Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

The polycomb repressive complex 2 (PRC2) regulates differentiation by contributing to repression of gene expression and thereby stabilizing the fate of stem cells and their progeny. PRC2 helps to maintain adult stem cell populations, but little is known about its functions in intestinal stem cells....

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 151; no. 4; pp. 684 - 697.e12
Main Authors:	Koppens, Martijn A J, Bounova, Gergana, Gargiulo, Gaetano, Tanger, Ellen, Janssen, Hans, Cornelissen-Steijger, Paulien, Blom, Marleen, Song, Ji-Ying, Wessels, Lodewyk F A, van Lohuizen, Maarten
Format:	Journal Article
Language:	English
Published:	United States 01.10.2016
Subjects:	Adult Stem Cells - physiology Animals Base Sequence Cell Differentiation Cell Lineage Cell Proliferation Chromatin Immunoprecipitation Enhancer of Zeste Homolog 2 Protein - deficiency Intestines - cytology Intestines - metabolism Mice Mice, Knockout Polycomb Repressive Complex 2 - deficiency Polycomb Repressive Complex 2 - genetics Wnt Signaling Pathway Development ISC PRC1 Small Intestine
ISSN:	1528-0012
Online Access:	Get more information
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