The diagnostic accuracy of OCT angiography in naive and treated neovascular age-related macular degeneration: a review

Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in...

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Veröffentlicht in:Eye (London) Jg. 33; H. 2; S. 274 - 282
Hauptverfasser: Perrott-Reynolds, Rhianon, Cann, Robert, Cronbach, Nicola, Neo, Yan Ning, Ho, Vivian, McNally, Orla, Madi, Haifa A, Cochran, Claire, Chakravarthy, Usha
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.02.2019
Schlagworte:
Age
Angiogenesis Inhibitors - therapeutic use
Angiography
Choroidal Neovascularization - diagnosis
Choroidal Neovascularization - drug therapy
Dyes
Fluorescein
Fluorescein Angiography - methods
Humans
Image processing
Macular degeneration
Medical imaging
Reproducibility of Results
Retina
Segmentation
Sensitivity and Specificity
Tomography, Optical Coherence - methods
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Visual Acuity - physiology
Wet Macular Degeneration - diagnosis
Wet Macular Degeneration - drug therapy
ISSN:0950-222X, 1476-5454, 1476-5454
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Abstract Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.
AbstractList Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.
Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal vasculature. Of clinical importance is its current use either as an alternative or in conjunction with conventional dye-based angiography in neovascular age-related macular degeneration. OCTA is not without limitations and these include image artefact, a relatively small field of view and failure of the segmentation algorithms, which can confound the interpretation of findings. While there are numerous publications on OCTA in neovascular AMD, few have examined the diagnostic accuracy of this new technology compared with the accepted gold standard of fundus fluorescein angiography (FFA). In this review, we summarise the literature on the clinical application of OCTA in nAMD. In particular, we have reviewed the published articles that have reported the sensitivity and specificity of OCTA in the diagnosis of nAMD, and those that have described and or correlated the morphological findings and compared them to dye-based angiography.
Author Ho, Vivian
Neo, Yan Ning
Cronbach, Nicola
Cochran, Claire
Chakravarthy, Usha
McNally, Orla
Cann, Robert
Madi, Haifa A
Perrott-Reynolds, Rhianon
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  surname: Perrott-Reynolds
  fullname: Perrott-Reynolds, Rhianon
  email: Rhianon.reynolds@wales.nhs.uk
  organization: Department of Ophthalmology, University Hospital of Wales, Cardiff, CF14 4XW, UK. Rhianon.reynolds@wales.nhs.uk
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  givenname: Robert
  surname: Cann
  fullname: Cann, Robert
  organization: Mid Yorkshire Hospitals NHS Trust, West Yorkshire, WF1 4DG, UK
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  givenname: Nicola
  surname: Cronbach
  fullname: Cronbach, Nicola
  organization: Buckinghamshire Healthcare NHS trust, Oxford, UK
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  givenname: Yan Ning
  orcidid: 0000-0001-8319-7889
  surname: Neo
  fullname: Neo, Yan Ning
  organization: The Hillingdon Hospitals NHS Trust, Uxbridge, UB8 3NN, UK
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  fullname: Ho, Vivian
  organization: Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpoool, L14 3LB, UK
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  surname: McNally
  fullname: McNally, Orla
  organization: Belfast Health and Social Care Trust, Belfast, BT9 7AB, UK
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  givenname: Haifa A
  surname: Madi
  fullname: Madi, Haifa A
  organization: Sunderland Eye Infirmary, Sunderland, SR2 9HP, UK
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  givenname: Claire
  surname: Cochran
  fullname: Cochran, Claire
  organization: EDNA Study Team, University of Aberdeen, Aberdeen, AB25 2ZD, UK
– sequence: 9
  givenname: Usha
  surname: Chakravarthy
  fullname: Chakravarthy, Usha
  organization: Department of Ophthalmology, Belfast Health and Social Care Trust, Belfast, BT9 7AB, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30382236$$D View this record in MEDLINE/PubMed
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Snippet Optical coherence tomography angiography (OCTA) is a non-invasive retinal imaging innovation that has been gaining popularity for the evaluation of the retinal...
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SubjectTerms Age
Angiogenesis Inhibitors - therapeutic use
Angiography
Choroidal Neovascularization - diagnosis
Choroidal Neovascularization - drug therapy
Dyes
Fluorescein
Fluorescein Angiography - methods
Humans
Image processing
Macular degeneration
Medical imaging
Reproducibility of Results
Retina
Segmentation
Sensitivity and Specificity
Tomography, Optical Coherence - methods
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Visual Acuity - physiology
Wet Macular Degeneration - diagnosis
Wet Macular Degeneration - drug therapy
Title The diagnostic accuracy of OCT angiography in naive and treated neovascular age-related macular degeneration: a review
URI https://www.ncbi.nlm.nih.gov/pubmed/30382236
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