Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant

Posttransplant vaccination targeting residual disease is an immunotherapeutic strategy to improve antigen-specific immune responses and prolong disease-free survival after autologous stem cell transplantation (ASCT) for multiple myeloma (MM). We conducted a phase 1 vaccine trial to determine the saf...

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Bibliographic Details

Published in:	Blood advances Vol. 6; no. 5; pp. 1547 - 1558
Main Authors:	Chung, David J., Sharma, Sneh, Rangesa, Madhumitha, DeWolf, Susan, Elhanati, Yuval, Perica, Karlo, Young, James W.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 08.03.2022 American Society of Hematology
Subjects:	Antigens, Neoplasm Autografts Cancer Vaccines - adverse effects Clinical Trials and Observations Dendritic Cells Hematopoietic Stem Cell Transplantation Humans Lenalidomide Multiple Myeloma RNA, Messenger - genetics Transplantation, Autologous
ISSN:	2473-9529, 2473-9537, 2473-9537
Online Access:	Get full text
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