Green fluorescent protein based pH indicators for in vivo use: a review

Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics. GFP fluorescence is stable, species-independent,...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Analytical and bioanalytical chemistry Ročník 393; číslo 4; s. 1107 - 1122
Hlavní autoři: Bizzarri, Ranieri, Serresi, Michela, Luin, Stefano, Beltram, Fabio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.02.2009
Springer-Verlag
Témata:
absorption
Analytical Chemistry
Biochemistry
Biomedical materials
biosensors
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
dyes
Dynamics
Flow Cytometry
Fluorescence
fluorescence microscopy
Fluorescence/luminescence
Food Science
gene expression
green fluorescent protein
Green Fluorescent Proteins
Green Fluorescent Proteins - chemistry
Hydrogen-Ion Concentration
image analysis
In vivo tests
Indicators
Laboratory Medicine
Microscopy, Fluorescence
monitoring
Monitoring/Environmental Analysis
Optical sensors
pH measurements
phenol
Proteins
Review
Spectroscopy/theory
Surgical implants
Spectroscopy/theory
Biosensors
Optical sensors
Fluorescence/luminescence
pH measurements
ISSN:1618-2642, 1618-2650, 1618-2650
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics. GFP fluorescence is stable, species-independent, and can be monitored noninvasively in living cells by fluorescence microscopy, flow cytometry, or macroscopic imaging techniques. Owing to the presence of a phenol group on the chromophore, most GFP variants display pH-sensitive absorption and fluorescence bands. Such behavior has been exploited to genetically engineer encodable pH indicators for studies of pH regulation within specific intracellular compartments that cannot be probed using conventional pH-sensitive dyes. These pH indicators contributed to shedding light on a number of cell functions for which intracellular pH is an important modulator. In this review we discuss the photophysical properties that make GFPs so special as pH indicators for in vivo use and we describe the probes that are utilized most by the scientific community.
AbstractList Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics. GFP fluorescence is stable, species-independent, and can be monitored noninvasively in living cells by fluorescence microscopy, flow cytometry, or macroscopic imaging techniques. Owing to the presence of a phenol group on the chromophore, most GFP variants display pH-sensitive absorption and fluorescence bands. Such behavior has been exploited to genetically engineer encodable pH indicators for studies of pH regulation within specific intracellular compartments that cannot be probed using conventional pH-sensitive dyes. These pH indicators contributed to shedding light on a number of cell functions for which intracellular pH is an important modulator. In this review we discuss the photophysical properties that make GFPs so special as pH indicators for in vivo use and we describe the probes that are utilized most by the scientific community.
Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics. GFP fluorescence is stable, species-independent, and can be monitored noninvasively in living cells by fluorescence microscopy, flow cytometry, or macroscopic imaging techniques. Owing to the presence of a phenol group on the chromophore, most GFP variants display pH-sensitive absorption and fluorescence bands. Such behavior has been exploited to genetically engineer encodable pH indicators for studies of pH regulation within specific intracellular compartments that cannot be probed using conventional pH-sensitive dyes. These pH indicators contributed to shedding light on a number of cell functions for which intracellular pH is an important modulator. In this review we discuss the photophysical properties that make GFPs so special as pH indicators for in vivo use and we describe the probes that are utilized most by the scientific community.Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells and organisms, including gene expression, protein localization, and intracellular dynamics. GFP fluorescence is stable, species-independent, and can be monitored noninvasively in living cells by fluorescence microscopy, flow cytometry, or macroscopic imaging techniques. Owing to the presence of a phenol group on the chromophore, most GFP variants display pH-sensitive absorption and fluorescence bands. Such behavior has been exploited to genetically engineer encodable pH indicators for studies of pH regulation within specific intracellular compartments that cannot be probed using conventional pH-sensitive dyes. These pH indicators contributed to shedding light on a number of cell functions for which intracellular pH is an important modulator. In this review we discuss the photophysical properties that make GFPs so special as pH indicators for in vivo use and we describe the probes that are utilized most by the scientific community.
Author Bizzarri, Ranieri
Beltram, Fabio
Serresi, Michela
Luin, Stefano
Author_xml – sequence: 1
  fullname: Bizzarri, Ranieri
– sequence: 2
  fullname: Serresi, Michela
– sequence: 3
  fullname: Luin, Stefano
– sequence: 4
  fullname: Beltram, Fabio
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19034433$$D View this record in MEDLINE/PubMed
BookMark eNqNkk2LFDEQhoOsuB_6A7xoTuqltdL53pssOisseNA9h3Q6WbL0JGPSPeK_N0OvCh5GT1UFz1tV8L7n6CTl5BF6TuAtAZDvKkBPRAegup4T3ulH6IwI0ibB4eR3z_pTdF7rPQDhiogn6JRooIxReoY2m-J9wmFacvHV-TTjXcmzjwkPtvoR765xTGN0ds6l4pBLG_E-7jNeqr_EFhe_j_77U_Q42Kn6Zw_1At1-_PD16rq7-bz5dPX-pnOcirkTo7UD54McrGacKxu4GqQKnDvpFLVBMK76UQ2qFSDaOiFHLogOXmrlAr1Ar9e97ctvi6-z2cb29jTZ5PNSjWxnNAMmGvnqKCmE0oT9B8gEEVpI9k-Q0h64VoeNb46CRDImgQODhr54QJdh60ezK3Fryw_zy6EGkBVwJddafPiDgDmkwKwpMC0F5pACo5tG_qVxcbZzzGkuNk5Hlf2qrO1KuvPF3OelpOboUdHLVRRsNvauxGpuvzT3aMtb86Kn9Cc7w8w3
CitedBy_id crossref_primary_10_1021_ja404900k
crossref_primary_10_1016_j_ijfoodmicro_2012_03_028
crossref_primary_10_1039_C3CS60171D
crossref_primary_10_1007_s10043_010_0054_z
crossref_primary_10_1371_journal_pone_0053428
crossref_primary_10_1007_s00253_014_5975_1
crossref_primary_10_1002_bit_23019
crossref_primary_10_1088_1361_6528_abc208
crossref_primary_10_1155_2012_203734
crossref_primary_10_1016_j_aca_2013_05_022
crossref_primary_10_1073_pnas_1304056110
crossref_primary_10_2217_nnm_13_196
crossref_primary_10_1016_j_cbpa_2009_09_033
crossref_primary_10_1002_jms_5111
crossref_primary_10_1039_c4pp00212a
crossref_primary_10_1007_s11434_015_0942_5
crossref_primary_10_1038_nprot_2014_196
crossref_primary_10_1002_bit_26376
crossref_primary_10_1016_j_freeradbiomed_2016_06_018
crossref_primary_10_1038_s41598_018_29308_7
crossref_primary_10_1159_000452711
crossref_primary_10_3389_fphar_2023_1339518
crossref_primary_10_1016_j_bbagen_2018_09_013
crossref_primary_10_1007_s10812_017_0521_4
crossref_primary_10_1016_j_ijbiomac_2009_05_010
crossref_primary_10_1111_tra_12722
crossref_primary_10_1002_bab_1511
crossref_primary_10_1016_j_freeradbiomed_2016_12_004
crossref_primary_10_1016_S1004_9541_09_60140_3
crossref_primary_10_1016_j_neuron_2017_09_047
crossref_primary_10_1016_j_jbiotec_2017_05_006
crossref_primary_10_1039_c3pp50040c
crossref_primary_10_1002_bio_2497
crossref_primary_10_3390_ijms21114164
crossref_primary_10_1089_ars_2016_6747
crossref_primary_10_1016_j_bbagen_2015_05_001
crossref_primary_10_1002_bio_4716
crossref_primary_10_1016_j_bios_2023_115935
crossref_primary_10_1155_2012_868154
crossref_primary_10_1038_s41467_024_49941_3
crossref_primary_10_3390_v7112915
crossref_primary_10_1371_journal_pone_0048809
crossref_primary_10_1016_j_bbrc_2015_07_095
crossref_primary_10_1002_marc_202100720
crossref_primary_10_1016_j_jbiotec_2014_07_007
crossref_primary_10_1039_c2cc34267g
crossref_primary_10_3724_SP_J_1259_2015_00394
crossref_primary_10_1016_j_bbagen_2015_08_002
crossref_primary_10_1016_j_trac_2017_09_004
crossref_primary_10_1007_s10529_011_0767_5
