Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hosp...

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Veröffentlicht in:	The New England journal of medicine Jg. 360; H. 5; S. 439 - 443
Hauptverfasser:	Arias, Cesar A, Murray, Barbara E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Massachusetts Medical Society 29.01.2009
Schlagworte:	Antibiotics Drug resistance Drug Resistance, Multiple, Bacterial - genetics Enterococcus faecium - drug effects Enterococcus faecium - pathogenicity Gram-Negative Bacteria - pathogenicity Gram-Negative Bacterial Infections - drug therapy Hospitals Humans Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - pathogenicity Mutation Staphylococcus infections Vancomycin Resistance - genetics United States > US
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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Abstract	Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not eradicate her bloodstream infection. Then they managed to obtain a small amount of a newly discovered substance called penicillin, which they cautiously injected into her. After repeated doses, her bloodstream was cleared of streptococci, she made a full recovery, and she went on to live to the age of 90. 1 Sixty-six years after her startling recovery, a report 2 described a 70-year-old man in San Francisco with endocarditis caused by vancomycin-resistant . . .
AbstractList	Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not eradicate her bloodstream infection. Then they managed to obtain a small amount of a newly discovered substance called penicillin, which they cautiously injected into her. After repeated doses, her bloodstream was cleared of streptococci, she made a full recovery, and she went on to live to the age of 90. 1 Sixty-six years after her startling recovery, a report 2 described a 70-year-old man in San Francisco with endocarditis caused by vancomycin-resistant . . . A single clone, USA300, is responsible for most community-associated MRSA infections in the United States.3 Although such MRSA is commonly susceptible to oral antibiotics such as clindamycin, fluoroquinolones, trimethoprim-sulfamethoxazole, tetracyclines, and rifampin, some multidrug-resistant strains are emerging.
Author	Arias, Cesar A Murray, Barbara E
Author_xml	– sequence: 1 givenname: Cesar A surname: Arias fullname: Arias, Cesar A – sequence: 2 givenname: Barbara E surname: Murray fullname: Murray, Barbara E
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19179312$$D View this record in MEDLINE/PubMed
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Snippet	Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with... A single clone, USA300, is responsible for most community-associated MRSA infections in the United States.3 Although such MRSA is commonly susceptible to oral...
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SubjectTerms	Antibiotics Drug resistance Drug Resistance, Multiple, Bacterial - genetics Enterococcus faecium - drug effects Enterococcus faecium - pathogenicity Gram-Negative Bacteria - pathogenicity Gram-Negative Bacterial Infections - drug therapy Hospitals Humans Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - pathogenicity Mutation Staphylococcus infections Vancomycin Resistance - genetics
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Title	Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge
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