Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study review...

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Published in:	BMC infectious diseases Vol. 17; no. 1; pp. 302 - 12
Main Authors:	Pontrelli, Giuseppe, De Crescenzo, Franco, Buzzetti, Roberto, Jenkner, Alessandro, Balduzzi, Sara, Calò Carducci, Francesca, Amodio, Donato, De Luca, Maia, Chiurchiù, Sara, Davies, Elin Haf, Copponi, Giorgia, Simonetti, Alessandra, Ferretti, Elena, Di Franco, Valeria, Rasi, Virginia, Della Corte, Martina, Gramatica, Luca, Ciabattini, Marco, Livadiotti, Susanna, Rossi, Paolo
Format:	Journal Article
Language:	English
Published:	London BioMed Central 24.04.2017 Springer Nature B.V BMC
Subjects:	Accuracy Adults Age Bacterial and fungal diseases Bacterial infections Biomarkers Biomarkers - blood Bivariate analysis Calcitonin - blood Child Child, Preschool Children Confidence intervals Cytokines Data processing Diagnosis Diagnostic systems Heart rate Heterogeneity Humans Infant Infant, Newborn Infections Infectious Diseases Inflammation Internal Medicine Libraries Mathematical analysis Medical Microbiology Medicine Medicine & Public Health Meta-analysis Neonates Parasitology Patients Pediatrics Procalcitonin Prospective Studies Proteins Reproducibility of Results Research Article Sensitivity analysis Sensitivity and Specificity Sepsis Sepsis - diagnosis Sepsis - microbiology Standard deviation Studies Systemic inflammatory response syndrome Tropical Medicine Systemic inflammatory response syndrome Procalcitonin Sepsis Infant Biological markers Child Meta-analysis
ISSN:	1471-2334, 1471-2334
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Abstract	Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. Methods A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as “probable” by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated. Results We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies. Conclusions PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity. Trial registration PROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016.
AbstractList	A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis.BACKGROUNDA number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis.A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as "probable" by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated.METHODSA comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as "probable" by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated.We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies.RESULTSWe included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies.PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity.CONCLUSIONSPCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity.PROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016.TRIAL REGISTRATIONPROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016. Abstract Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. Methods A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as “probable” by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated. Results We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies. Conclusions PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity. Trial registration PROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016. A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as "probable" by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated. We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies. PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity. PROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016. Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. Methods A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as “probable” by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated. Results We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies. Conclusions PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity. Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. Methods A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis. Studies in which the presence of infection had been confirmed microbiologically or classified as “probable” by chart review were included. Studies comparing patients to healthy subjects were excluded. We analysed data on neonates and children separately. Our primary outcome was the diagnostic accuracy of PCT at the cut-off of 2-2.5 ng/ml, while as secondary outcomes we analysed PCT cut-offs <2 ng/ml and >2.5 ng/ml. Pooled sensitivities and specificities were calculated by a bivariate meta-analysis and heterogeneity was graphically evaluated. Results We included 17 studies, with a total of 1408 patients (1086 neonates and 322 children). Studies on neonates with early onset sepsis (EOS) and late onset sepsis (LOS) were grouped together. In the neonatal group, we calculated a sensitivity of 0.85, confidence interval (CI) (0.76; 0.90) and specificity of 0.54, CI (0.38; 0.70) at the PCT cut-off of 2.0-2.5 ng/ml. In the paediatric group it was not possible to undertake a pooled analysis at the PCT cut-off of 2.0-2.5 ng/ml, due to the paucity of the studies. Conclusions PCT shows a moderate accuracy for the diagnosis of sepsis in neonates with suspected sepsis at the cut-off of 2.0-2.5 ng/ml. More studies with high methodological quality are warranted, particularly in neonates, studies considering EOS and LOS separately are needed to improve specificity. Trial registration PROSPERO Identifier: CRD42016033809 . Registered 30 Jan 2016.