crossref_primary_10_3390_ijms12074625
crossref_primary_10_1021_ja3064292
crossref_primary_10_3389_fcell_2022_1007893
crossref_primary_10_1016_j_aca_2017_07_040
crossref_primary_10_1016_j_freeradbiomed_2018_04_004
crossref_primary_10_1016_j_biocel_2020_105761
crossref_primary_10_1016_j_bbapap_2010_10_002
crossref_primary_10_1016_j_tplants_2023_06_015
crossref_primary_10_1080_09168451_2018_1451739
crossref_primary_10_3233_BPL_160029
crossref_primary_10_1016_j_bbagen_2011_03_011
crossref_primary_10_1007_s00604_018_3027_8
crossref_primary_10_1016_j_ijfoodmicro_2015_07_003
crossref_primary_10_3389_fbioe_2019_00005
crossref_primary_10_1371_journal_pone_0064753
crossref_primary_10_1007_s10856_020_06449_8
crossref_primary_10_3390_bios12050271
crossref_primary_10_1134_S1068162015060114
crossref_primary_10_1002_ange_202101731
crossref_primary_10_1016_j_abb_2025_110350
crossref_primary_10_1021_ja804504b
crossref_primary_10_1016_j_jneumeth_2010_08_002
crossref_primary_10_1371_journal_pone_0110750
crossref_primary_10_1021_ja202902d
crossref_primary_10_1016_j_neuron_2010_11_035
crossref_primary_10_1038_s41467_017_00606_4
crossref_primary_10_1111_jnc_12639
crossref_primary_10_1007_s11240_020_01765_x
crossref_primary_10_1007_s00216_013_6860_y
crossref_primary_10_1002_cbic_201800050
crossref_primary_10_1242_jcs_198564
crossref_primary_10_1021_ja409971k
crossref_primary_10_3390_s131216736
crossref_primary_10_1002_biot_201500056
crossref_primary_10_1016_j_fm_2018_03_006
crossref_primary_10_1007_s12011_009_8476_9
crossref_primary_10_3390_chemosensors10090354
crossref_primary_10_1007_s00604_017_2352_7
crossref_primary_10_1189_jlb_1012544
crossref_primary_10_1002_chem_201703560
crossref_primary_10_1016_j_snb_2017_10_037
crossref_primary_10_1039_c2cc30373f
crossref_primary_10_1111_pim_12608
crossref_primary_10_1007_s00216_013_7084_x
crossref_primary_10_1089_ars_2015_6586
crossref_primary_10_1016_j_actbio_2020_05_014
crossref_primary_10_1002_cbic_201402075
crossref_primary_10_1016_j_bbabio_2014_04_003
crossref_primary_10_1080_15548627_2015_1084455
crossref_primary_10_1038_s41598_017_05338_5
crossref_primary_10_1016_j_bios_2023_115467
crossref_primary_10_1039_c003167d
crossref_primary_10_7554_eLife_46135
crossref_primary_10_1038_s41598_017_09426_4
crossref_primary_10_3389_fbioe_2019_00279
crossref_primary_10_1016_j_cbpa_2015_05_024
crossref_primary_10_1002_cphc_200800839
crossref_primary_10_1080_15384101_2021_1949106
crossref_primary_10_1016_j_cej_2022_134801
crossref_primary_10_1002_anie_202101731
Cites_doi 10.1002/jcp.1030590302
10.1152/physiol.00035.2006
10.1021/jp0362077
10.1002/cyto.a.10028
10.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-3
10.1110/ps.073112007
10.1021/jp801164n
10.1016/j.ejphar.2003.12.016
10.1002/cphc.200500005
10.1038/nbt899
10.1021/bi992675o
10.1186/1475-925X-5-36
10.1006/bbrc.2001.6004
10.1016/S0021-9258(19)83641-4
10.1016/S0006-3495(00)76468-X
10.1007/978-1-4757-3061-6
10.1021/bi026609p
10.1034/j.1600-0854.2002.30906.x
10.1083/jcb.127.3.693
10.1126/science.273.5280.1392
10.1038/28190
10.1152/ajpcell.00008.2003
10.1007/s00424-008-0497-2
10.1021/bi00262a003
10.1038/nrm976
10.1242/jcs.114.5.837
10.1364/AO.37.007352
10.1074/jbc.M102815200
10.1074/jbc.272.42.26545
10.1074/jbc.M109003200
10.1021/jp011430u
10.1529/biophysj.105.074708
10.1002/cbic.200300595
10.1016/0968-4328(93)90034-X
10.1083/jcb.95.1.189
10.1073/pnas.95.23.13573
10.1021/bi9902182
10.1016/S0301-0104(99)00256-6
10.1016/j.jneumeth.2007.12.016
10.1016/j.neuron.2006.05.019
10.1074/jbc.M306766200
10.1186/1746-4811-2-7
10.1016/S0301-0104(98)00080-9
10.1038/10763
10.1529/biophysj.105.062836
10.1016/j.biocel.2004.02.006
10.1039/b800391b
10.1242/jcs.114.16.2929
10.1021/jp026454v
10.1073/pnas.95.12.6803
10.2144/000112798
10.1021/ar040086r
10.1016/S0006-3495(99)77097-9
10.1021/ja0580439
10.1103/PhysRevE.70.030901
10.1111/j.1600-0854.2007.00696.x
10.1006/jmbi.2000.3905
10.1016/j.tibtech.2005.10.005
10.1073/pnas.94.6.2306
10.1016/S0301-0104(01)00486-4
10.1073/pnas.0404262102
10.1016/j.gene.2003.10.018
10.1038/nature03692
10.1016/S0092-8674(00)81687-6
10.1016/0378-1119(92)90691-H
10.1038/nbt895
10.1083/jcb.200208050
10.1016/S0091-679X(08)60978-4
10.1021/bi7009037
10.1016/S0006-3495(97)78102-5
10.1083/jcb.115.6.1505
10.1016/S0969-2126(98)00127-0
10.1074/jbc.M308099200
10.1021/bi602646r
10.1038/sj.mt.6300172
10.1021/ja053909w
10.1021/ja045400r
10.1016/S0092-8674(03)00112-0
10.1074/jbc.275.9.6047
10.1529/biophysj.107.111773
10.1002/cphc.200400318
10.1073/pnas.93.16.8362
10.1002/0471739499.ch6
10.1073/pnas.93.24.13617
10.1016/S0006-3495(98)77870-1
10.1016/0968-4328(93)90035-Y
10.1074/jbc.M412327200
10.1146/annurev.biochem.67.1.509
10.1126/science.8303295
10.1021/jp9942522
10.1021/ja063128a
10.1021/ja0754507
10.1007/s00216-008-2489-7
10.1038/nmeth819
10.1021/bi026610o
10.1016/j.neuron.2005.10.003
10.1074/jbc.274.12.8093
10.1529/biophysj.106.102319
10.1159/000091235
10.1529/biophysj.107.114645
10.1016/S0014-5793(02)02535-8
ContentType Journal Article
Copyright Springer-Verlag 2008
Copyright_xml – notice: Springer-Verlag 2008
DBID FBQ
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7SR
7U5
8BQ
8FD
JG9
L7M
7S9
L.6
7X8
7QH
7UA
C1K
DOI 10.1007/s00216-008-2515-9
DatabaseName AGRIS
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
Materials Research Database
Advanced Technologies Database with Aerospace
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
Aqualine
Water Resources Abstracts
Environmental Sciences and Pollution Management
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Materials Research Database
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
METADEX
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
Aqualine
Water Resources Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList
Aqualine
AGRICOLA
Materials Research Database
MEDLINE
MEDLINE - Academic
Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1618-2650
EndPage 1122
ExternalDocumentID 19034433
10_1007_s00216_008_2515_9
US201301594023
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
-Y2
-~C
.86
.VR
06C
06D
0R~
0VY
199
1N0
203
23M
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
4.4
406
408
409
40D
40E
53G
5VS
67Z
6NX
78A
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
A8Z
AAAVM
AABHQ
AACDK
AAHBH
AAHNG
AAIAL
AAIKT
AAJBT
AAJKR
AANZL
AAPKM
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYOK
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBXA
ABDBE
ABDBF
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABIPD
ABJCF
ABJNI
ABJOX
ABKCH
ABKTR
ABLJU
ABMNI
ABMQK
ABNWP
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACAOD
ACBXY
ACDTI
ACGFS
ACHSB
ACHXU
ACIWK
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACPRK
ACUHS
ACZOJ
ADBBV
ADHIR
ADHKG
ADIMF
ADJJI
ADKNI
ADKPE
ADPHR
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEUYN
AEVLU
AEXYK
AFBBN
AFEXP
AFGCZ
AFKRA
AFLOW
AFQWF
AFRAH
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHIZS
AHKAY
AHMBA
AHPBZ
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AYFIA
AYJHY
AZFZN
B-.
B0M
BA0
BBNVY
BDATZ
BENPR
BGLVJ
BGNMA
BHPHI
BPHCQ
BSONS
BVXVI
CAG
CCPQU
COF
CS3
CSCUP
D1I
DDRTE
DL5
DNIVK
DPUIP
EAD
EAP
EBD
EBLON
EBS
EIOEI
EJD
EMK
EMOBN
EPAXT
EPL
ESBYG
ESX
F5P
FBQ
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ7
GQ8
GXS
H13
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
H~9
I09
IAO
IGS
IHE
IHR
IJ-
IKXTQ
IMOTQ
INH
INR
ITC
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KB.
KDC
KOV
LAS
LK8
LLZTM
M1P
M4Y
M7P
MA-
ML-
N2Q
N9A
NB0
NDZJH
NPVJJ
NQJWS
NU0
O93
O9G
O9I
O9J
OAM
P19
P2P
P9N
PDBOC
PF0
PHGZT
PQQKQ
PROAC
PSQYO
PT4
PT5
QOK
QOR
QOS
R89
R9I
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZK
S16
S1Z
S26
S27
S28
S3B
SAP
SCLPG
SCM
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
STPWE
SV3
SZN
T13
T16
TSG
TSK
TSV
TUC
TUS
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
W4F
WH7
WJK
WK8
YLTOR
Z45
Z8Z
ZMTXR
~8M
~KM
-58
-5G
-BR
-EM
3V.
