Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons

Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while r...

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Vydané v:	Nature neuroscience Ročník 21; číslo 2; s. 258 - 269
Hlavní autori:	Sasaki, Takuya, Piatti, Verónica C, Hwaun, Ernie, Ahmadi, Siavash, Lisman, John E, Leutgeb, Stefan, Leutgeb, Jill K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Nature Publishing Group 01.02.2018
Predmet:	Action Potentials - physiology Activity patterns Animal memory Animals CA3 Region, Hippocampal - cytology Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - injuries Dentate Gyrus - physiology Granule cells Hippocampus Male Maze Learning - physiology Memory tasks Memory, Short-Term - physiology Mental task performance Nerve Net - physiology Neurons Neurons - physiology Rats Rats, Long-Evans Reinforcement Reward Rodents Short term memory Spatial memory Spatial Memory - physiology Statistics, Nonparametric Task complexity Time Factors
ISSN:	1097-6256, 1546-1726, 1546-1726
On-line prístup:	Získať plný text
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