Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons

Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while r...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 21; no. 2; pp. 258 - 269
Main Authors:	Sasaki, Takuya, Piatti, Verónica C, Hwaun, Ernie, Ahmadi, Siavash, Lisman, John E, Leutgeb, Stefan, Leutgeb, Jill K
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.02.2018
Subjects:	Action Potentials - physiology Activity patterns Animal memory Animals CA3 Region, Hippocampal - cytology Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - injuries Dentate Gyrus - physiology Granule cells Hippocampus Male Maze Learning - physiology Memory tasks Memory, Short-Term - physiology Mental task performance Nerve Net - physiology Neurons Neurons - physiology Rats Rats, Long-Evans Reinforcement Reward Rodents Short term memory Spatial memory Spatial Memory - physiology Statistics, Nonparametric Task complexity Time Factors
ISSN:	1097-6256, 1546-1726, 1546-1726
Online Access:	Get full text
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