ADINQ
GQ6
IFM
Z5O
Z7R
Z7S
Z7U
Z7V
Z7W
Z7X
Z7Y
Z7Z
Z81
Z82
Z83
Z85
Z86
Z87
Z88
Z8M
Z8N
Z8O
Z8P
Z8Q
Z8R
Z8S
Z8T
Z8U
Z8V
Z8W
Z91
Z92
AAYXX
ABBRH
ABFSG
ABRTQ
ACSTC
AEZWR
AFDZB
AFFHD
AFHIU
AFOHR
AGQPQ
AHWEU
AIXLP
ATHPR
CITATION
PHGZM
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7SR
7U5
8BQ
8FD
ESTFP
JG9
L7M
7S9
L.6
7X8
7QH
7UA
C1K
ID FETCH-LOGICAL-c536t-6daab55b7ba94558af58b78f55c7c83af64582d8b8582019ac67d5619fe798cf3
IEDL.DBID RSV
ISICitedReferencesCount 152
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000263127500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1618-2642
1618-2650
IngestDate Tue Oct 07 09:50:26 EDT 2025
Sun Nov 09 11:23:15 EST 2025
Thu Oct 02 10:12:28 EDT 2025
Mon Sep 08 17:02:51 EDT 2025
Wed Oct 01 13:48:44 EDT 2025
Mon Jul 21 05:58:53 EDT 2025
Sat Nov 29 06:44:10 EST 2025
Tue Nov 18 20:15:34 EST 2025
Fri Feb 21 02:33:39 EST 2025
Thu Apr 03 09:46:37 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Spectroscopy/theory
Biosensors
Optical sensors
Fluorescence/luminescence
pH measurements
Language English
License http://www.springer.com/tdm
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c536t-6daab55b7ba94558af58b78f55c7c83af64582d8b8582019ac67d5619fe798cf3
Notes http://dx.doi.org/10.1007/s00216-008-2515-9
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ObjectType-Review-3
OpenAccessLink http://hdl.handle.net/11384/8996
PMID 19034433
PQID 1744705040
PQPubID 23500
PageCount 16
ParticipantIDs proquest_miscellaneous_753694046
proquest_miscellaneous_66891446
proquest_miscellaneous_46169674
proquest_miscellaneous_33205986
proquest_miscellaneous_1744705040
pubmed_primary_19034433
crossref_primary_10_1007_s00216_008_2515_9
crossref_citationtrail_10_1007_s00216_008_2515_9
springer_journals_10_1007_s00216_008_2515_9
fao_agris_US201301594023
PublicationCentury 2000
PublicationDate 2009-02-01
PublicationDateYYYYMMDD 2009-02-01
PublicationDate_xml – month: 02
  year: 2009
  text: 2009-02-01
  day: 01
PublicationDecade 2000
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Germany
PublicationTitle Analytical and bioanalytical chemistry
PublicationTitleAbbrev Anal Bioanal Chem
PublicationTitleAlternate Anal Bioanal Chem
PublicationYear 2009
Publisher Berlin/Heidelberg : Springer-Verlag
Springer-Verlag
Publisher_xml – name: Berlin/Heidelberg : Springer-Verlag
– name: Springer-Verlag
References JayaramanSHaggiePWachterRMRemingtonSJVerkmanASJ Biol Chem20002756047605010.1074/jbc.275.9.60471:CAS:528:DC%2BD3cXhslWrsrs%3D
PaddockSBiotechniques20084464364410.2144/0001127981:CAS:528:DC%2BD1cXltlWqsrw%3D646, 648
ShanerNCSteinbachPATsienRYNat Methods2005290590910.1038/nmeth8191:CAS:528:DC%2BD2MXht1aksr3F
DongJSolntsevKMTolbertLMJ Am Chem Soc2006128120381203910.1021/ja063128a1:CAS:528:DC%2BD28XosFarsbs%3D
WachterRMElsligerMAKallioKHansonGTRemingtonSJStructure199861267127710.1016/S0969-2126(98)00127-01:CAS:528:DyaK1cXnt1Ogurk%3D
PrasherDCEckenrodeVKWardWWPrendergastFGCormierMJGene199211122923310.1016/0378-1119(92)90691-H1:CAS:528:DyaK3sXitVOktLw%3D
DigmanMADalalRHorwitzAFGrattonEBiophys J2008942320233210.1529/biophysj.107.1146451:CAS:528:DC%2BD1cXjtlKjsrw%3D
WachterRMYarbroughDKallioKRemingtonSJJ Mol Biol200030115717110.1006/jmbi.2000.39051:CAS:528:DC%2BD3cXltlequ7Y%3D
CharierSMeglioAAlcorDCogne-LaageEAllemandJFJullienLLemarchandAJ Am Chem Soc2005127154911550510.1021/ja053909w1:CAS:528:DC%2BD2MXhtFWku7jF
ZipfelWRWilliamsRMWebbWWNat Biotechnol2003211369137710.1038/nbt8991:CAS:528:DC%2BD3sXosFOksbk%3D
FliegelLInt J Biochem Cell Biol200537333710.1016/j.biocel.2004.02.0061:CAS:528:DC%2BD2cXnslKgs78%3D
SrivastavaJBarberDLJacobsonMPPhysiology (Bethesda)20072230391:CAS:528:DC%2BD2sXjtlaju74%3D
RinkTJTsienRYPozzanTJ Cell Biol19829518919610.1083/jcb.95.1.1891:CAS:528:DyaL38Xlsl2nt7s%3D
LukyanovKAChudakovDMFradkovAFLabasYAMatzMVLukyanovSMethods Biochem Anal20064712113810.1002/0471739499.ch6
UrraJSandovalMCornejoIBarrosLFSepúlvedaFVCidLPPflugers Arch200845723324210.1007/s00424-008-0497-21:CAS:528:DC%2BD1cXhtFCiurnN
SunHYWangNPHalkosMEKerendiFKinHWangRXGuytonRAZhaoZQEur J Pharmacol200448612113110.1016/j.ejphar.2003.12.0161:CAS:528:DC%2BD2cXht1yqtbk%3D
PattersonGDayRNPistonDJ Cell Sci20011148378381:STN:280:DC%2BD3M3lvVWksQ%3D%3D
SankaranarayananSDe AngelisDRothmanJERyanTABiophys J2000792199220810.1016/S0006-3495(00)76468-X1:CAS:528:DC%2BD3cXnt12htbs%3D
LlopisJMcCafferyJMMiyawakiAFarquharMGTsienRYProc Natl Acad Sci USA1998956803680810.1073/pnas.95.12.68031:CAS:528:DyaK1cXjslynur0%3D
ShuXKallioKShiXAbbyadPKanchanawongPChildsWBoxerSGRemingtonSJBiochemistry200746120051201310.1021/bi70090371:CAS:528:DC%2BD2sXhtFaqsLzM
DenkerSPBarberDLJ Cell Biol20021591087109610.1083/jcb.2002080501:CAS:528:DC%2BD3sXjt1em
MellmanIWarrenGCell20001009911210.1016/S0092-8674(00)81687-61:CAS:528:DC%2BD3cXks1CrsQ%3D%3D
WiehlerJJungGSeebacherCZumbuschASteipeBChembiochem200341164117110.1002/cbic.2003005951:CAS:528:DC%2BD3sXptFajtr0%3D
ChalfieMTuYEuskirchenGWardWWPrasherDCScience199426380280510.1126/science.83032951:CAS:528:DyaK2cXitFWkurc%3D
MiesenbockGDe AngelisDARothmanJENature199839419219510.1038/281901:CAS:528:DyaK1cXksFylsro%3D
LakowiczJRPrinciples of fluorescence spectroscopy1999OaklandPlenum
SonnleitnerASchutzGJSchmidtTBiophys J1999772638264210.1016/S0006-3495(99)77097-91:CAS:528:DyaK1MXnt1Wktbc%3D
UllmannGMJ Phys Chem B20031071263127110.1021/jp026454v1:CAS:528:DC%2BD3sXivF2qtg%3D%3D
WangHSinghDFliegelLJ Biol Chem1997272265452654910.1074/jbc.272.42.265451:CAS:528:DyaK2sXmvV2isbY%3D
Stoner-MaDJayeAARonayneKLNappaJMeechSRTongePJJ Am Chem Soc20081301227123510.1021/ja07545071:CAS:528:DC%2BD1cXivF2mug%3D%3D
ShuXLeidermanPGepshteinRSmithNRKallioKHuppertDRemingtonSJProtein Sci2007162703271010.1110/ps.0731120071:CAS:528:DC%2BD2sXhsVahsbrE
PuriSBachertCFimmelCJLinstedtADTraffic2002364165310.1034/j.1600-0854.2002.30906.x1:CAS:528:DC%2BD38XmslSrs74%3D
WachterRMAcc Chem Res20074012012710.1021/ar040086r1:CAS:528:DC%2BD28XhtF2ntLfJ
DiasproABianchiniPVicidominiGFarettaMRamoinoPUsaiCBiomed Eng online200653610.1186/1475-925X-5-36
BrejcKSixmaTKKittsPAKainSRTsienRYOrmoMRemingtonSJProc Natl Acad Sci USA1997942306231110.1073/pnas.94.6.23061:CAS:528:DyaK2sXhvF2lur4%3D
ChanFKSiegelRMZachariasDSwoffordRHolmesKLTsienRYLenardoMJCytometry20014436136810.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-31:CAS:528:DC%2BD3MXmsFOgsLg%3D
RybakSLLanniFMurphyRFBiophys J19977367468710.1016/S0006-3495(97)78102-51:CAS:528:DyaK2sXkvFCmur0%3D
LinHJHermanPLakowiczJRCytometry Part A200352A778910.1002/cyto.a.10028
ShimomuraOJohnsonFHSaigaYJ Cell Comp Physiol19625922323910.1002/jcp.10305903021:CAS:528:DyaF38XksFSrt7k%3D
ElsligerMAWachterRMHansonGTKallioKRemingtonSJBiochemistry1999385296530110.1021/bi99021821:CAS:528:DyaK1MXit12hs7o%3D
GriesbeckOBairdGSCampbellREZachariasDATsienRYJ Biol Chem2001276291882919410.1074/jbc.M1028152001:CAS:528:DC%2BD3MXlvFSqtr8%3D
MiyawakiANeuron20054818919910.1016/j.neuron.2005.10.0031:CAS:528:DC%2BD2MXhtF2itbfI
JahnRLangTSudhofTCCell200311251953310.1016/S0092-8674(03)00112-01:CAS:528:DC%2BD3sXhs1SnsLY%3D
HeikalAHessSWebbWWChem Phys2001274375510.1016/S0301-0104(01)00486-41:CAS:528:DC%2BD3MXoslOgt7Y%3D
WidengrenJTerryBRiglerRChem Phys199924925927110.1016/S0301-0104(99)00256-61:CAS:528:DC%2BD3cXhtFSrtQ%3D%3D
MarkovaOMukhtarovMRealEJacobYBregestovskiPJ Neurosci Methods2008170677610.1016/j.jneumeth.2007.12.0161:CAS:528:DC%2BD1cXktFCrsrY%3D
BonsmaSPurchaseRJezowskiSGallusJKonzFVolkerSChemphyschem2005683884910.1002/cphc.2005000051:CAS:528:DC%2BD2MXksFWqu70%3D
PutneyLKBarberDLJ Biol Chem2003278446454464910.1074/jbc.M3080992001:CAS:528:DC%2BD3sXoslWls78%3D
TsienRYAnnu Rev Biochem19986750954410.1146/annurev.biochem.67.1.5091:CAS:528:DyaK1cXlsFOmsb8%3D