ArticleNumber	302
Author	Della Corte, Martina Jenkner, Alessandro Amodio, Donato Di Franco, Valeria Ferretti, Elena Rossi, Paolo Gramatica, Luca Buzzetti, Roberto Chiurchiù, Sara Pontrelli, Giuseppe Rasi, Virginia Calò Carducci, Francesca Balduzzi, Sara Livadiotti, Susanna De Luca, Maia Davies, Elin Haf Simonetti, Alessandra De Crescenzo, Franco Copponi, Giorgia Ciabattini, Marco
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Cites_doi	10.3329/bmrcb.v37i2.8432 10.1136/adc.2005.085449 10.1186/cc13908 10.1097/01.CCM.0000050454.01978.3B 10.1016/S1473-3099(04)01146-6 10.1097/01.CCM.0000226413.54364.36 10.1016/bs.acc.2014.11.005 10.1128/CMR.00016-12 10.1186/s13052-016-0242-y 10.1136/bmj.h3017 10.1136/adc.2005.077446 10.1016/S1413-8670(10)70052-0 10.1038/sj.jp.7211296 10.1016/S1473-3099(07)70052-X 10.1007/s00134-011-2174-8 10.1016/S0022-3476(96)70374-8 10.1097/SHK.0000000000000753 10.1016/j.jclinepi.2005.02.022 10.1258/0004563021901874 10.1097/01.PCC.0000149131.72248.E6 10.1186/cc13183 10.1186/cc13157 10.1001/jama.1997.03550030074038 10.1016/0140-6736(93)90277-N 10.1007/s00134-009-1637-7 10.1097/INF.0000000000000030 10.1016/S1473-3099(12)70323-7 10.7326/0003-4819-155-8-201110180-00009 10.1007/s10096-003-0941-3 10.1097/PCC.0b013e31817285a6 10.1097/00003246-199206000-00025 10.3923/pjbs.2008.1785.1790 10.1111/j.1651-2227.2003.tb00534.x 10.1111/j.1440-1754.2007.01230.x 10.1186/1471-2431-6-16 10.1111/j.1469-0691.2004.01044.x 10.1373/clinchem.2004.032144 10.1016/B978-0-12-405211-6.00007-3 10.1053/jcrc.2003.YJCRC11 10.1086/514576 10.1128/CMR.00031-13 10.1001/jama.2016.0287 10.1007/s00134-012-2798-3
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References	S Masson (2396_CR21) 2014; 18 R Arkader (2396_CR52) 2006; 91 Y He (2396_CR53) 2017; 47 P Rossi (2396_CR30) 2010 WM Fendler (2396_CR13) 2008; 44 C Chiesa (2396_CR14) 1998; 26 DJ Gattas (2396_CR25) 2003; 18 L Simon (2396_CR50) 2008; 9 B Goldstein (2396_CR5) 2005; 6 P Povoa (2396_CR9) 2005; 11 BM Tang (2396_CR18) 2007; 7 NY Boo (2396_CR39) 2008; 49 KE Sands (2396_CR8) 1997; 278 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference (2396_CR1) 1992; 20 B Uzzan (2396_CR23) 2006; 34 KA Simonsen (2396_CR26) 2014; 27 R Vazzalwar (2396_CR47) 2005; 25 2396_CR12 A Plunkett (2396_CR6) 2015; 350 SD Carrigan (2396_CR7) 2004; 50 B Pourakbari (2396_CR51) 2010; 14 K Reinhart (2396_CR4) 2012; 25 M Singer (2396_CR3) 2016; 315 C Wacker (2396_CR17) 2013; 13 MM Koskenvuo (2396_CR41) 2003; 22 S Kibe (2396_CR24) 2011; 66 T Rowland (2396_CR11) 2015; 68 J Garnacho-Montero (2396_CR20) 2014; 18 BS Naher (2396_CR43) 2011; 37 MM Levy (2396_CR2) 2003; 31 A Prkno (2396_CR22) 2013; 17 K Sakha (2396_CR45) 2008; 11 M Assicot (2396_CR19) 1993; 341 StataCorp (2396_CR34) 2013 J Guibourdenche (2396_CR40) 2002; 39 FI Calo Carducci (2396_CR49) 2014; 33 JB Reitsma (2396_CR31) 2005; 58 AM Rossum van (2396_CR16) 2004; 4 EK Vouloumanou (2396_CR27) 2011; 37 Y Zahedpasha (2396_CR48) 2009; 19 L Pacifico (2396_CR10) 2013; 59 L Bender (2396_CR37) 2008; 55 M Groselj-Grenc (2396_CR35) 2009; 35 D Turner (2396_CR29) 2006; 91 2396_CR33 D Gendrel (2396_CR15) 1996; 128 PF Whiting (2396_CR28) 2011; 155 2396_CR32 LJ Schlapbach (2396_CR46) 2013; 39 M Adib (2396_CR36) 2012; 15 JB Lopez Sastre (2396_CR42) 2006; 6 B Resch (2396_CR44) 2003; 92 B Bonac (2396_CR38) 2000; 440 15830005 - J Perinatol. 