Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study

Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measu...

Full description

Saved in:

Bibliographic Details
Published in:	European heart journal Vol. 29; no. 8; p. 1049
Main Authors:	Tzoulaki, Ioanna, Jarvelin, Marjo-Riitta, Hartikainen, Anna-Liisa, Leinonen, Maija, Pouta, Anneli, Paldanius, Mika, Ruokonen, Aimo, Canoy, Dexter, Sovio, Ulla, Saikku, Pekka, Elliott, Paul
Format:	Journal Article
Language:	English
Published:	England 01.04.2008
Subjects:	Adolescent Adult Birth Weight - physiology Body Height - physiology Body Mass Index C-Reactive Protein - metabolism Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Epidemiologic Methods Female Finland - epidemiology Humans Inflammation - complications Inflammation - epidemiology Inflammation - physiopathology Male Weight Gain - physiology Finland
ISSN:	0195-668X
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.
AbstractList	Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years.AIMSLow-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years.General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years.METHODS AND RESULTSGeneral population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years.Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.CONCLUSIONSystemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.
Author	Ruokonen, Aimo Pouta, Anneli Canoy, Dexter Tzoulaki, Ioanna Hartikainen, Anna-Liisa Elliott, Paul Paldanius, Mika Jarvelin, Marjo-Riitta Sovio, Ulla Leinonen, Maija Saikku, Pekka
Author_xml	– sequence: 1 givenname: Ioanna surname: Tzoulaki fullname: Tzoulaki, Ioanna organization: Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, W2 1PG, London, UK – sequence: 2 givenname: Marjo-Riitta surname: Jarvelin fullname: Jarvelin, Marjo-Riitta – sequence: 3 givenname: Anna-Liisa surname: Hartikainen fullname: Hartikainen, Anna-Liisa – sequence: 4 givenname: Maija surname: Leinonen fullname: Leinonen, Maija – sequence: 5 givenname: Anneli surname: Pouta fullname: Pouta, Anneli – sequence: 6 givenname: Mika surname: Paldanius fullname: Paldanius, Mika – sequence: 7 givenname: Aimo surname: Ruokonen fullname: Ruokonen, Aimo – sequence: 8 givenname: Dexter surname: Canoy fullname: Canoy, Dexter – sequence: 9 givenname: Ulla surname: Sovio fullname: Sovio, Ulla – sequence: 10 givenname: Pekka surname: Saikku fullname: Saikku, Pekka – sequence: 11 givenname: Paul surname: Elliott fullname: Elliott, Paul
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18403494$$D View this record in MEDLINE/PubMed
BookMark	eNo1UDtPwzAQ9lBEH7AzoZuYGrDzcG02qCggITEAElvl2pfGVWIXxwGVX8DPJhVludPpe9ynb0wGzjsk5IzRS0ZldoVdqFCFuLnCyjFaDMiIMlkknIv3IRm37YZSKjjjx2TIRE6zXOYj8vNivxFUhJUNsZrCF9p1FWGtrAP_iQFihVDbEkH7LrQ4BeUM1P4rWQdlEKwra9U0Klrv-gN2vnNrUKarY-W9uQbne18MDhbW1Xstk5zD7f4bzH3Vo9DGzuxOyFGp6hZPD3tC3hZ3r_OH5On5_nF-85ToIuMxUUyWOZuJdD808pLlmTZa6pwqwXSqqZ6tVpkouBY0NSYvMiGFzNMZV7QoTDohF3--2-A_OmzjsrGtxrrPhr5rl1wyyoTMeuL5gditGjTLbbCNCrvlf3fpL2KPc2s