ChattorajMKingBABublitzGUBoxerSGProc Natl Acad Sci USA1996938362836710.1073/pnas.93.16.83621:CAS:528:DyaK28XkvFylu7k%3D
DubbinPNCodySHWilliamsDAMicron19932458158610.1016/0968-4328(93)90035-Y
ZhangLPatelHNLappeJWWachterRMJ Am Chem Soc20061284766477210.1021/ja05804391:CAS:528:DC%2BD28XitlOitLY%3D
AlbotaMAXuCWebbWWAppl Opt1998377352735610.1364/AO.37.0073521:CAS:528:DyaK1cXntlSitLY%3D
ZhangJCampbellRETingAYTsienRYNat Rev Mol Cell Biol2002390691810.1038/nrm9761:CAS:528:DC%2BD38XptFKnt7Y%3D
ChiricoGCannoneFDiasproABolognaSPellegriniVNifosiRBeltramFPhys Rev E20047003090110.1103/PhysRevE.70.0309011:CAS:528:DC%2BD2cXotleqtro%3D
VoityukAAMichel-BeyerleMERoschNChem Phys1998231132510.1016/S0301-0104(98)00080-91:CAS:528:DyaK1cXjtVamsLk%3D
KaragiannisJYoungPGJ Cell Sci2001114292929411:CAS:528:DC%2BD3MXmvFCqsLw%3D
HauptsUMaitiSSchwillePWebbWWProc Natl Acad Sci USA199895135731357810.1073/pnas.95.23.135731:CAS:528:DyaK1cXnsVGgs7o%3D
KapusASzasziKSunJRizoliSRotsteinODJ Biol Chem19992748093810210.1074/jbc.274.12.80931:CAS:528:DyaK1MXitFSrsrs%3D
MarcelloALusicMPegoraroGPellegriniVBeltramFGiaccaMGene200432611110.1016/j.gene.2003.10.0181:CAS:528:DC%2BD2cXit1KlsA%3D%3D
TsienRYMethods Cell Biol19893012715610.1016/S0091-679X(08)60978-41:CAS:528:DyaL1MXkvFejsLc%3D
ChanatEHuttnerWBJ Cell Biol19911151505151910.1083/jcb.115.6.15051:CAS:528:DyaK38XltFyqug%3D%3D
HunteCScrepantiEVenturiMRimonAPadanEMichelHNature20054351197120210.1038/nature036921:CAS:528:DC%2BD2MXls1OntbY%3D
Serresi M, Bizzarri R, Cardarelli F, Beltram F (2009) Anal Bioanal Chem. doi:10.1007/s00216-008-2489-7
SniegowskiJALappeJWPatelHNHuffmanHAWachterRMJ Biol Chem2005280262482625510.1074/jbc.M4123272001:CAS:528:DC%2BD2MXlvFymtL0%3D
WlodarczykJWoehlerAKobeFPonimaskinEZeugANeherEBiophys J200894986100010.1529/biophysj.107.1117731:CAS:528:DC%2BD1cXhsVahsb4%3D
BosisioCQuercioliVColliniMD’AlfonsoLBaldiniGBettatiSCampaniniBRaboniSChiricoGJ Phys Chem B20081128806881410.1021/jp801164n1:CAS:528:DC%2BD1cXnvVKlu7o%3D
HessSTHeikalAAWebbWWJ Phys Chem B2004108101381014810.1021/jp03620771:CAS:528:DC%2BD2cXjt12rsr8%3D
AbadMFCDi BenedettoGMagalhaesPJFilippinLPozzanTJ Biol Chem2004279115211152910.1074/jbc.M3067662001:CAS:528:DC%2BD2cXitFyhtL8%3D
CardarelliFSerresiMBizzarriRGiaccaMBeltramFMolec Ther2007151313132210.1038/sj.mt.63001721:CAS:528:DC%2BD2sXhtVejtLrP
Tsien RY (2003) Nat Rev Mol Cell Biol Suppl S16–21
ChiricoGDiasproACannoneFColliniMBolognaSPellegriniVBeltramFChemphyschem2005632833510.1002/cphc.2004003181:CAS:528:DC%2BD2MXhvVejtbk%3D
HellSWNat Biotechnol2003211347135510.1038/nbt8951:CAS:528:DC%2BD3sXosFOksb0%3D
ChudakovDMLukyanovSLukyanovKATrends Biotechnol20052360561310.1016/j.tibtech.2005.10.0051:CAS:528:DC%2BD2MXht1Omu7vE
SvobodaKYasudaRNeuron20065082383910.1016/j.neuron.2006.05.0191:CAS:528:DC%2BD28XmsVOjsrg%3D
AwajiTHirasawaAShirakawaHTsujimotoGMiyazakiSBiochem Biophys Res Commun200128945746210.1006/bbrc.2001.60041:CAS:528:DC%2BD3MXosFGiur4%3D
GrynkiewiczGPoenieMTsienRYJ Biol Chem1985260344034501:CAS:528:DyaL2MXitVSmu7s%3D
AbbruzzettiSGrandiEViappianiCBolognaSCampaniniBRaboniSBettatiSMozzarelliAJ Am Chem Soc200512762663510.1021/ja045400r1:CAS:528:DC%2BD2cXhtVCrurrL
ArosioDGarauGRicciFMarchettiLBizzarriRNifosiRBeltramFBiophys J20079323224410.1529/biophysj.106.1023191:CAS:528:DC%2BD2sXntVKqtbY%3D
CreemersTMLockAJSubramaniamVJovinTMVolkerSNat Struct Biol1999655756010.1038/107631:CAS:528:DyaK1MXksVemsr4%3D
DigmanMABrownCMSenguptaPWisemanPWHorwitzARGrattonEBiophys J2005891317132710.1529/biophysj.105.0628361:CAS:528:DC%2BD2MXnvVSrsb0%3D
OrmoMCubittABKallioKGrossLATsienRYRemingtonSJScience19962731392139510.1126/science.273.5280.13921:CAS:528:DyaK28XlsVCnu7s%3D
WardWWBokmanSHBiochemistry1982214535454010.1021/bi00262a0031:CAS:528:DyaL38XltVGkt7k%3D
BizzarriRArcangeliCArosioDRicciFFaraciPCardarelliFBeltramFBiophys J2006903300331410.1529/biophysj.105.0747081:CAS:528:DC%2BD28XktVKrt7g%3D
JankowskiAKimJHCollinsRFDanemanRWaltonPGrinsteinSJ Biol Chem2001276487484875310.1074/jbc.M1090032001:CAS:528:DC%2BD38Xktlejtg%3D%3D
CarnellLMooreHPJ Cell Biol199412769370510.1083/jcb.127.3.6931:CAS:528:DyaK2cXmsVOitLc%3D
McAnaneyTBParkESHansonGTRemingtonSJBoxerSGBiochemistry200241154891549410.1021/bi026610o1:CAS:528:DC%2BD38Xpt1yntrg%3D
MachenTELeighMJTaylorCKimuraTAsanoSMooreHPAm J Physiol2003285C2052141:CAS:528:DC%2BD3sXls1Wntb0%3D
WakabayashiIPoteserMGroschnerKJ Vasc Res20064323825010.1159/000091235
KennisJTLarsenDSvan StokkumIHVengrisMvan ThorJJvan GrondelleRProc Natl Acad Sci USA2004101179881799310.1073/pnas.04042621021:CAS:528:DC%2BD2MXjsl2gtA%3D%3D
CodySHDubbinPNBeischerADDuncanNDHillJSKayeAHWilliamsDAMicron19932457358010.1016/0968-4328(93)90034-X
WebberNMLitvinenkoKLMeechSRJ Phys Chem B20011058036803910.1021/jp011430u1:CAS:528:DC%2BD3MXltlygsLg%3D
NiwaHInouyeSHiranoTMatsunoTKojimaSKubotaMOhashiMT
A Diaspro (2515_CR94) 2006; 5
A Marcello (2515_CR84) 2004; 326
M Chalfie (2515_CR25) 1994; 263
T Awaji (2515_CR87) 2001; 289
DC Prasher (2515_CR24) 1992; 111
HJ Lin (2515_CR21) 2003; 52A
K Brejc (2515_CR35) 1997; 94
A Jankowski (2515_CR76) 2001; 276
M Kneen (2515_CR53) 1998; 74
G Miesenbock (2515_CR69) 1998; 394
G Patterson (2515_CR72) 2001; 114
KA Lukyanov (2515_CR52) 2006; 47
G Grynkiewicz (2515_CR57) 1985; 260
H Wang (2515_CR2) 1997; 272
TM Creemers (2515_CR49) 1999; 6
WR Zipfel (2515_CR96) 2003; 21
JR Lakowicz (2515_CR18) 1999
J Llopis (2515_CR44) 1998; 95
SP Denker (2515_CR8) 2002; 159
J Wlodarczyk (2515_CR89) 2008; 94
RY Tsien (2515_CR23) 1998; 67
MFC Abad (2515_CR13) 2004; 279
A Schulte (2515_CR78) 2006; 2
A Heikal (2515_CR101) 2001; 274
GM Ullmann (2515_CR56) 2003; 107
AA Voityuk (2515_CR45) 1998; 231
L Carnell (2515_CR14) 1994; 127
NM Webber (2515_CR33) 2001; 105
F Cardarelli (2515_CR60) 2008; 9
O Markova (2515_CR91) 2008; 170
FK Chan (2515_CR88) 2001; 44
TB McAnaney (2515_CR47) 2002; 41
PN Dubbin (2515_CR82) 1993; 24
J Wiehler (2515_CR50) 2003; 4
RM Wachter (2515_CR31) 2007; 40
D Stoner-Ma (2515_CR102) 2008; 130
AF Bell (2515_CR40) 2000; 39
X Shu (2515_CR80) 2007; 46
C Bosisio (2515_CR64) 2008; 112
H Niwa (2515_CR32) 1996; 93
ST Hess (2515_CR70) 2004; 108
G Chirico (2515_CR98) 2005; 6
G Chirico (2515_CR99) 2004; 70
F Cardarelli (2515_CR61) 2007; 15
O Shimomura (2515_CR22) 1962; 59
MA Elsliger (2515_CR42) 1999; 38
R Jahn (2515_CR12) 2003; 112
K Svoboda (2515_CR97) 2006; 50
SH Cody (2515_CR81) 1993; 24
SL Rybak (2515_CR11) 1997; 73
R Bizzarri (2515_CR43) 2007; 46
I Mellman (2515_CR10) 2000; 100
DM Chudakov (2515_CR26) 2005; 23
AD Kummer (2515_CR36) 2000; 104
RM Wachter (2515_CR37) 2000; 301
S Puri (2515_CR16) 2002; 3
C Hunte (2515_CR5) 2005; 435
MA Digman (2515_CR95) 2008; 94
D Arosio (2515_CR85) 2007; 93
M Ormo (2515_CR30) 1996; 273
TJ Rink (2515_CR19) 1982; 95
S Charier (2515_CR66) 2005; 127
J Karagiannis (2515_CR75) 2001; 114
J Zhang (2515_CR29) 2002; 3
2515_CR86
J Widengren (2515_CR65) 1999; 249
SW Hell (2515_CR62) 2003; 21
S Jayaraman (2515_CR73) 2000; 275
X Shu (2515_CR79) 2007; 16
HY Sun (2515_CR7) 2004; 486
A Kapus (2515_CR9) 1999; 274
A Sonnleitner (2515_CR58) 1999; 77
J Urra (2515_CR90) 2008; 457
LK Putney (2515_CR3) 2003; 278
S Kellokumpu (2515_CR17) 2002; 516
NC Shaner (2515_CR28) 2005; 2
JT Kennis (2515_CR51) 2004; 101
R Bizzarri (2515_CR83) 2006; 90
MA Albota (2515_CR100) 1998; 37
I Wakabayashi (2515_CR6) 2006; 43
2515_CR92
TE Machen (2515_CR77) 2003; 285
M Chattoraj (2515_CR46) 1996; 93
MA Digman (2515_CR59) 2005; 89
L Fliegel (2515_CR4) 2005; 37
J Srivastava (2515_CR1) 2007; 22
RM Wachter (2515_CR71) 1998; 6
E Chanat (2515_CR15) 1991; 115
RY Tsien (2515_CR20) 1989; 30
S Abbruzzetti (2515_CR54) 2005; 127
WW Ward (2515_CR34) 1982; 21
U Haupts (2515_CR63) 1998; 95
S Bonsma (2515_CR48) 2005; 6
JA Sniegowski (2515_CR38) 2005; 280
GT Hanson (2515_CR55) 2002; 41
A Miyawaki (2515_CR27) 2005; 48
