70-year legacy of the Framingham Heart Study

The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ve...

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Vydáno v:Nature reviews cardiology Ročník 16; číslo 11; s. 687 - 698
Hlavní autoři: Andersson, Charlotte, Johnson, Andrew D, Benjamin, Emelia J, Levy, Daniel, Vasan, Ramachandran S
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.11.2019
Témata:
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - history
Coronary Artery Disease - epidemiology
Data Collection - history
DNA methylation
Echocardiography
Epidemiology
Exercise Test
Genomics
Health risk assessment
Heart
History, 20th Century
History, 21st Century
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Manometry
Phenotype
Population Surveillance
Risk Factors
Tomography, X-Ray Computed
Whole genome sequencing
ISSN:1759-5002, 1759-5010, 1759-5010
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Abstract The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'omics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
AbstractList The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep ‘omics’ profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.The Framingham Heart Study (FHS) has been collecting epidemiological data on cardiovascular risk factors and disease for >70 years. In this Timeline Perspectives article, the authors summarize the major achievements of the FHS, highlight some of the seminal publications and discuss how epidemiological research has changed and continues to evolve.
The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'omics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'omics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'omics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.
Author Andersson, Charlotte
Benjamin, Emelia J
Vasan, Ramachandran S
Levy, Daniel
Johnson, Andrew D
Author_xml – sequence: 1
  givenname: Charlotte
  surname: Andersson
  fullname: Andersson, Charlotte
  email: ca@heart.dk, ca@heart.dk
  organization: Department of Cardiology, Gentofte and Herlev Hospital, Herlev, Denmark. ca@heart.dk
– sequence: 2
  givenname: Andrew D
  surname: Johnson
  fullname: Johnson, Andrew D
  organization: Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA
– sequence: 3
  givenname: Emelia J
  orcidid: 0000-0003-4076-2336
  surname: Benjamin
  fullname: Benjamin, Emelia J
  organization: Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
– sequence: 4
  givenname: Daniel
  surname: Levy
  fullname: Levy, Daniel
  organization: Preventive Medicine and Cardiology Sections, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
– sequence: 5
  givenname: Ramachandran S
  orcidid: 0000-0001-7357-5970
  surname: Vasan
  fullname: Vasan, Ramachandran S
  email: vasan@bu.edu, vasan@bu.edu, vasan@bu.edu
  organization: Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. vasan@bu.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31065045$$D View this record in MEDLINE/PubMed
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Snippet The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961,...
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SubjectTerms Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - history
Coronary Artery Disease - epidemiology
Data Collection - history
DNA methylation
Echocardiography
Epidemiology
Exercise Test
Genomics
Health risk assessment
Heart
History, 20th Century
History, 21st Century
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Manometry
Phenotype
Population Surveillance
Risk Factors
Tomography, X-Ray Computed
Whole genome sequencing
Title 70-year legacy of the Framingham Heart Study
URI https://www.ncbi.nlm.nih.gov/pubmed/31065045
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