Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells

Blood-brain barrier (BBB) integrity is one of the important elements of central nervous system (CNS) homeostasis. MicroRNAs (miRs) have been demonstrated to play a role in many CNS disorders such as stroke and traumatic brain injury. MiR-212/132 are highly expressed in the CNS but their role at the...

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Veröffentlicht in:	Translational stroke research Jg. 10; H. 6; S. 672 - 683
Hauptverfasser:	Burek, Malgorzata, König, Anna, Lang, Mareike, Fiedler, Jan, Oerter, Sabrina, Roewer, Norbert, Bohnert, Michael, Thal, Serge C., Blecharz-Lang, Kinga G., Woitzik, Johannes, Thum, Thomas, Förster, Carola Y.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.12.2019 Springer Nature B.V
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - metabolism Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - pathology Cardiology Cells, Cultured Endothelial Cells - metabolism Ethics Humans Hypoxia - metabolism Hypoxia - pathology Invoices Mice MicroRNAs MicroRNAs - metabolism Neurology Neurosciences Neurosurgery Original Original Article Stroke - metabolism Stroke - pathology Tight Junction Proteins - metabolism Tight Junctions - metabolism Traumatic brain injury Vascular Surgery Zonula Occludens-1 Protein - metabolism Stroke Traumatic brain injury Blood-brain barrier Tight junctions MicroRNA-212/132 Oxygen-glucose deprivation
ISSN:	1868-4483, 1868-601X, 1868-601X
Online-Zugang:	Volltext
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