2005 Jun;25(6):397-402 17317602 - Lancet Infect Dis. 2007 Mar;7(3):210-7 16326799 - Arch Dis Child. 2006 Feb;91(2):117-20 9524841 - Clin Infect Dis. 1998 Mar;26(3):664-72 18496408 - Pediatr Crit Care Med. 2008 Jul;9(4):407-13 15166107 - Clin Chem. 2004 Aug;50(8):1301-14 24396135 - Clin Microbiol Rev. 2014 Jan;27(1):21-47 25858869 - Adv Clin Chem. 2015 ;68:71-86 24393424 - Crit Care. 2014 Jan 07;18(1):R6 15451490 - Lancet Infect Dis. 2004 Oct;4(10 ):620-30 26060188 - BMJ. 2015 Jun 09;350:h3017 19756501 - Intensive Care Med. 2009 Nov;35(11):1950-8 22007046 - Ann Intern Med. 2011 Oct 18;155(8):529-36 23375419 - Lancet Infect Dis. 2013 May;13(5):426-35 21380522 - Intensive Care Med. 2011 May;37(5):747-62 21877603 - Bangladesh Med Res Counc Bull. 2011 Aug;37(2):40-6 11928760 - Ann Clin Biochem. 2002 Mar;39(Pt 2):130-5 8094770 - Lancet. 1993 Feb 27;341(8844):515-8 16547079 - Arch Dis Child Fetal Neonatal Ed. 2006 Jul;91(4):F283-6 12640615 - J Crit Care. 2003 Mar;18(1):52-8 15636651 - Pediatr Crit Care Med. 2005 Jan;6(1):2-8 23296629 - Intensive Care Med. 2013 Apr;39(4):754-63 18817217 - Pak J Biol Sci. 2008 Jul 15;11(14 ):1785-90 11005618 - Pflugers Arch. 2000;440(5 Suppl):R72-4 23461137 - Adv Clin Chem. 2013;59:203-63 12750960 - Eur J Clin Microbiol Infect Dis. 2003 Jun;22(6):377-8 21398306 - J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii33-40 26903338 - JAMA. 2016 Feb 23;315(8):801-10 9218672 - JAMA. 1997 Jul 16;278(3):234-40 27648693 - Shock. 2017 Feb;47(2):140-147 16709255 - BMC Pediatr. 2006 May 18;6:16 23493845 - Iran J Basic Med Sci. 2012 Mar;15(2):777-82 23989103 - Pediatr Infect Dis J. 2014 Feb;33(2):199-203 15679483 - Clin Microbiol Infect. 2005 Feb;11(2):101-8 24330744 - Crit Care. 2013 Dec 11;17 (6):R291 23034322 - Clin Microbiol Rev. 2012 Oct;25(4):609-34 12710654 - Acta Paediatr. 2003;92 (2):243-5 18363001 - Singapore Med J. 2008 Mar;49(3):204-8 1597042 - Crit Care Med. 1992 Jun;20(6):864-74 19232162 - Dan Med Bull. 2008 Nov;55(4):219-23 27116911 - Ital J Pediatr. 2016 Apr 27;42:44 12682500 - Crit Care Med. 2003 Apr;31(4):1250-6 20835508 - Braz J Infect Dis. 2010 May-Jun;14 (3):252-5 24903083 - Crit Care. 2014 Jun 05;18(3):R116 17927729 - J Paediatr Child Health. 2008 Mar;44(3):114-8 8618197 - J Pediatr. 1996 Apr;128(4):570-3 16168343 - J Clin Epidemiol. 2005 Oct;58(10):982-90 16715031 - Crit Care Med. 2006 Jul;34(7):1996-2003
References_xml	– volume: 37 start-page: 40 issue: 2 year: 2011 ident: 2396_CR43 publication-title: Bangladesh Med Res Counc Bull doi: 10.3329/bmrcb.v37i2.8432 – volume: 91 start-page: F283 issue: 4 year: 2006 ident: 2396_CR29 publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/adc.2005.085449 – volume: 49 start-page: 204 issue: 3 year: 2008 ident: 2396_CR39 publication-title: Singap Med J – volume: 18 start-page: R116 issue: 3 year: 2014 ident: 2396_CR20 publication-title: Crit Care doi: 10.1186/cc13908 – volume: 31 start-page: 1250 issue: 4 year: 2003 ident: 2396_CR2 publication-title: Crit Care Med doi: 10.1097/01.CCM.0000050454.01978.3B – volume: 4 start-page: 620 issue: 10 year: 2004 ident: 2396_CR16 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(04)01146-6 – volume: 34 start-page: 1996 issue: 7 year: 2006 ident: 2396_CR23 publication-title: Crit Care Med doi: 10.1097/01.CCM.0000226413.54364.36 – volume: 68 start-page: 71 year: 2015 ident: 2396_CR11 publication-title: Adv Clin Chem doi: 10.1016/bs.acc.2014.11.005 – volume: 25 start-page: 609 issue: 4 year: 2012 ident: 2396_CR4 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00016-12 – ident: 2396_CR12 doi: 10.1186/s13052-016-0242-y – volume: 350 start-page: h3017 year: 2015 ident: 2396_CR6 publication-title: BMJ doi: 10.1136/bmj.h3017 – volume: 66 start-page: ii33 issue: Suppl 2 year: 2011 ident: 2396_CR24 publication-title: J Antimicrob Chemother – ident: 2396_CR32 – volume: 91 start-page: 117 issue: 2 year: 2006 ident: 2396_CR52 publication-title: Arch Dis Child doi: 10.1136/adc.2005.077446 – volume: 14 start-page: 252 issue: 3 year: 2010 ident: 2396_CR51 publication-title: Braz J Infect Dis doi: 10.1016/S1413-8670(10)70052-0 – volume: 25 start-page: 397 issue: 6 year: 2005 ident: 2396_CR47 publication-title: J Perinatol doi: 10.1038/sj.jp.7211296 – volume: 7 start-page: 210 issue: 3 year: 2007 ident: 2396_CR18 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(07)70052-X – volume: 37 start-page: 747 issue: 5 year: 2011 ident: 2396_CR27 publication-title: Intensive Care Med doi: 10.1007/s00134-011-2174-8 – volume: 128 start-page: 570 issue: 4 year: 1996 ident: 2396_CR15 publication-title: J Pediatr doi: 10.1016/S0022-3476(96)70374-8 – volume-title: Report on the expert meeting on neonatal and Paediatric sepsis year: 2010 ident: 2396_CR30 – volume: 47 start-page: 140 issue: 2 year: 2017 ident: 2396_CR53 publication-title: Shock doi: 10.1097/SHK.0000000000000753 – volume: 58 start-page: 982 issue: 10 year: 2005 ident: 2396_CR31 publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2005.02.022 – volume: 39 start-page: 130 issue: Pt 2 year: 2002 ident: 2396_CR40 publication-title: Ann Clin Biochem doi: 10.1258/0004563021901874 – volume: 6 start-page: 2 issue: 1 year: 2005 ident: 2396_CR5 publication-title: Pediatr Crit Care Med doi: 10.1097/01.PCC.0000149131.72248.E6 – volume: 18 start-page: R6 issue: 1 year: 2014 ident: 2396_CR21 publication-title: Crit Care doi: 10.1186/cc13183 – volume: 17 start-page: R291 issue: 6 year: 2013 ident: 2396_CR22 publication-title: Crit Care doi: 10.1186/cc13157 – volume: 278 start-page: 234 issue: 3 year: 1997 ident: 2396_CR8 publication-title: JAMA doi: 10.1001/jama.1997.03550030074038 – volume: 341 start-page: 515 issue: 8844 year: 1993 ident: 2396_CR19 publication-title: Lancet doi: 10.1016/0140-6736(93)90277-N – volume: 35 start-page: 1950 issue: 11 year: 2009 ident: 2396_CR35 publication-title: Intensive Care Med doi: 10.1007/s00134-009-1637-7 – volume: 33 start-page: 199 issue: 2 year: 2014 ident: 2396_CR49 publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0000000000000030 – volume: 15 start-page: 777 issue: 2 year: 2012 ident: 2396_CR36 publication-title: Iran J Basic Med Sci – volume: 13 start-page: 426 issue: 5 year: 2013 ident: 2396_CR17 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(12)70323-7 – volume: 155 start-page: 529 issue: 8 year: 2011 ident: 2396_CR28 publication-title: Ann Intern Med doi: 10.7326/0003-4819-155-8-201110180-00009 – ident: 2396_CR33 – volume: 22 start-page: 377 issue: 6 year: 2003 ident: 2396_CR41 publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-003-0941-3 – volume: 9 start-page: 407 issue: 4 year: 2008 ident: 2396_CR50 publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0b013e31817285a6 – volume: 20 start-page: 864 issue: 6 year: 1992 ident: 2396_CR1 publication-title: Crit Care Med doi: 10.1097/00003246-199206000-00025 – volume: 11 start-page: 1785 issue: 14 year: 2008 ident: 2396_CR45 publication-title: Pak J Biol Sci doi: 10.3923/pjbs.2008.1785.1790 – volume-title: Stata statistical software: release 13 year: 2013 ident: 2396_CR34 – volume: 55 start-page: 219 issue: 4 year: 2008 ident: 2396_CR37 publication-title: Dan Med Bull – volume: 92 start-page: 243 issue: 2 year: 2003 ident: 2396_CR44 publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.2003.tb00534.x – volume: 44 start-page: 114 issue: 3 year: 2008 ident: 2396_CR13 publication-title: J Paediatr Child Health doi: 10.1111/j.1440-1754.2007.01230.x – volume: 6 start-page: 16 year: 2006 ident: 2396_CR42 publication-title: BMC Pediatr doi: 10.1186/1471-2431-6-16 – volume: 19 start-page: 117 issue: 2 year: 2009 ident: 2396_CR48 publication-title: Iran J Paediatric – volume: 11 start-page: 101 issue: 2 year: 2005 ident: 2396_CR9 publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2004.01044.x – volume: 50 start-page: 1301 issue: 8 year: 2004 ident: 2396_CR7 publication-title: Clin Chem doi: 10.1373/clinchem.2004.032144 – volume: 59 start-page: 203 year: 2013 ident: 2396_CR10 publication-title: Adv Clin Chem doi: 10.1016/B978-0-12-405211-6.00007-3 – volume: 18 start-page: 52 issue: 1 year: 2003 ident: 2396_CR25 publication-title: J Crit Care doi: 10.1053/jcrc.2003.YJCRC11 – volume: 26 start-page: 664 issue: 3 year: 1998 ident: 2396_CR14 publication-title: Clin Infect Dis doi: 10.1086/514576 – volume: 27 start-page: 21 issue: 1 year: 2014 ident: 2396_CR26 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00031-13 – volume: 440 start-page: R72 issue: 5 Suppl year: 2000 ident: 2396_CR38 publication-title: Pflugers Arch – volume: 315 start-page: 801 issue: 8 year: 2016 ident: 2396_CR3 publication-title: JAMA doi: 10.1001/jama.2016.0287 – volume: 39 start-page: 754 issue: 4 year: 2013 ident: 2396_CR46 publication-title: Intensive Care Med doi: 10.1007/s00134-012-2798-3 – reference: 9524841 - Clin Infect Dis. 1998 Mar;26(3):664-72 – reference: 8618197 - J Pediatr. 1996 Apr;128(4):570-3 – reference: 23034322 - Clin Microbiol Rev. 2012 Oct;25(4):609-34 – reference: 12710654 - Acta Paediatr. 2003;92 (2):243-5 – reference: 9218672 - JAMA. 1997 Jul 16;278(3):234-40 – reference: 21877603 - Bangladesh Med Res Counc Bull. 2011 Aug;37(2):40-6 – reference: 12682500 - Crit Care Med. 2003 Apr;31(4):1250-6 – reference: 23461137 - Adv Clin Chem. 2013;59:203-63 – reference: 16709255 - BMC Pediatr. 2006 May 18;6:16 – reference: 27116911 - Ital J Pediatr. 2016 Apr 27;42:44 – reference: 24396135 - Clin Microbiol Rev. 2014 Jan;27(1):21-47 – reference: 25858869 - Adv Clin Chem. 2015 ;68:71-86 – reference: 26903338 - JAMA. 2016 Feb 23;315(8):801-10 – reference: 17927729 - J Paediatr Child Health. 2008 Mar;44(3):114-8 – reference: 18363001 - Singapore Med J. 2008 Mar;49(3):204-8 – reference: 21380522 - Intensive Care Med. 2011 May;37(5):747-62 – reference: 19756501 - Intensive Care Med. 2009 Nov;35(11):1950-8 – reference: 26060188 - BMJ. 2015 Jun 09;350:h3017 – reference: 18496408 - Pediatr Crit Care Med. 2008 Jul;9(4):407-13 – reference: 23375419 - Lancet Infect Dis. 2013 May;13(5):426-35 – reference: 27648693 - Shock. 