CitedBy_id	crossref_primary_10_1007_s11154_013_9266_4 crossref_primary_10_1097_MOL_0b013e32831b4685 crossref_primary_10_1002_ajhb_21100 crossref_primary_10_1016_j_annepidem_2015_01_003 crossref_primary_10_3945_jn_110_128249 crossref_primary_10_1093_aje_kwp320 crossref_primary_10_1007_s00125_014_3479_2 crossref_primary_10_1073_pnas_1202244109 crossref_primary_10_1038_s41380_019_0395_3 crossref_primary_10_1186_1756_0500_4_71 crossref_primary_10_1016_j_socscimed_2015_11_040 crossref_primary_10_1016_j_clnesp_2023_02_028 crossref_primary_10_1136_bmjopen_2013_003167 crossref_primary_10_1017_S0033291717000745 crossref_primary_10_1172_JCI88882 crossref_primary_10_1210_jc_2008_2545 crossref_primary_10_1093_ije_dyq121 crossref_primary_10_1111_j_1467_789X_2012_01034_x crossref_primary_10_1371_journal_pone_0003013 crossref_primary_10_1113_JP285927 crossref_primary_10_1016_j_socscimed_2020_113592 crossref_primary_10_1073_pnas_2317232120 crossref_primary_10_1016_j_euroneuro_2015_05_003 crossref_primary_10_1002_ajhb_21092 crossref_primary_10_1097_MOL_0b013e3283541da6 crossref_primary_10_1038_ijo_2015_19 crossref_primary_10_2310_JIM_0b013e318200151a crossref_primary_10_1038_s41366_025_01718_4 crossref_primary_10_1161_CIRCULATIONAHA_110_987339 crossref_primary_10_1210_js_2017_00437 crossref_primary_10_3945_ajcn_2008_26779 crossref_primary_10_1002_oby_21311 crossref_primary_10_1007_s10995_011_0786_9 crossref_primary_10_1002_ajhb_22936 crossref_primary_10_1007_s12170_012_0271_z crossref_primary_10_1002_ajhb_22413 crossref_primary_10_1038_s41366_018_0087_0 crossref_primary_10_1073_pnas_1620661114 crossref_primary_10_1038_s41598_023_41065_w crossref_primary_10_1016_j_amepre_2010_05_014 crossref_primary_10_1038_ejcn_2013_75 crossref_primary_10_1111_eci_12606 crossref_primary_10_1016_j_eurpsy_2011_02_001 crossref_primary_10_1093_aje_kwr484 crossref_primary_10_1159_000441652 crossref_primary_10_1093_ajcn_nqaa056 crossref_primary_10_1161_JAHA_118_011524 crossref_primary_10_1016_j_earlhumdev_2016_05_015 crossref_primary_10_1093_aje_kwq027 crossref_primary_10_1016_j_psyneuen_2021_105280 crossref_primary_10_1038_s41598_019_52018_7 crossref_primary_10_1016_S0140_6736_19_32472_9 crossref_primary_10_1017_gheg_2016_9 crossref_primary_10_1186_s12888_023_04953_z crossref_primary_10_1038_ng_271 crossref_primary_10_1007_s00213_015_3975_1 crossref_primary_10_1371_journal_pone_0090357 crossref_primary_10_1017_S2040174411000018 crossref_primary_10_1093_ije_dyw255 crossref_primary_10_1161_JAHA_116_003262 crossref_primary_10_1017_S2040174417000502 crossref_primary_10_1111_obr_13138 crossref_primary_10_1017_S0954579418000330 crossref_primary_10_1002_ajhb_20852 crossref_primary_10_1016_j_neubiorev_2017_08_002 crossref_primary_10_1007_s10802_021_00859_0
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1093/eurheartj/ehn105
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
ExternalDocumentID	18403494
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Finland
GeographicLocations_xml	– name: Finland
GrantInformation_xml	– fundername: Wellcome Trust
GroupedDBID	--- --K -E4 .2P .GJ .I3 .XZ .ZR 08P 0R~ 18M 1B1 1TH 29G 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAFWJ AAJKP AAJQQ AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAWDT ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNGD ABNHQ ABNKS ABOCM ABPQP ABPTD ABQLI ABQNK ABSMQ ABVGC ABWST ABXVV ABZBJ ACFRR ACGFO ACGFS ACPQN ACPRK ACUFI ACUKT ACUTJ ACUTO ACVCV ACYHN ACZBC ADBBV ADEYI ADEZT ADGHP ADGZP ADHKW ADHZD ADIPN ADMTO ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEHUL AEJOX AEKPW AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFQV AFFZL AFIYH AFOFC AFSHK AFXAL AFYAG AGINJ AGKEF AGKRT AGMDO AGORE AGQPQ AGQXC AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJBYB AJDVS AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS ASPBG ATGXG ATTQO AVNTJ AVWKF AXUDD AZFZN BAWUL BAYMD BCGUY BCRHZ BEYMZ BHONS BTRTY BVRKM BZKNY C1A C45 CAG CDBKE CGR COF CS3 CUY CVF CZ4 DAKXR DIK DILTD D~K E3Z EBS ECM EE~ EIF EIHJH EJD EMOBN ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HVGLF HW0 HZ~ IHE IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z M41 MBLQV MHKGH ML0 N4W N9A NGC NOMLY NOYVH NPM NQ- NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OB3 OBFPC OCZFY ODMLO OGROG OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RIG RNI ROL ROX ROZ RPZ RUSNO RW1 RXO RZF SEL TCURE TEORI TJX TMA UHS VH1 W8F WOQ X7H YAYTL YKOAZ YXANX ZGI ZKX ~91 7X8
