IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the genes encoding IDHs are frequently mutated in a variety...

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Bibliographic Details
Published in:	British journal of cancer Vol. 122; no. 11; pp. 1580 - 1589
Main Authors:	Han, Sue, Liu, Yang, Cai, Sabrina J., Qian, Mingyu, Ding, Jianyi, Larion, Mioara, Gilbert, Mark R., Yang, Chunzhang
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.05.2020 Nature Publishing Group
Subjects:	631/208/737 631/80 Acute myeloid leukemia Animals Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Cancer Research Cell Transformation, Neoplastic - genetics Cholangiocarcinoma Chondrosarcoma Decarboxylation Drug Resistance Epidemiology Glioma Glioma - genetics Humans Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Leukemia Molecular Medicine Molecular modelling Mutants Mutation Oncology Review Review Article Therapeutic applications Thyroid cancer Thyroid carcinoma Tricarboxylic acid cycle Tumorigenesis
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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