammation Obese mice High-fat diet Metabolic disorders Cognitive impairment
ISSN:	0893-7648, 1559-1182, 1559-1182
Online Access:	Get full text
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