ID	FETCH-LOGICAL-c536t-a19f417824178ce6f143cdc9c40a81c2c0c7bb3856c802dd45389894276a055d2
IEDL.DBID	7X8
ISICitedReferencesCount	84
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000255150800017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0195-668X
IngestDate	Sun Sep 28 06:13:51 EDT 2025 Mon Jul 21 05:55:04 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c536t-a19f417824178ce6f143cdc9c40a81c2c0c7bb3856c802dd45389894276a055d2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://academic.oup.com/eurheartj/article-pdf/29/8/1049/17048470/ehn105.pdf
PMID	18403494
PQID	69101893
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_69101893 pubmed_primary_18403494
PublicationCentury	2000
PublicationDate	2008-04-01
PublicationDateYYYYMMDD	2008-04-01
PublicationDate_xml	– month: 04 year: 2008 text: 2008-04-01 day: 01
PublicationDecade	2000
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	European heart journal
PublicationTitleAlternate	Eur Heart J
PublicationYear	2008
SSID	ssj0008616
Score	2.2238984
Snippet	Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1049
SubjectTerms	Adolescent Adult Birth Weight - physiology Body Height - physiology Body Mass Index C-Reactive Protein - metabolism Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Epidemiologic Methods Female Finland - epidemiology Humans Inflammation - complications Inflammation - epidemiology Inflammation - physiopathology Male Weight Gain - physiology
Title	Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study
URI	https://www.ncbi.nlm.nih.gov/pubmed/18403494 https://www.proquest.com/docview/69101893
Volume	29
WOSCitedRecordID	wos000255150800017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwELUKRYgLlI9CgZY5cKy1ySZxbISEoOqqB7qqxIf2tnKccTeockqaUsEv6M_ujJMVJ8ShF0tRZCWKnyfPnvF7QrwtfVJlOrcy0ZWXeVWgNFmFMvMFYmnTrIregN8_l_O5XizMyYZ4vz4Lw2WV65gYA3XdOt4jnyjD2lIm-3D-U7JnFOdWRwONO2IzIyLDmC4Xf7XCtYrGp9GNUCm9GJOUtISf4GXHftH9jwmuQpoU_6aX8Tcze3S7F9wSD0d6CR8HPDwWGxieiPvHYwL9qbj-0vxBsD1UTdev9uEq7ozCqW0CcDEnEB-Es8YjuJbLO_bBhhrO2it52tkagfBIEBqOO9IF_OZgAVHEg_WR30HgPBB2AWZN4KJJoLmn4BM_DQ7aFd2FqGj7THybHX49OJKjGYN0RaZ6aVPj85T4BDcOlSei5WpnXJ5YnbqpS1xZ0bAXyulkWtc5RVIWd5-WyiZFUU-3xd3QBnwhQOfaMwioQ5ZbU2jijESUPOrUGtRmR7xZf-ElgZ0zGDZge3mxXH_jHfF8GKTl-aDJseSFKivtvPxv31fiwVDzwdU3r8Wmp2mOu-Ke-9U3F91exBC185PjGzW30xA
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Size+at+birth%2C+weight+gain+over+the+life+course%2C+and+low-grade+inflammation+in+young+adulthood%3A+northern+Finland+1966+Birth+Cohort+study&rft.jtitle=European+heart+journal&rft.au=Tzoulaki%2C+Ioanna&rft.au=Jarvelin%2C+Marjo-Riitta&rft.au=Hartikainen%2C+Anna-Liisa&rft.au=Leinonen%2C+Maija&rft.date=2008-04-01&rft.issn=0195-668X&rft.volume=29&rft.issue=8&rft.spage=1049&rft_id=info:doi/10.1093%2Feurheartj%2Fehn105&rft_id=info%3Apmid%2F18403494&rft_id=info%3Apmid%2F18403494&rft.externalDocID=18403494
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0195-668X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0195-668X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0195-668X&client=summon