Nanoscale delivery systems for microRNAs in cancer therapy

Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer therapies have been raised. The answer to this problem may come from the world of nanoparticles such as liposomes, exosomes, polymers, dendrimer...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS Vol. 77; no. 6; pp. 1059 - 1086
Main Authors: Boca, Sanda, Gulei, Diana, Zimta, Alina-Andreea, Onaciu, Anca, Magdo, Lorand, Tigu, Adrian Bogdan, Ionescu, Calin, Irimie, Alexandru, Buiga, Rares, Berindan-Neagoe, Ioana
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.03.2020
Springer Nature B.V
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biomolecules
Cancer therapies
cancer therapy
Carcinogenesis
Carcinogens
Cell Biology
Chemotherapy
Dendrimers
Drug Carriers - chemistry
Drug Delivery Systems - methods
drug therapy
Exosomes
Gene Transfer Techniques
Genetic Therapy - methods
Genomics
Humans
Life Sciences
Liposomes
Medicine
microRNA
MicroRNAs
MicroRNAs - administration & dosage
MicroRNAs - genetics
MicroRNAs - pharmacokinetics
MicroRNAs - therapeutic use
miRNA
Nanomedicine - methods
Nanoparticles
Nanoparticles - chemistry
neoplasms
Neoplasms - genetics
Neoplasms - therapy
Oncology
Permeability
Pharmacy
Polymers
porous media
Quantum dots
Restoration
Review
Silica
Silicon dioxide
Toxicity
Tumor suppressor genes
Nanoparticles
miRNA therapy
Nanodelivery
Cancer
ISSN:1420-682X, 1420-9071, 1420-9071
Online Access:Get full text
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Summary:Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer therapies have been raised. The answer to this problem may come from the world of nanoparticles such as liposomes, exosomes, polymers, dendrimers, mesoporous silica nanoparticles, quantum dots and metal-based nanoparticles which have been proved as versatile and valuable vehicles for many biomolecules including miRNAs. In another train of thoughts, the general scheme of miRNA modulation consists in inhibition of oncomiRNA expression and restoration of tumor suppressor ones. The codelivery of two miRNAs or miRNAs in combination with chemotherapeutics or small molecules was also proposed. The present review presents the latest advancements in miRNA delivery based on nanoparticle-related strategies.
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ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-019-03317-9