Nanoscale delivery systems for microRNAs in cancer therapy

Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer therapies have been raised. The answer to this problem may come from the world of nanoparticles such as liposomes, exosomes, polymers, dendrimer...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cellular and molecular life sciences : CMLS Jg. 77; H. 6; S. 1059 - 1086
Hauptverfasser: Boca, Sanda, Gulei, Diana, Zimta, Alina-Andreea, Onaciu, Anca, Magdo, Lorand, Tigu, Adrian Bogdan, Ionescu, Calin, Irimie, Alexandru, Buiga, Rares, Berindan-Neagoe, Ioana
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cham Springer International Publishing 01.03.2020
Springer Nature B.V
Schlagworte:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biomolecules
Cancer therapies
cancer therapy
Carcinogenesis
Carcinogens
Cell Biology
Chemotherapy
Dendrimers
Drug Carriers - chemistry
Drug Delivery Systems - methods
drug therapy
Exosomes
Gene Transfer Techniques
Genetic Therapy - methods
Genomics
Humans
Life Sciences
Liposomes
Medicine
microRNA
MicroRNAs
MicroRNAs - administration & dosage
MicroRNAs - genetics
MicroRNAs - pharmacokinetics
MicroRNAs - therapeutic use
miRNA
Nanomedicine - methods
Nanoparticles
Nanoparticles - chemistry
neoplasms
Neoplasms - genetics
Neoplasms - therapy
Oncology
Permeability
Pharmacy
Polymers
porous media
Quantum dots
Restoration
Review
Silica
Silicon dioxide
Toxicity
Tumor suppressor genes
Nanoparticles
miRNA therapy
Nanodelivery
Cancer
ISSN:1420-682X, 1420-9071, 1420-9071
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer therapies have been raised. The answer to this problem may come from the world of nanoparticles such as liposomes, exosomes, polymers, dendrimers, mesoporous silica nanoparticles, quantum dots and metal-based nanoparticles which have been proved as versatile and valuable vehicles for many biomolecules including miRNAs. In another train of thoughts, the general scheme of miRNA modulation consists in inhibition of oncomiRNA expression and restoration of tumor suppressor ones. The codelivery of two miRNAs or miRNAs in combination with chemotherapeutics or small molecules was also proposed. The present review presents the latest advancements in miRNA delivery based on nanoparticle-related strategies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-019-03317-9