T Nakabayashi (2515_CR68) 2008; 7
L Zhang (2515_CR39) 2006; 128
S Sankaranarayanan (2515_CR67) 2000; 79
O Griesbeck (2515_CR74) 2001; 276
S Paddock (2515_CR93) 2008; 44
J Dong (2515_CR41) 2006; 128
References_xml – reference: ElsligerMAWachterRMHansonGTKallioKRemingtonSJBiochemistry1999385296530110.1021/bi99021821:CAS:528:DyaK1MXit12hs7o%3D
– reference: PattersonGDayRNPistonDJ Cell Sci20011148378381:STN:280:DC%2BD3M3lvVWksQ%3D%3D
– reference: ChanFKSiegelRMZachariasDSwoffordRHolmesKLTsienRYLenardoMJCytometry20014436136810.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-31:CAS:528:DC%2BD3MXmsFOgsLg%3D
– reference: RinkTJTsienRYPozzanTJ Cell Biol19829518919610.1083/jcb.95.1.1891:CAS:528:DyaL38Xlsl2nt7s%3D
– reference: AbbruzzettiSGrandiEViappianiCBolognaSCampaniniBRaboniSBettatiSMozzarelliAJ Am Chem Soc200512762663510.1021/ja045400r1:CAS:528:DC%2BD2cXhtVCrurrL
– reference: HellSWNat Biotechnol2003211347135510.1038/nbt8951:CAS:528:DC%2BD3sXosFOksb0%3D
– reference: McAnaneyTBParkESHansonGTRemingtonSJBoxerSGBiochemistry200241154891549410.1021/bi026610o1:CAS:528:DC%2BD38Xpt1yntrg%3D
– reference: BonsmaSPurchaseRJezowskiSGallusJKonzFVolkerSChemphyschem2005683884910.1002/cphc.2005000051:CAS:528:DC%2BD2MXksFWqu70%3D
– reference: ChattorajMKingBABublitzGUBoxerSGProc Natl Acad Sci USA1996938362836710.1073/pnas.93.16.83621:CAS:528:DyaK28XkvFylu7k%3D
– reference: KellokumpuSSormunenRKellokumpuIFEBS Lett200251621722410.1016/S0014-5793(02)02535-81:CAS:528:DC%2BD38XivVaitbw%3D
– reference: DigmanMABrownCMSenguptaPWisemanPWHorwitzARGrattonEBiophys J2005891317132710.1529/biophysj.105.0628361:CAS:528:DC%2BD2MXnvVSrsb0%3D
– reference: PuriSBachertCFimmelCJLinstedtADTraffic2002364165310.1034/j.1600-0854.2002.30906.x1:CAS:528:DC%2BD38XmslSrs74%3D
– reference: CharierSMeglioAAlcorDCogne-LaageEAllemandJFJullienLLemarchandAJ Am Chem Soc2005127154911550510.1021/ja053909w1:CAS:528:DC%2BD2MXhtFWku7jF
– reference: WidengrenJTerryBRiglerRChem Phys199924925927110.1016/S0301-0104(99)00256-61:CAS:528:DC%2BD3cXhtFSrtQ%3D%3D
– reference: PutneyLKBarberDLJ Biol Chem2003278446454464910.1074/jbc.M3080992001:CAS:528:DC%2BD3sXoslWls78%3D
– reference: ZhangJCampbellRETingAYTsienRYNat Rev Mol Cell Biol2002390691810.1038/nrm9761:CAS:528:DC%2BD38XptFKnt7Y%3D
– reference: DenkerSPBarberDLJ Cell Biol20021591087109610.1083/jcb.2002080501:CAS:528:DC%2BD3sXjt1em
– reference: ChudakovDMLukyanovSLukyanovKATrends Biotechnol20052360561310.1016/j.tibtech.2005.10.0051:CAS:528:DC%2BD2MXht1Omu7vE
– reference: WlodarczykJWoehlerAKobeFPonimaskinEZeugANeherEBiophys J200894986100010.1529/biophysj.107.1117731:CAS:528:DC%2BD1cXhsVahsb4%3D
– reference: ZhangLPatelHNLappeJWWachterRMJ Am Chem Soc20061284766477210.1021/ja05804391:CAS:528:DC%2BD28XitlOitLY%3D
– reference: WardWWBokmanSHBiochemistry1982214535454010.1021/bi00262a0031:CAS:528:DyaL38XltVGkt7k%3D
– reference: HessSTHeikalAAWebbWWJ Phys Chem B2004108101381014810.1021/jp03620771:CAS:528:DC%2BD2cXjt12rsr8%3D
– reference: CarnellLMooreHPJ Cell Biol199412769370510.1083/jcb.127.3.6931:CAS:528:DyaK2cXmsVOitLc%3D
– reference: DongJSolntsevKMTolbertLMJ Am Chem Soc2006128120381203910.1021/ja063128a1:CAS:528:DC%2BD28XosFarsbs%3D
– reference: HauptsUMaitiSSchwillePWebbWWProc Natl Acad Sci USA199895135731357810.1073/pnas.95.23.135731:CAS:528:DyaK1cXnsVGgs7o%3D
– reference: WebberNMLitvinenkoKLMeechSRJ Phys Chem B20011058036803910.1021/jp011430u1:CAS:528:DC%2BD3MXltlygsLg%3D
– reference: KneenMFarinasJLiYVerkmanASBiophys J1998741591159910.1016/S0006-3495(98)77870-11:CAS:528:DyaK1cXis1amtbw%3D
– reference: DubbinPNCodySHWilliamsDAMicron19932458158610.1016/0968-4328(93)90035-Y
– reference: BizzarriRArcangeliCArosioDRicciFFaraciPCardarelliFBeltramFBiophys J2006903300331410.1529/biophysj.105.0747081:CAS:528:DC%2BD28XktVKrt7g%3D
– reference: WiehlerJJungGSeebacherCZumbuschASteipeBChembiochem200341164117110.1002/cbic.2003005951:CAS:528:DC%2BD3sXptFajtr0%3D
– reference: GrynkiewiczGPoenieMTsienRYJ Biol Chem1985260344034501:CAS:528:DyaL2MXitVSmu7s%3D
– reference: KapusASzasziKSunJRizoliSRotsteinODJ Biol Chem19992748093810210.1074/jbc.274.12.80931:CAS:528:DyaK1MXitFSrsrs%3D
– reference: CreemersTMLockAJSubramaniamVJovinTMVolkerSNat Struct Biol1999655756010.1038/107631:CAS:528:DyaK1MXksVemsr4%3D
– reference: LukyanovKAChudakovDMFradkovAFLabasYAMatzMVLukyanovSMethods Biochem Anal20064712113810.1002/0471739499.ch6
– reference: CodySHDubbinPNBeischerADDuncanNDHillJSKayeAHWilliamsDAMicron19932457358010.1016/0968-4328(93)90034-X
– reference: MachenTELeighMJTaylorCKimuraTAsanoSMooreHPAm J Physiol2003285C2052141:CAS:528:DC%2BD3sXls1Wntb0%3D
– reference: WangHSinghDFliegelLJ Biol Chem1997272265452654910.1074/jbc.272.42.265451:CAS:528:DyaK2sXmvV2isbY%3D
– reference: PrasherDCEckenrodeVKWardWWPrendergastFGCormierMJGene199211122923310.1016/0378-1119(92)90691-H1:CAS:528:DyaK3sXitVOktLw%3D
– reference: LakowiczJRPrinciples of fluorescence spectroscopy1999OaklandPlenum
– reference: ChalfieMTuYEuskirchenGWardWWPrasherDCScience199426380280510.1126/science.83032951:CAS:528:DyaK2cXitFWkurc%3D
– reference: KaragiannisJYoungPGJ Cell Sci2001114292929411:CAS:528:DC%2BD3MXmvFCqsLw%3D
– reference: HunteCScrepantiEVenturiMRimonAPadanEMichelHNature20054351197120210.1038/nature036921:CAS:528:DC%2BD2MXls1OntbY%3D
– reference: KummerADWiehlerJRehaberHKompaCSteipeBMichel-BeyerleMEJ Phys Chem B20001044791479810.1021/jp99425221:CAS:528:DC%2BD3cXis1Wgsrc%3D
– reference: OrmoMCubittABKallioKGrossLATsienRYRemingtonSJScience19962731392139510.1126/science.273.5280.13921:CAS:528:DyaK28XlsVCnu7s%3D
– reference: ArosioDGarauGRicciFMarchettiLBizzarriRNifosiRBeltramFBiophys J20079323224410.1529/biophysj.106.1023191:CAS:528:DC%2BD2sXntVKqtbY%3D
– reference: BizzarriRNifosiRAbbruzzettiSRocchiaWGuidiSArosioDGarauGCampaniniBGrandiERicciFViappianiCBeltramFBiochemistry2007465494550410.1021/bi602646r1:CAS:528:DC%2BD2sXkt1elsrs%3D
– reference: SonnleitnerASchutzGJSchmidtTBiophys J1999772638264210.1016/S0006-3495(99)77097-91:CAS:528:DyaK1MXnt1Wktbc%3D
– reference: ShanerNCSteinbachPATsienRYNat Methods2005290590910.1038/nmeth8191:CAS:528:DC%2BD2MXht1aksr3F
– reference: MiyawakiANeuron20054818919910.1016/j.neuron.2005.10.0031:CAS:528:DC%2BD2MXhtF2itbfI
– reference: AlbotaMAXuCWebbWWAppl Opt1998377352735610.1364/AO.37.0073521:CAS:528:DyaK1cXntlSitLY%3D
– reference: WakabayashiIPoteserMGroschnerKJ Vasc Res20064323825010.1159/000091235
– reference: MarkovaOMukhtarovMRealEJacobYBregestovskiPJ Neurosci Methods2008170677610.1016/j.jneumeth.2007.12.0161:CAS:528:DC%2BD1cXktFCrsrY%3D
– reference: WachterRMAcc Chem Res20074012012710.1021/ar040086r1:CAS:528:DC%2BD28XhtF2ntLfJ
– reference: TsienRYMethods Cell Biol19893012715610.1016/S0091-679X(08)60978-41:CAS:528:DyaL1MXkvFejsLc%3D
– reference: Tsien RY (2003) Nat Rev Mol Cell Biol Suppl S16–21
– reference: HeikalAHessSWebbWWChem Phys2001274375510.1016/S0301-0104(01)00486-41:CAS:528:DC%2BD3MXoslOgt7Y%3D
– reference: GriesbeckOBairdGSCampbellREZachariasDATsienRYJ Biol Chem2001276291882919410.1074/jbc.M1028152001:CAS:528:DC%2BD3MXlvFSqtr8%3D
– reference: ChiricoGDiasproACannoneFColliniMBolognaSPellegriniVBeltramFChemphyschem2005632833510.1002/cphc.2004003181:CAS:528:DC%2BD2MXhvVejtbk%3D
– reference: BrejcKSixmaTKKittsPAKainSRTsienRYOrmoMRemingtonSJProc Natl Acad Sci USA1997942306231110.1073/pnas.94.6.23061:CAS:528:DyaK2sXhvF2lur4%3D
– reference: FliegelLInt J Biochem Cell Biol200537333710.1016/j.biocel.2004.02.0061:CAS:528:DC%2BD2cXnslKgs78%3D
– reference: ShuXLeidermanPGepshteinRSmithNRKallioKHuppertDRemingtonSJProtein Sci2007162703271010.1110/ps.0731120071:CAS:528:DC%2BD2sXhsVahsbrE
– reference: UllmannGMJ Phys Chem B20031071263127110.1021/jp026454v1:CAS:528:DC%2BD3sXivF2qtg%3D%3D
