Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known...

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Veröffentlicht in:	Cellular & molecular immunology Jg. 17; H. 6; S. 613 - 620
Hauptverfasser:	Tai, Wanbo, He, Lei, Zhang, Xiujuan, Pu, Jing, Voronin, Denis, Jiang, Shibo, Zhou, Yusen, Du, Lanying
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	China Nature Publishing Group 01.06.2020
Schlagworte:	ACE2 Amino Acid Sequence Angiotensin Angiotensin-converting enzyme 2 Animals Antibodies Antibodies, Viral - immunology Antisera Betacoronavirus - immunology Betacoronavirus - metabolism Binding Sites Chiroptera Coronaviridae Coronavirus Infections - immunology Coronavirus Infections - metabolism Coronavirus Infections - prevention & control Coronavirus Infections - therapy Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Vaccines Cross Reactions HEK293 Cells Humans Infections Mice Pandemics Peptidyl-dipeptidase A Pneumonia, Viral - immunology Pneumonia, Viral - metabolism Pneumonia, Viral - therapy Pneumonia, Viral - virology Protein Binding Proteins Public health Receptor, Angiotensin, Type 2 - metabolism SARS Virus - immunology SARS Virus - metabolism SARS-CoV-2 Sequence Alignment Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Vaccines Viral Vaccines - immunology Viral Vaccines - metabolism Virus attachment Virus Internalization SARS-CoV-2 cross-neutralization 2019 novel coronavirus viral inhibitor receptor-binding domain spike protein
ISSN:	1672-7681, 2042-0226, 2042-0226
Online-Zugang:	Volltext
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