Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study

Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare the clinical and laboratory findings observed in a cohort of MOG-Ab seropositive and seronegative...

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Veröffentlicht in:Journal of neurology Jg. 264; H. 12; S. 2420 - 2430
Hauptverfasser: Mariotto, Sara, Ferrari, Sergio, Monaco, Salvatore, Benedetti, Maria Donata, Schanda, Kathrin, Alberti, Daniela, Farinazzo, Alessia, Capra, Ruggero, Mancinelli, Chiara, De Rossi, Nicola, Bombardi, Roberto, Zuliani, Luigi, Zoccarato, Marco, Tanel, Raffaella, Bonora, Adriana, Turatti, Marco, Calabrese, Massimiliano, Polo, Alberto, Pavone, Antonino, Grazian, Luisa, Sechi, GianPietro, Sechi, Elia, Urso, Daniele, Delogu, Rachele, Janes, Francesco, Deotto, Luciano, Cadaldini, Morena, Bianchi, Maria Rachele, Cantalupo, Gaetano, Reindl, Markus, Gajofatto, Alberto
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2017
Springer Nature B.V
Schlagworte:
Aquaporin 4
Central nervous system
Demyelinating diseases
Demyelination
Glycoproteins
Immunofluorescence
Immunoglobulin G
Immunoglobulins
Laboratories
Magnetic resonance imaging
Medicine
Medicine & Public Health
Myelin
Neurology
Neuroradiology
Neurosciences
Oligodendrocyte-myelin glycoprotein
Optic nerve
Original Communication
Spinal cord
Myelitis
Neuromyelitis optica spectrum disorders (NMOSD)
Acute disseminated encephalomyelitis (ADEM)
Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies
Multiple sclerosis (MS)
Optic neuritis
ISSN:0340-5354, 1432-1459, 1432-1459
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Zusammenfassung:Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare the clinical and laboratory findings observed in a cohort of MOG-Ab seropositive and seronegative cases and describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or MOG-Ab testing were analysed between March 2014 and May 2017. The presence of AQP4-Ab was determined using a cell-based assay. A live cell immunofluorescence assay was used for the detection of MOG-IgG and IgG subclass analysis. Among 454 analysed samples, 29 were excluded due to AQP4-Ab positivity or to the final demonstration of a disorder not compatible with MOG-Ab. We obtained clinical data in 154 out of 425 cases. Of these, 22 subjects resulted MOG-Ab positive. MOG-Ab positive patients were mainly characterised by the involvement of the optic nerve and/or spinal cord. Half of the cases presented relapses and the recovery was usually partial. Brain MRI was heterogeneous while short lesions were the prevalent observation on spinal cord MRI. MOG-Ab titre usually decreased in non-relapsing cases. In all MOG-IgG positive cases, we observed IgG1 antibodies, which were predominant in most subjects. IgG2 (5/22), IgG3 (9/22) and IgG4 (3/22) antibodies were also detectable. We confirm that MOG-Ab-related syndromes have distinct features in the spectrum of demyelinating conditions, and we describe the possible role of the different IgG subclasses in this condition.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-017-8635-4