2017 Feb;47(2):140-147 – reference: 22007046 - Ann Intern Med. 2011 Oct 18;155(8):529-36 – reference: 12640615 - J Crit Care. 2003 Mar;18(1):52-8 – reference: 15636651 - Pediatr Crit Care Med. 2005 Jan;6(1):2-8 – reference: 12750960 - Eur J Clin Microbiol Infect Dis. 2003 Jun;22(6):377-8 – reference: 11005618 - Pflugers Arch. 2000;440(5 Suppl):R72-4 – reference: 24903083 - Crit Care. 2014 Jun 05;18(3):R116 – reference: 15830005 - J Perinatol. 2005 Jun;25(6):397-402 – reference: 15679483 - Clin Microbiol Infect. 2005 Feb;11(2):101-8 – reference: 20835508 - Braz J Infect Dis. 2010 May-Jun;14 (3):252-5 – reference: 21398306 - J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii33-40 – reference: 16168343 - J Clin Epidemiol. 2005 Oct;58(10):982-90 – reference: 19232162 - Dan Med Bull. 2008 Nov;55(4):219-23 – reference: 23989103 - Pediatr Infect Dis J. 2014 Feb;33(2):199-203 – reference: 8094770 - Lancet. 1993 Feb 27;341(8844):515-8 – reference: 11928760 - Ann Clin Biochem. 2002 Mar;39(Pt 2):130-5 – reference: 15166107 - Clin Chem. 2004 Aug;50(8):1301-14 – reference: 23296629 - Intensive Care Med. 2013 Apr;39(4):754-63 – reference: 17317602 - Lancet Infect Dis. 2007 Mar;7(3):210-7 – reference: 1597042 - Crit Care Med. 1992 Jun;20(6):864-74 – reference: 16547079 - Arch Dis Child Fetal Neonatal Ed. 2006 Jul;91(4):F283-6 – reference: 24393424 - Crit Care. 2014 Jan 07;18(1):R6 – reference: 23493845 - Iran J Basic Med Sci. 2012 Mar;15(2):777-82 – reference: 16326799 - Arch Dis Child. 2006 Feb;91(2):117-20 – reference: 16715031 - Crit Care Med. 2006 Jul;34(7):1996-2003 – reference: 15451490 - Lancet Infect Dis. 2004 Oct;4(10 ):620-30 – reference: 18817217 - Pak J Biol Sci. 2008 Jul 15;11(14 ):1785-90 – reference: 24330744 - Crit Care. 2013 Dec 11;17 (6):R291
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Snippet	Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT)... A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was... Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT)... Abstract Background A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified....
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SubjectTerms	Accuracy Adults Age Bacterial and fungal diseases Bacterial infections Biomarkers Biomarkers - blood Bivariate analysis Calcitonin - blood Child Child, Preschool Children Confidence intervals Cytokines Data processing Diagnosis Diagnostic systems Heart rate Heterogeneity Humans Infant Infant, Newborn Infections Infectious Diseases Inflammation Internal Medicine Libraries Mathematical analysis Medical Microbiology Medicine Medicine & Public Health Meta-analysis Neonates Parasitology Patients Pediatrics Procalcitonin Prospective Studies Proteins Reproducibility of Results Research Article Sensitivity analysis Sensitivity and Specificity Sepsis Sepsis - diagnosis Sepsis - microbiology Standard deviation Studies Systemic inflammatory response syndrome Tropical Medicine
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Title	Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis
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