– reference: AwajiTHirasawaAShirakawaHTsujimotoGMiyazakiSBiochem Biophys Res Commun200128945746210.1006/bbrc.2001.60041:CAS:528:DC%2BD3MXosFGiur4%3D
– reference: PaddockSBiotechniques20084464364410.2144/0001127981:CAS:528:DC%2BD1cXltlWqsrw%3D646, 648
– reference: NiwaHInouyeSHiranoTMatsunoTKojimaSKubotaMOhashiMTsujiFIProc Natl Acad Sci USA199693136171362210.1073/pnas.93.24.136171:CAS:528:DyaK28Xnt1Ghtbo%3D
– reference: ShimomuraOJohnsonFHSaigaYJ Cell Comp Physiol19625922323910.1002/jcp.10305903021:CAS:528:DyaF38XksFSrt7k%3D
– reference: BosisioCQuercioliVColliniMD’AlfonsoLBaldiniGBettatiSCampaniniBRaboniSChiricoGJ Phys Chem B20081128806881410.1021/jp801164n1:CAS:528:DC%2BD1cXnvVKlu7o%3D
– reference: SankaranarayananSDe AngelisDRothmanJERyanTABiophys J2000792199220810.1016/S0006-3495(00)76468-X1:CAS:528:DC%2BD3cXnt12htbs%3D
– reference: BellAFHeXWachterRMTongePJBiochemistry2000394423443110.1021/bi992675o1:CAS:528:DC%2BD3cXhvVykt70%3D
– reference: MiesenbockGDe AngelisDARothmanJENature199839419219510.1038/281901:CAS:528:DyaK1cXksFylsro%3D
– reference: MellmanIWarrenGCell20001009911210.1016/S0092-8674(00)81687-61:CAS:528:DC%2BD3cXks1CrsQ%3D%3D
– reference: ChanatEHuttnerWBJ Cell Biol19911151505151910.1083/jcb.115.6.15051:CAS:528:DyaK38XltFyqug%3D%3D
– reference: JahnRLangTSudhofTCCell200311251953310.1016/S0092-8674(03)00112-01:CAS:528:DC%2BD3sXhs1SnsLY%3D
– reference: HansonGTMcAnaneyTBParkESRendellMEYarbroughDKChuSXiLBoxerSGMontroseMHRemingtonSJBiochemistry200241154771548810.1021/bi026609p1:CAS:528:DC%2BD38Xpt1yntrs%3D
– reference: LinHJHermanPLakowiczJRCytometry Part A200352A778910.1002/cyto.a.10028
– reference: ZipfelWRWilliamsRMWebbWWNat Biotechnol2003211369137710.1038/nbt8991:CAS:528:DC%2BD3sXosFOksbk%3D
– reference: UrraJSandovalMCornejoIBarrosLFSepúlvedaFVCidLPPflugers Arch200845723324210.1007/s00424-008-0497-21:CAS:528:DC%2BD1cXhtFCiurnN
– reference: Serresi M, Bizzarri R, Cardarelli F, Beltram F (2009) Anal Bioanal Chem. doi:10.1007/s00216-008-2489-7
– reference: JayaramanSHaggiePWachterRMRemingtonSJVerkmanASJ Biol Chem20002756047605010.1074/jbc.275.9.60471:CAS:528:DC%2BD3cXhslWrsrs%3D
– reference: LlopisJMcCafferyJMMiyawakiAFarquharMGTsienRYProc Natl Acad Sci USA1998956803680810.1073/pnas.95.12.68031:CAS:528:DyaK1cXjslynur0%3D
– reference: CardarelliFSerresiMBizzarriRGiaccaMBeltramFMolec Ther2007151313132210.1038/sj.mt.63001721:CAS:528:DC%2BD2sXhtVejtLrP
– reference: NakabayashiTWangHPKinjoMOhtaNPhotochem Photobiol Sci2008766867010.1039/b800391b1:CAS:528:DC%2BD1cXms1CjtLc%3D
– reference: DigmanMADalalRHorwitzAFGrattonEBiophys J2008942320233210.1529/biophysj.107.1146451:CAS:528:DC%2BD1cXjtlKjsrw%3D
– reference: Stoner-MaDJayeAARonayneKLNappaJMeechSRTongePJJ Am Chem Soc20081301227123510.1021/ja07545071:CAS:528:DC%2BD1cXivF2mug%3D%3D
– reference: TsienRYAnnu Rev Biochem19986750954410.1146/annurev.biochem.67.1.5091:CAS:528:DyaK1cXlsFOmsb8%3D
– reference: RybakSLLanniFMurphyRFBiophys J19977367468710.1016/S0006-3495(97)78102-51:CAS:528:DyaK2sXkvFCmur0%3D
– reference: KennisJTLarsenDSvan StokkumIHVengrisMvan ThorJJvan GrondelleRProc Natl Acad Sci USA2004101179881799310.1073/pnas.04042621021:CAS:528:DC%2BD2MXjsl2gtA%3D%3D
– reference: SunHYWangNPHalkosMEKerendiFKinHWangRXGuytonRAZhaoZQEur J Pharmacol200448612113110.1016/j.ejphar.2003.12.0161:CAS:528:DC%2BD2cXht1yqtbk%3D
– reference: VoityukAAMichel-BeyerleMERoschNChem Phys1998231132510.1016/S0301-0104(98)00080-91:CAS:528:DyaK1cXjtVamsLk%3D
– reference: ShuXKallioKShiXAbbyadPKanchanawongPChildsWBoxerSGRemingtonSJBiochemistry200746120051201310.1021/bi70090371:CAS:528:DC%2BD2sXhtFaqsLzM
– reference: WachterRMElsligerMAKallioKHansonGTRemingtonSJStructure199861267127710.1016/S0969-2126(98)00127-01:CAS:528:DyaK1cXnt1Ogurk%3D
– reference: SniegowskiJALappeJWPatelHNHuffmanHAWachterRMJ Biol Chem2005280262482625510.1074/jbc.M4123272001:CAS:528:DC%2BD2MXlvFymtL0%3D
– reference: MarcelloALusicMPegoraroGPellegriniVBeltramFGiaccaMGene200432611110.1016/j.gene.2003.10.0181:CAS:528:DC%2BD2cXit1KlsA%3D%3D
– reference: WachterRMYarbroughDKallioKRemingtonSJJ Mol Biol200030115717110.1006/jmbi.2000.39051:CAS:528:DC%2BD3cXltlequ7Y%3D
– reference: AbadMFCDi BenedettoGMagalhaesPJFilippinLPozzanTJ Biol Chem2004279115211152910.1074/jbc.M3067662001:CAS:528:DC%2BD2cXitFyhtL8%3D
– reference: CardarelliFSerresiMBizzarriRBeltramFTraffic2008952853910.1111/j.1600-0854.2007.00696.x1:CAS:528:DC%2BD1cXkt1ais7Y%3D
– reference: DiasproABianchiniPVicidominiGFarettaMRamoinoPUsaiCBiomed Eng online200653610.1186/1475-925X-5-36
– reference: JankowskiAKimJHCollinsRFDanemanRWaltonPGrinsteinSJ Biol Chem2001276487484875310.1074/jbc.M1090032001:CAS:528:DC%2BD38Xktlejtg%3D%3D
– reference: SchulteALorenzenIBottcherMPliethCPlant Methods20062710.1186/1746-4811-2-71:CAS:528:DC%2BD28XktVCqs7s%3D
– reference: SrivastavaJBarberDLJacobsonMPPhysiology (Bethesda)20072230391:CAS:528:DC%2BD2sXjtlaju74%3D
– reference: ChiricoGCannoneFDiasproABolognaSPellegriniVNifosiRBeltramFPhys Rev E20047003090110.1103/PhysRevE.70.0309011:CAS:528:DC%2BD2cXotleqtro%3D
– reference: SvobodaKYasudaRNeuron20065082383910.1016/j.neuron.2006.05.0191:CAS:528:DC%2BD28XmsVOjsrg%3D
– volume: 59
  start-page: 223
  year: 1962
  ident: 2515_CR22
  publication-title: J Cell Comp Physiol
  doi: 10.1002/jcp.1030590302
– volume: 22
  start-page: 30
  year: 2007
  ident: 2515_CR1
  publication-title: Physiology (Bethesda)
  doi: 10.1152/physiol.00035.2006
– volume: 108
  start-page: 10138
  year: 2004
  ident: 2515_CR70
  publication-title: J Phys Chem B
  doi: 10.1021/jp0362077
– volume: 52A
  start-page: 77
  year: 2003
  ident: 2515_CR21
  publication-title: Cytometry Part A
  doi: 10.1002/cyto.a.10028
– volume: 44
  start-page: 361
  year: 2001
  ident: 2515_CR88
  publication-title: Cytometry
  doi: 10.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-3
– volume: 16
  start-page: 2703
  year: 2007
  ident: 2515_CR79
  publication-title: Protein Sci
  doi: 10.1110/ps.073112007
– volume: 112
  start-page: 8806
  year: 2008
  ident: 2515_CR64
  publication-title: J Phys Chem B
  doi: 10.1021/jp801164n
– volume: 486
  start-page: 121
  year: 2004
  ident: 2515_CR7
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2003.12.016
– volume: 6
  start-page: 838
  year: 2005
  ident: 2515_CR48
  publication-title: Chemphyschem
  doi: 10.1002/cphc.200500005
– volume: 21
  start-page: 1369
  year: 2003
  ident: 2515_CR96
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt899
– volume: 39
  start-page: 4423
  year: 2000
  ident: 2515_CR40
  publication-title: Biochemistry
  doi: 10.1021/bi992675o
– volume: 5
  start-page: 36
  year: 2006
  ident: 2515_CR94
  publication-title: Biomed Eng online
  doi: 10.1186/1475-925X-5-36
– volume: 289
  start-page: 457
  year: 2001
  ident: 2515_CR87
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.2001.6004
– volume: 260
  start-page: 3440
  year: 1985
  ident: 2515_CR57
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)83641-4
– volume: 79
  start-page: 2199
  year: 2000
  ident: 2515_CR67
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(00)76468-X
– volume-title: Principles of fluorescence spectroscopy
  year: 1999
  ident: 2515_CR18
  doi: 10.1007/978-1-4757-3061-6
– volume: 41
  start-page: 15477
  year: 2002
  ident: 2515_CR55
  publication-title: Biochemistry
  doi: 10.1021/bi026609p
– volume: 3
  start-page: 641
  year: 2002
  ident: 2515_CR16
  publication-title: Traffic
  doi: 10.1034/j.1600-0854.2002.30906.x
– volume: 127
  start-page: 693
  year: 1994
  ident: 2515_CR14
  publication-title: J Cell Biol
  doi: 10.1083/jcb.127.3.693
– volume: 273
  start-page: 1392
  year: 1996
  ident: 2515_CR30
  publication-title: Science
  doi: 10.1126/science.273.5280.1392
