Signaling networks in immunometabolism

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells....

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Bibliographic Details
Published in:Cell research Vol. 30; no. 4; pp. 328 - 342
Main Authors: Saravia, Jordy, Raynor, Jana L., Chapman, Nicole M., Lim, Seon Ah, Chi, Hongbo
Format: Journal Article
Language:English
Published: Singapore Springer Singapore 01.04.2020
Nature Publishing Group
Subjects:
1-Phosphatidylinositol 3-kinase
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96
96/31
Adaptive immunity
AMP-Activated Protein Kinase Kinases
AMP-Activated Protein Kinases - immunology
Animals
Biomedical and Life Sciences
Cell Biology
Cytokines
Effectors
Functional programming
Humans
Immunology
Kinases
Life Sciences
LKB1 protein
Lymphocytes
Lymphocytes T
Metabolism
Networks
Phosphatidylinositol 3-Kinases - immunology
Protein Serine-Threonine Kinases - immunology
Protein-serine/threonine kinase
Regulators
Review
Review Article
Signal Transduction
Signaling
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Therapeutic applications
TOR protein
TOR Serine-Threonine Kinases - immunology
ISSN:1001-0602, 1748-7838, 1748-7838
Online Access:Get full text
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Summary:Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells. In addition, cellular metabolism promotes T cell responses and is dynamically regulated through the interplay of serine/threonine kinases, immunological cues and nutrient signaling networks. In this review, we summarize the upstream regulators and signaling effectors of key serine/threonine kinase-mediated signaling networks, including PI3K–AGC kinases, mTOR and LKB1–AMPK pathways that regulate metabolism, especially in T cells. We also provide our perspectives about the pending questions and clinical applicability of immunometabolic signaling. Understanding the regulators and effectors of immunometabolic signaling networks may uncover therapeutic targets to modulate metabolic programming and T cell responses in human disease.
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ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/s41422-020-0301-1