A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma

Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary tract. Several fibroblast growth factor receptor (FGFR) inhibitors are currently in clinical development and response rates appear promising for advanced UCC. A c...

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Bibliographic Details
Published in:	European urology Vol. 71; no. 6; pp. 858 - 862
Main Authors:	Wang, Liqin, Šuštić, Tonći, Leite de Oliveira, Rodrigo, Lieftink, Cor, Halonen, Pasi, van de Ven, Marieke, Beijersbergen, Roderick L., van den Heuvel, Michel M., Bernards, René, van der Heijden, Michiel S.
Format:	Journal Article
Language:	English
Published:	Switzerland Elsevier B.V 01.06.2017
Subjects:	Aminopyridines - pharmacology Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Benzamides - pharmacology Bladder cancer Carcinoma - drug therapy Carcinoma - enzymology Carcinoma - genetics Carcinoma - pathology Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Dose-Response Relationship, Drug Drug Resistance, Neoplasm - genetics Drug Synergism FGFR Humans Mice, Nude Molecular Targeted Therapy Morpholines - pharmacology Mutation PI3K Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Pyrazoles - pharmacology Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism RNA Interference Signal Transduction - drug effects Synergy Time Factors Transfection Tumor Burden - drug effects Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urology Urothelium - drug effects Urothelium - enzymology Urothelium - pathology Xenograft Model Antitumor Assays Synergy PI3K FGFR Bladder cancer
ISSN:	0302-2838, 1873-7560, 1873-7560
Online Access:	Get full text
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