– volume: 394
  start-page: 192
  year: 1998
  ident: 2515_CR69
  publication-title: Nature
  doi: 10.1038/28190
– volume: 285
  start-page: C205
  year: 2003
  ident: 2515_CR77
  publication-title: Am J Physiol
  doi: 10.1152/ajpcell.00008.2003
– volume: 457
  start-page: 233
  year: 2008
  ident: 2515_CR90
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-008-0497-2
– volume: 21
  start-page: 4535
  year: 1982
  ident: 2515_CR34
  publication-title: Biochemistry
  doi: 10.1021/bi00262a003
– volume: 3
  start-page: 906
  year: 2002
  ident: 2515_CR29
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm976
– volume: 114
  start-page: 837
  year: 2001
  ident: 2515_CR72
  publication-title: J Cell Sci
  doi: 10.1242/jcs.114.5.837
– volume: 37
  start-page: 7352
  year: 1998
  ident: 2515_CR100
  publication-title: Appl Opt
  doi: 10.1364/AO.37.007352
– volume: 276
  start-page: 29188
  year: 2001
  ident: 2515_CR74
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M102815200
– volume: 272
  start-page: 26545
  year: 1997
  ident: 2515_CR2
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.42.26545
– volume: 276
  start-page: 48748
  year: 2001
  ident: 2515_CR76
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109003200
– volume: 105
  start-page: 8036
  year: 2001
  ident: 2515_CR33
  publication-title: J Phys Chem B
  doi: 10.1021/jp011430u
– volume: 90
  start-page: 3300
  year: 2006
  ident: 2515_CR83
  publication-title: Biophys J
  doi: 10.1529/biophysj.105.074708
– volume: 4
  start-page: 1164
  year: 2003
  ident: 2515_CR50
  publication-title: Chembiochem
  doi: 10.1002/cbic.200300595
– volume: 24
  start-page: 573
  year: 1993
  ident: 2515_CR81
  publication-title: Micron
  doi: 10.1016/0968-4328(93)90034-X
– volume: 95
  start-page: 189
  year: 1982
  ident: 2515_CR19
  publication-title: J Cell Biol
  doi: 10.1083/jcb.95.1.189
– volume: 95
  start-page: 13573
  year: 1998
  ident: 2515_CR63
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.23.13573
– volume: 38
  start-page: 5296
  year: 1999
  ident: 2515_CR42
  publication-title: Biochemistry
  doi: 10.1021/bi9902182
– volume: 249
  start-page: 259
  year: 1999
  ident: 2515_CR65
  publication-title: Chem Phys
  doi: 10.1016/S0301-0104(99)00256-6
– volume: 170
  start-page: 67
  year: 2008
  ident: 2515_CR91
  publication-title: J Neurosci Methods
  doi: 10.1016/j.jneumeth.2007.12.016
– volume: 50
  start-page: 823
  year: 2006
  ident: 2515_CR97
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.05.019
– volume: 279
  start-page: 11521
  year: 2004
  ident: 2515_CR13
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306766200
– volume: 2
  start-page: 7
  year: 2006
  ident: 2515_CR78
  publication-title: Plant Methods
  doi: 10.1186/1746-4811-2-7
– volume: 231
  start-page: 13
  year: 1998
  ident: 2515_CR45
  publication-title: Chem Phys
  doi: 10.1016/S0301-0104(98)00080-9
– volume: 6
  start-page: 557
  year: 1999
  ident: 2515_CR49
  publication-title: Nat Struct Biol
  doi: 10.1038/10763
– volume: 89
  start-page: 1317
  year: 2005
  ident: 2515_CR59
  publication-title: Biophys J
  doi: 10.1529/biophysj.105.062836
– volume: 37
  start-page: 33
  year: 2005
  ident: 2515_CR4
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2004.02.006
– volume: 7
  start-page: 668
  year: 2008
  ident: 2515_CR68
  publication-title: Photochem Photobiol Sci
  doi: 10.1039/b800391b
– volume: 114
  start-page: 2929
  year: 2001
  ident: 2515_CR75
  publication-title: J Cell Sci
  doi: 10.1242/jcs.114.16.2929
– volume: 107
  start-page: 1263
  year: 2003
  ident: 2515_CR56
  publication-title: J Phys Chem B
  doi: 10.1021/jp026454v
– volume: 95
  start-page: 6803
  year: 1998
  ident: 2515_CR44
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.95.12.6803
– volume: 44
  start-page: 643
  year: 2008
  ident: 2515_CR93
  publication-title: Biotechniques
  doi: 10.2144/000112798
– volume: 40
  start-page: 120
  year: 2007
  ident: 2515_CR31
  publication-title: Acc Chem Res
  doi: 10.1021/ar040086r
– volume: 77
  start-page: 2638
  year: 1999
  ident: 2515_CR58
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(99)77097-9
– volume: 128
  start-page: 4766
  year: 2006
  ident: 2515_CR39
  publication-title: J Am Chem Soc
  doi: 10.1021/ja0580439
– volume: 70
  start-page: 030901
  year: 2004
  ident: 2515_CR99
  publication-title: Phys Rev E
  doi: 10.1103/PhysRevE.70.030901
– volume: 9
  start-page: 528
  year: 2008
  ident: 2515_CR60
  publication-title: Traffic
  doi: 10.1111/j.1600-0854.2007.00696.x
– volume: 301
  start-page: 157
  year: 2000
  ident: 2515_CR37
  publication-title: J Mol Biol
  doi: 10.1006/jmbi.2000.3905
– volume: 23
  start-page: 605
  year: 2005
  ident: 2515_CR26
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2005.10.005
– volume: 94
  start-page: 2306
  year: 1997
  ident: 2515_CR35
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.6.2306
– volume: 274
  start-page: 37
  year: 2001
  ident: 2515_CR101
  publication-title: Chem Phys
  doi: 10.1016/S0301-0104(01)00486-4
– volume: 101
  start-page: 17988
  year: 2004
  ident: 2515_CR51
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0404262102
– volume: 326
  start-page: 1
  year: 2004
  ident: 2515_CR84
  publication-title: Gene
  doi: 10.1016/j.gene.2003.10.018
– volume: 435
  start-page: 1197
  year: 2005
  ident: 2515_CR5
  publication-title: Nature
  doi: 10.1038/nature03692
– volume: 100
  start-page: 99
  year: 2000
  ident: 2515_CR10
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81687-6
– volume: 111
  start-page: 229
  year: 1992
  ident: 2515_CR24
  publication-title: Gene
  doi: 10.1016/0378-1119(92)90691-H
– volume: 21
  start-page: 1347
  year: 2003
  ident: 2515_CR62
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt895
– volume: 159
  start-page: 1087
  year: 2002
  ident: 2515_CR8
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200208050
– volume: 30
  start-page: 127
  year: 1989
  ident: 2515_CR20
  publication-title: Methods Cell Biol
  doi: 10.1016/S0091-679X(08)60978-4
– volume: 46
  start-page: 12005
  year: 2007
  ident: 2515_CR80
  publication-title: Biochemistry
  doi: 10.1021/bi7009037
– volume: 73
  start-page: 674
  year: 1997
  ident: 2515_CR11
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(97)78102-5
– volume: 115
  start-page: 1505
  year: 1991
  ident: 2515_CR15
  publication-title: J Cell Biol
  doi: 10.1083/jcb.115.6.1505
– volume: 6
  start-page: 1267
  year: 1998
  ident: 2515_CR71
  publication-title: Structure
  doi: 10.1016/S0969-2126(98)00127-0
– volume: 278
  start-page: 44645
  year: 2003
  ident: 2515_CR3
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M308099200
– volume: 46
  start-page: 5494
  year: 2007
  ident: 2515_CR43
  publication-title: Biochemistry
  doi: 10.1021/bi602646r
– volume: 15
  start-page: 1313
  year: 2007
  ident: 2515_CR61
  publication-title: Molec Ther
  doi: 10.1038/sj.mt.6300172
– volume: 127
  start-page: 15491
  year: 2005
  ident: 2515_CR66
  publication-title: J Am Chem Soc
  doi: 10.1021/ja053909w
– volume: 127
  start-page: 626
  year: 2005
  ident: 2515_CR54
  publication-title: J Am Chem Soc
  doi: 10.1021/ja045400r
– volume: 112
  start-page: 519
  year: 2003
  ident: 2515_CR12
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00112-0
– volume: 275
  start-page: 6047
  year: 2000
  ident: 2515_CR73
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.9.6047
– volume: 94
  start-page: 986
  year: 2008
  ident: 2515_CR89
  publication-title: Biophys J
  doi: 10.1529/biophysj.107.111773
– volume: 6
  start-page: 328
  year: 2005
  ident: 2515_CR98
  publication-title: Chemphyschem
