Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients

Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on...

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Bibliographic Details
Published in:	Translational psychiatry Vol. 9; no. 1; pp. 173 - 14
Main Authors:	Bhattacharyya, Sudeepa, Ahmed, Ahmed T., Arnold, Matthias, Liu, Duan, Luo, Chunqiao, Zhu, Hongjie, Mahmoudiandehkordi, Siamak, Neavin, Drew, Louie, Gregory, Dunlop, Boadie W., Frye, Mark A., Wang, Liewei, Weinshilboum, Richard M., Krishnan, Ranga R., Rush, A. John, Kaddurah-Daouk, Rima
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.07.2019 Nature Publishing Group
Subjects:	692/699/476/1414 706/648 Acids Adult Behavioral Sciences Biological Psychology Citalopram - pharmacology Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Female Follow-Up Studies Gastrointestinal Microbiome - drug effects Humans Male Medicine Medicine & Public Health Metabolites Metabolome - drug effects Metabolomics Middle Aged Neurosciences Pharmacotherapy Psychiatry Serotonin Uptake Inhibitors - pharmacology Severity of Illness Index Signal Transduction - drug effects
ISSN:	2158-3188, 2158-3188
Online Access:	Get full text
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