The emerging role of exosomes in mental disorders

Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in pro...

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Vydáno v:	Translational psychiatry Ročník 9; číslo 1; s. 122
Hlavní autoři:	Saeedi, Saumeh, Israel, Sonia, Nagy, Corina, Turecki, Gustavo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 28.03.2019 Nature Publishing Group
Témata:	631/378 692/53 Behavioral Sciences Biological Psychology Biomarkers Blood-Brain Barrier - physiopathology Brain - physiopathology Cell Communication Exosomes - physiology Humans Medicine Medicine & Public Health Mental disorders Mental Disorders - physiopathology Neurosciences Pharmacotherapy Psychiatry Review Review Article
ISSN:	2158-3188, 2158-3188
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood–brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.
AbstractList	Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood–brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders. Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood-brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood-brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.
ArticleNumber	122
Author	Israel, Sonia Nagy, Corina Saeedi, Saumeh Turecki, Gustavo
Author_xml	– sequence: 1 givenname: Saumeh surname: Saeedi fullname: Saeedi, Saumeh organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Department of Human Genetics, McGill University – sequence: 2 givenname: Sonia surname: Israel fullname: Israel, Sonia organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 3 givenname: Corina surname: Nagy fullname: Nagy, Corina organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University – sequence: 4 givenname: Gustavo orcidid: 0000-0003-4075-2736 surname: Turecki fullname: Turecki, Gustavo email: gustavo.turecki@mcgill.ca organization: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Department of Psychiatry, McGill University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30923321$$D View this record in MEDLINE/PubMed
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SubjectTerms	631/378 692/53 Behavioral Sciences Biological Psychology Biomarkers Blood-Brain Barrier - physiopathology Brain - physiopathology Cell Communication Exosomes - physiology Humans Medicine Medicine & Public Health Mental disorders Mental Disorders - physiopathology Neurosciences Pharmacotherapy Psychiatry Review Review Article
Title	The emerging role of exosomes in mental disorders
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