Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study

Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measu...

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Vydáno v:	European heart journal Ročník 29; číslo 8; s. 1049
Hlavní autoři:	Tzoulaki, Ioanna, Jarvelin, Marjo-Riitta, Hartikainen, Anna-Liisa, Leinonen, Maija, Pouta, Anneli, Paldanius, Mika, Ruokonen, Aimo, Canoy, Dexter, Sovio, Ulla, Saikku, Pekka, Elliott, Paul
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.04.2008
Témata:	Adolescent Adult Birth Weight - physiology Body Height - physiology Body Mass Index C-Reactive Protein - metabolism Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Epidemiologic Methods Female Finland - epidemiology Humans Inflammation - complications Inflammation - epidemiology Inflammation - physiopathology Male Weight Gain - physiology Finland
ISSN:	0195-668X
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Abstract	Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.
AbstractList	Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years.AIMSLow-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years.General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years.METHODS AND RESULTSGeneral population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years.Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.CONCLUSIONSystemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults. Low-grade inflammation might mediate associations between size at birth, early life growth, excessive weight gain, and subsequent risk of cardiovascular disease in adult life. Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years. General population-based northern Finland 1966 Birth Cohort study of 5840 participants attending a clinical examination at 31 years, including measurement of CRP. Weight and height were assessed at birth, 12 months, and 14 and 31 years of age. CRP levels at 31 years were 16% [95% confidence interval (CI) 8, 23] higher per 1 kg lower birth weight, 21% (95% CI 2, 37) higher per 10 cm lower birth length, and 24% (95% CI 10, 36) higher per 1 kg/m3 lower ponderal index, after adjustment for potential confounders. Participants with highest tertile body mass index (BMI) at 31 years and lowest tertile birth weight had the highest average CRP levels. Per unit increase in BMI from 14 to 31 years was associated with 16% (95% CI 14, 17) higher CRP levels; the association was larger for those in the top BMI tertile at age 14 years. Systemic low-grade inflammation may lie on the causal pathway that relates impaired fetal growth and weight gain from childhood to adulthood to adverse adult cardiovascular health. Lifestyle changes from early life might be an important step in reducing cardiovascular risk in adults.
Author	Ruokonen, Aimo Pouta, Anneli Canoy, Dexter Tzoulaki, Ioanna Hartikainen, Anna-Liisa Elliott, Paul Paldanius, Mika Jarvelin, Marjo-Riitta Sovio, Ulla Leinonen, Maija Saikku, Pekka
Author_xml	– sequence: 1 givenname: Ioanna surname: Tzoulaki fullname: Tzoulaki, Ioanna organization: Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, W2 1PG, London, UK – sequence: 2 givenname: Marjo-Riitta surname: Jarvelin fullname: Jarvelin, Marjo-Riitta – sequence: 3 givenname: Anna-Liisa surname: Hartikainen fullname: Hartikainen, Anna-Liisa – sequence: 4 givenname: Maija surname: Leinonen fullname: Leinonen, Maija – sequence: 5 givenname: Anneli surname: Pouta fullname: Pouta, Anneli – sequence: 6 givenname: Mika surname: Paldanius fullname: Paldanius, Mika – sequence: 7 givenname: Aimo surname: Ruokonen fullname: Ruokonen, Aimo – sequence: 8 givenname: Dexter surname: Canoy fullname: Canoy, Dexter – sequence: 9 givenname: Ulla surname: Sovio fullname: Sovio, Ulla – sequence: 10 givenname: Pekka surname: Saikku fullname: Saikku, Pekka – sequence: 11 givenname: Paul surname: Elliott fullname: Elliott, Paul
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SubjectTerms	Adolescent Adult Birth Weight - physiology Body Height - physiology Body Mass Index C-Reactive Protein - metabolism Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Epidemiologic Methods Female Finland - epidemiology Humans Inflammation - complications Inflammation - epidemiology Inflammation - physiopathology Male Weight Gain - physiology
Title	Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study
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