Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas

Preeclampsia (PE) is a leading cause of pregnancy complications, affecting 3–7% of pregnant women worldwide. The pathophysiology of preeclampsia involves a redox imbalance, oxidative stress and a reduced nitric oxide (NO) bioavailability. The molecular and cellular mechanisms leading to the dysfunct...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 141; pp. 416 - 425
Main Authors:	Guerby, Paul, Swiader, Audrey, Tasta, Oriane, Pont, Frédéric, Rodriguez, Frédéric, Parant, Olivier, Vayssière, Christophe, Shibata, Takahiro, Uchida, Koji, Salvayre, Robert, Negre-Salvayre, Anne
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2019 Elsevier
Subjects:	4-Hydroxynonenal 4-Oxo-2(E)-nonenal Acrolein Biochemistry, Molecular Biology Bioinformatics Biophysics Chemical Sciences Cheminformatics Computer Science Invasion Life Sciences Medicinal Chemistry Modeling and Simulation Nitric oxide Placental eNOS Preeclampsia Structural Biology Trophoblasts NO eNOS 4-Hydroxynonenal ONE 4-Oxo-2(E)-nonenal LPP Invasion Placental eNOS Acrolein Trophoblasts PE Preeclampsia Nitric oxide Lys (K)
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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