  doi: 10.1002/cphc.200400318
– volume: 93
  start-page: 8362
  year: 1996
  ident: 2515_CR46
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.93.16.8362
– volume: 47
  start-page: 121
  year: 2006
  ident: 2515_CR52
  publication-title: Methods Biochem Anal
  doi: 10.1002/0471739499.ch6
– volume: 93
  start-page: 13617
  year: 1996
  ident: 2515_CR32
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.93.24.13617
– volume: 74
  start-page: 1591
  year: 1998
  ident: 2515_CR53
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(98)77870-1
– volume: 24
  start-page: 581
  year: 1993
  ident: 2515_CR82
  publication-title: Micron
  doi: 10.1016/0968-4328(93)90035-Y
– ident: 2515_CR92
– volume: 280
  start-page: 26248
  year: 2005
  ident: 2515_CR38
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M412327200
– volume: 67
  start-page: 509
  year: 1998
  ident: 2515_CR23
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.67.1.509
– volume: 263
  start-page: 802
  year: 1994
  ident: 2515_CR25
  publication-title: Science
  doi: 10.1126/science.8303295
– volume: 104
  start-page: 4791
  year: 2000
  ident: 2515_CR36
  publication-title: J Phys Chem B
  doi: 10.1021/jp9942522
– volume: 128
  start-page: 12038
  year: 2006
  ident: 2515_CR41
  publication-title: J Am Chem Soc
  doi: 10.1021/ja063128a
– volume: 130
  start-page: 1227
  year: 2008
  ident: 2515_CR102
  publication-title: J Am Chem Soc
  doi: 10.1021/ja0754507
– ident: 2515_CR86
  doi: 10.1007/s00216-008-2489-7
– volume: 2
  start-page: 905
  year: 2005
  ident: 2515_CR28
  publication-title: Nat Methods
  doi: 10.1038/nmeth819
– volume: 41
  start-page: 15489
  year: 2002
  ident: 2515_CR47
  publication-title: Biochemistry
  doi: 10.1021/bi026610o
– volume: 48
  start-page: 189
  year: 2005
  ident: 2515_CR27
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.10.003
– volume: 274
  start-page: 8093
  year: 1999
  ident: 2515_CR9
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.12.8093
– volume: 93
  start-page: 232
  year: 2007
  ident: 2515_CR85
  publication-title: Biophys J
  doi: 10.1529/biophysj.106.102319
– volume: 43
  start-page: 238
  year: 2006
  ident: 2515_CR6
  publication-title: J Vasc Res
  doi: 10.1159/000091235
– volume: 94
  start-page: 2320
  year: 2008
  ident: 2515_CR95
  publication-title: Biophys J
  doi: 10.1529/biophysj.107.114645
– volume: 516
  start-page: 217
  year: 2002
  ident: 2515_CR17
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(02)02535-8
SSID ssj0015816
Score 2.3472948
SecondaryResourceType review_article
Snippet Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells...
SourceID proquest
pubmed
crossref
springer
fao
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1107
SubjectTerms absorption
Analytical Chemistry
Biochemistry
Biomedical materials
biosensors
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
dyes
Dynamics
Flow Cytometry
Fluorescence
fluorescence microscopy
Fluorescence/luminescence
Food Science
gene expression
green fluorescent protein
Green Fluorescent Proteins
Green Fluorescent Proteins - chemistry
Hydrogen-Ion Concentration
image analysis
In vivo tests
Indicators
Laboratory Medicine
Microscopy, Fluorescence
monitoring
Monitoring/Environmental Analysis
Optical sensors
pH measurements
phenol
Proteins
Review
Spectroscopy/theory
Surgical implants
Title Green fluorescent protein based pH indicators for in vivo use: a review
URI https://link.springer.com/article/10.1007/s00216-008-2515-9
https://www.ncbi.nlm.nih.gov/pubmed/19034433
https://www.proquest.com/docview/1744705040
https://www.proquest.com/docview/33205986
https://www.proquest.com/docview/46169674
https://www.proquest.com/docview/66891446
https://www.proquest.com/docview/753694046
Volume 393
WOSCitedRecordID wos000263127500003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1618-2650
  dateEnd: 20101231
  omitProxy: false
  ssIdentifier: ssj0015816
  issn: 1618-2642
  databaseCode: M7P
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1618-2650
  dateEnd: 20101231
  omitProxy: false
  ssIdentifier: ssj0015816
  issn: 1618-2642
  databaseCode: 7X7
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Materials Science Database
  customDbUrl:
  eissn: 1618-2650
  dateEnd: 20101231
  omitProxy: false
  ssIdentifier: ssj0015816
  issn: 1618-2642
  databaseCode: KB.
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/materialsscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1618-2650
  dateEnd: 20101231
  omitProxy: false
  ssIdentifier: ssj0015816
  issn: 1618-2642
  databaseCode: BENPR
  dateStart: 20010101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1618-2650
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015816
  issn: 1618-2642
  databaseCode: RSV
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ra9RAEB-8VrBffGvj41zBT0okd5t9-c2W1oJyHK2V-xY2m105KEm53N3f35k8TsRG0C8hC5OwO_uYGX6zvwF4FxRHO6JlnNpApNqGx6YoCnzL0TviXk1Mc1H4m5rN9GJh5t097rrPdu8hyeak3l12I3OE0W-CM4tGODYj2Edrp2k3nl_82EEHQjf1TokIntK3pj2UedsvfjNGo2Cr2_zMPzDSxvScPvivTj-E-52nyT63S-MR3PHlY7h33Bd4ewJfmpwbFq421aoldWINa8OyZGTbCnZ9xgjRdhSX1wy9W2yy7XJbsU3tPzHL2nsvT-Hy9OT78Vnc1VWIneByHcvC2lyIXOXWpEJoG4TOlQ5COOU0t0ESmFboXAvyD4x1UhXoZ5ngldEu8GewV1alPwSWeBscn1rjZZ7KJDfSTUwxMcqLkIRpHkHSKzhzHek41b64ynZ0yY2GMiqGSRrKTATvd59ct4wbfxM-xFnL7E88EbPLiynhsOigYVDMI3jbT2WGiiUcxJa-2tQZBmGpSgQeXxG8GZDhfJoQdf2wRCon0kiVDktIqQ2F2xGwAQmMFSV2lkSet4vt15ANkTFyHMaHfmVl3fFSD-vjxT9Jv4SDFhyj7JxXsLdebfxruOu262W9GsNILVTz1GPYPzqZzc-x9fXo45gSZOfjZtvdABIYHXk
linkProvider Springer Nature
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ra9RAEB9sFeoX39r46gp-UgK5bPblNynWE89DbCv9tmw2u3JQLuVyd3-_M3mciI2g3xKYhM3sZh78Zn4D8Doqjn5Ey7RwkUi1DU9NVVV4VWJ0xIOamLZReKbmc31xYb72fdzNUO0-QJKtpd41u5E7wuw3w51FJ5yaPbhZoMOiOr5vp9930IHQ7bxTIoKn8q18gDKve8Vvzmgvuvq6OPMPjLR1PSd3_2vR9-BOH2my993RuA83wvIBHBwPA94ewse25obFy0296kidWMvasFgy8m0Vu5oyQrQ95eUNw-gWb9l2sa3ZpgnvmGNd38sjOD_5cHY8Tfu5CqkXXK5TWTlXClGq0plCCO2i0KXSUQivvOYuSgLTKl1qQfGBcV6qCuMsE4My2kf-GPaX9TIcAsuCi57nzgRZFjIrjfQTU02MCiJmMS8TyAYFW9-TjtPsi0u7o0tuNWRpGCZpyJoE3uweueoYN_4mfIi7Zt0PtIj2_DQnHBYDNEyKeQKvhq20qFjCQdwy1JvGYhJWqEyg-UrgaESG8zwj6vpxiUJOpJGqGJeQUhtKtxNgIxKYK0pcLIk86Q7br082RMbI8TPeDifL9ualGdfH03-SPoKD6dmXmZ19mn9-Brc7oIwqdZ7D_nq1CS_glt-uF83qZfuL_QTkVxsj
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEF9sFe2Ln9XGr67gkxKay2a_fJPqWbEchVrp27K72ZWDkhyXu_v7O5OPE7ERxLcEJiE7s9mZ4TfzG0LeRsnAjyiRFjYiqbZmqS7LEq4cREcsyIluG4VP5WymLi_1WT_ntBmq3QdIsutpQJamanW0KOPRtvENXRNkwhlYGRxyqnfI7QJnBmG6fv5jCyNw1c4-RVJ4LOXKB1jzplf85ph2oq1vijn_wEtbNzR98N8LeEju9xEo_dhtmUfkVqgek3vHw-C3J-RLW4tD49W6XnZkT7Rlc5hXFH1eSRcnFJFuj_l6QyHqhVu6mW9qum7CB2pp1w-zTy6mn78fn6T9vIXUcyZWqSitdZw76awuOFc2cuWkipx76RWzUSDIViqnOMYN2nohS4i_dAxSKx_ZU7Jb1VU4IDQLNnqWWx2EK0TmtPATXU60DDxmMXcJyQZlG9-TkeNMjCuzpVFuNWRwSCZqyOiEvNs-suiYOP4mfAAWNPYnnJTm4jxHfBYCN0iWWULeDGY1oFjER2wV6nVjIDkrZMbhWEvI4YgMY3mGlPbjEoWYCC1kMS4hhNKYhieEjkhADingY1HkWbfxfi1ZI0kjg2W8H3aZ6Y-dZlwfz_9J-pDcPfs0NadfZ99ekL0OP8MCnpdkd7Vch1fkjt-s5s3ydfu3XQO7VCQH
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Green+fluorescent+protein+based+pH+indicators+for+in+vivo+use%3A+a+review&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.au=Bizzarri%2C+Ranieri&rft.au=Serresi%2C+Michela&rft.au=Luin%2C+Stefano&rft.au=Beltram%2C+Fabio&rft.date=2009-02-01&rft.issn=1618-2642&rft.eissn=1618-2650&rft.volume=393&rft.issue=4&rft.spage=1107&rft.epage=1122&rft_id=info:doi/10.1007%2Fs00216-008-2515-9&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s00216_008_2515_9
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1618-2642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1618-2642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1618-2642&client=summon