The role of pyroptosis in cancer: pro-cancer or pro-“host”?

Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune...

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Vydáno v:	Cell death & disease Ročník 10; číslo 9; s. 650 - 13
Hlavní autoři:	Xia, Xiaojing, Wang, Xin, Cheng, Zhe, Qin, Wanhai, Lei, Liancheng, Jiang, Jinqing, Hu, Jianhe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 09.09.2019 Springer Nature B.V
Témata:	13/95 38/77 631/67 692/699/67 Animals Antibodies Apoptosis Apoptosis - genetics Apoptosis - physiology Autophagy Biochemistry Biomedical and Life Sciences Cancer Cancer therapies Cell Biology Cell Culture Cell death Drug resistance Hearing loss Hearing Loss, Sensorineural - genetics Hearing Loss, Sensorineural - metabolism Humans Immune response Immunology Immunosuppressive agents Inflammation Life Sciences mRNA Phagocytosis Pyroptosis Pyroptosis - genetics Pyroptosis - physiology Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Review Review Article RNA, Messenger - metabolism Tumor cells Tumors
ISSN:	2041-4889, 2041-4889
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune responses. The relationship between pyroptosis and cancer is complex, and the effects of pyroptosis on cancer vary in different tissues and genetic backgrounds. On one hand, pyroptosis can inhibit the occurrence and development of tumors; on the other hand, as a type of proinflammatory death, pyroptosis can form a suitable microenvironment for tumor cell growth and thus promote tumor growth. In addition, the induction of tumor pyroptosis is also considered a potential cancer treatment strategy. Studies have shown that DFNA5 (nonsyndromic hearing impairment protein 5)/GSDME (Gasdermin-E) mRNA methylation results in lower expression levels of DFNA5/GSDME in most tumor cells than in normal cells, making it difficult to activate the pyroptosis in most tumor cells. During the treatment of malignant tumors, appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherapeutic drugs and reducing drug resistance. Therefore, induced pyroptosis may play a predominant role in the treatment of cancer. Here, we review the latest research on the anti- and protumor effects of pyroptosis and its potential applications in cancer treatment.
AbstractList	Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune responses. The relationship between pyroptosis and cancer is complex, and the effects of pyroptosis on cancer vary in different tissues and genetic backgrounds. On one hand, pyroptosis can inhibit the occurrence and development of tumors; on the other hand, as a type of proinflammatory death, pyroptosis can form a suitable microenvironment for tumor cell growth and thus promote tumor growth. In addition, the induction of tumor pyroptosis is also considered a potential cancer treatment strategy. Studies have shown that DFNA5 (nonsyndromic hearing impairment protein 5)/GSDME (Gasdermin-E) mRNA methylation results in lower expression levels of DFNA5/GSDME in most tumor cells than in normal cells, making it difficult to activate the pyroptosis in most tumor cells. During the treatment of malignant tumors, appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherapeutic drugs and reducing drug resistance. Therefore, induced pyroptosis may play a predominant role in the treatment of cancer. Here, we review the latest research on the anti- and protumor effects of pyroptosis and its potential applications in cancer treatment.Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune responses. The relationship between pyroptosis and cancer is complex, and the effects of pyroptosis on cancer vary in different tissues and genetic backgrounds. On one hand, pyroptosis can inhibit the occurrence and development of tumors; on the other hand, as a type of proinflammatory death, pyroptosis can form a suitable microenvironment for tumor cell growth and thus promote tumor growth. In addition, the induction of tumor pyroptosis is also considered a potential cancer treatment strategy. Studies have shown that DFNA5 (nonsyndromic hearing impairment protein 5)/GSDME (Gasdermin-E) mRNA methylation results in lower expression levels of DFNA5/GSDME in most tumor cells than in normal cells, making it difficult to activate the pyroptosis in most tumor cells. During the treatment of malignant tumors, appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherapeutic drugs and reducing drug resistance. Therefore, induced pyroptosis may play a predominant role in the treatment of cancer. Here, we review the latest research on the anti- and protumor effects of pyroptosis and its potential applications in cancer treatment. Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all mechanisms of PCD. Among these mechanisms, pyroptosis is mediated by the gasdermin family, accompanied by inflammatory and immune responses. The relationship between pyroptosis and cancer is complex, and the effects of pyroptosis on cancer vary in different tissues and genetic backgrounds. On one hand, pyroptosis can inhibit the occurrence and development of tumors; on the other hand, as a type of proinflammatory death, pyroptosis can form a suitable microenvironment for tumor cell growth and thus promote tumor growth. In addition, the induction of tumor pyroptosis is also considered a potential cancer treatment strategy. Studies have shown that DFNA5 (nonsyndromic hearing impairment protein 5)/GSDME (Gasdermin-E) mRNA methylation results in lower expression levels of DFNA5/GSDME in most tumor cells than in normal cells, making it difficult to activate the pyroptosis in most tumor cells. During the treatment of malignant tumors, appropriate chemotherapeutic drugs can be selected according to the expression levels of DFNA5/GSDME, which can be upregulated in tumor cells, thereby increasing the sensitivity to chemotherapeutic drugs and reducing drug resistance. Therefore, induced pyroptosis may play a predominant role in the treatment of cancer. Here, we review the latest research on the anti- and protumor effects of pyroptosis and its potential applications in cancer treatment.
ArticleNumber	650
Author	Jiang, Jinqing Cheng, Zhe Wang, Xin Qin, Wanhai Xia, Xiaojing Lei, Liancheng Hu, Jianhe
Author_xml	– sequence: 1 givenname: Xiaojing orcidid: 0000-0001-7717-8411 surname: Xia fullname: Xia, Xiaojing email: quik500@163.com organization: College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology – sequence: 2 givenname: Xin surname: Wang fullname: Wang, Xin organization: College of Agriculture and Forestry Science, Linyi University – sequence: 3 givenname: Zhe surname: Cheng fullname: Cheng, Zhe organization: College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology – sequence: 4 givenname: Wanhai surname: Qin fullname: Qin, Wanhai organization: Amsterdam UMC, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam Infection and Immunity – sequence: 5 givenname: Liancheng surname: Lei fullname: Lei, Liancheng organization: College of Veterinary Medicine, Jilin University – sequence: 6 givenname: Jinqing surname: Jiang fullname: Jiang, Jinqing organization: College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology – sequence: 7 givenname: Jianhe surname: Hu fullname: Hu, Jianhe organization: College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31501419$$D View this record in MEDLINE/PubMed
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Snippet	Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and...
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SubjectTerms	13/95 38/77 631/67 692/699/67 Animals Antibodies Apoptosis Apoptosis - genetics Apoptosis - physiology Autophagy Biochemistry Biomedical and Life Sciences Cancer Cancer therapies Cell Biology Cell Culture Cell death Drug resistance Hearing loss Hearing Loss, Sensorineural - genetics Hearing Loss, Sensorineural - metabolism Humans Immune response Immunology Immunosuppressive agents Inflammation Life Sciences mRNA Phagocytosis Pyroptosis Pyroptosis - genetics Pyroptosis - physiology Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Review Review Article RNA, Messenger - metabolism Tumor cells Tumors
Title	The role of pyroptosis in cancer: pro-cancer or pro-“host”?
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