Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant

Posttransplant vaccination targeting residual disease is an immunotherapeutic strategy to improve antigen-specific immune responses and prolong disease-free survival after autologous stem cell transplantation (ASCT) for multiple myeloma (MM). We conducted a phase 1 vaccine trial to determine the saf...

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Veröffentlicht in:	Blood advances Jg. 6; H. 5; S. 1547 - 1558
Hauptverfasser:	Chung, David J., Sharma, Sneh, Rangesa, Madhumitha, DeWolf, Susan, Elhanati, Yuval, Perica, Karlo, Young, James W.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 08.03.2022 American Society of Hematology
Schlagworte:	Antigens, Neoplasm Autografts Cancer Vaccines - adverse effects Clinical Trials and Observations Dendritic Cells Hematopoietic Stem Cell Transplantation Humans Lenalidomide Multiple Myeloma RNA, Messenger - genetics Transplantation, Autologous
ISSN:	2473-9529, 2473-9537, 2473-9537
Online-Zugang:	Volltext
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