Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk a...
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| Vydáno v: | Gastroenterology (New York, N.Y. 1943) Ročník 147; číslo 2; s. 502 |
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| Hlavní autoři: | , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.08.2014
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| Témata: | |
| ISSN: | 1528-0012, 1528-0012 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Abstract | The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided. |
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| AbstractList | The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided. The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided. |
| Author | Church, James M Burke, Carol A Levin, Theodore R Robertson, Douglas J Johnson, David A Syngal, Sapna Giardiello, Francis M Kaltenbach, Tonya Lieberman, David A Axilbund, Jennifer E Dominitz, Jason A Allen, John I Burt, Randall W Rex, Douglas K Boland, C Richard |
| Author_xml | – sequence: 1 givenname: Francis M surname: Giardiello fullname: Giardiello, Francis M email: fgiardi@jhmi.edu organization: Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: fgiardi@jhmi.edu – sequence: 2 givenname: John I surname: Allen fullname: Allen, John I organization: Yale University School of Medicine, New Haven, Connecticut – sequence: 3 givenname: Jennifer E surname: Axilbund fullname: Axilbund, Jennifer E organization: Johns Hopkins University School of Medicine, Baltimore, Maryland – sequence: 4 givenname: C Richard surname: Boland fullname: Boland, C Richard organization: Baylor University Medical Center at Dallas, Texas – sequence: 5 givenname: Carol A surname: Burke fullname: Burke, Carol A organization: Cleveland Clinic, Cleveland, Ohio – sequence: 6 givenname: Randall W surname: Burt fullname: Burt, Randall W organization: University of Utah, Salt Lake City, Utah – sequence: 7 givenname: James M surname: Church fullname: Church, James M organization: Cleveland Clinic, Cleveland, Ohio – sequence: 8 givenname: Jason A surname: Dominitz fullname: Dominitz, Jason A organization: VA Puget Sound Health Care System, Seattle, Washington; University of Washington, Seattle, Washington – sequence: 9 givenname: David A surname: Johnson fullname: Johnson, David A organization: Eastern Virginia Medical School, Norfolk, Virginia – sequence: 10 givenname: Tonya surname: Kaltenbach fullname: Kaltenbach, Tonya organization: Stanford University, Palo Alto, California – sequence: 11 givenname: Theodore R surname: Levin fullname: Levin, Theodore R organization: Kaiser Permanente Medical Center, Walnut Creek, California – sequence: 12 givenname: David A surname: Lieberman fullname: Lieberman, David A organization: Oregon Health and Science University, Portland, Oregon – sequence: 13 givenname: Douglas J surname: Robertson fullname: Robertson, Douglas J organization: White River Junction VA Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, White River Junction, Vermont – sequence: 14 givenname: Sapna surname: Syngal fullname: Syngal, Sapna organization: Brigham and Women's Hospital, Boston, Massachusetts; Dana Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts – sequence: 15 givenname: Douglas K surname: Rex fullname: Rex, Douglas K organization: Indiana University School of Medicine, Indianapolis, Indiana |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25043945$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2014 American Gastroenterological Association, American College of Gastroenterology, the American Society of Colon and Rectal Surgeons, and the American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved. |
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| Keywords | Lynch Syndrome Colorectal Cancer Genetic Testing |
| Language | English |
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| PublicationTitle | Gastroenterology (New York, N.Y. 1943) |
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| SubjectTerms | Algorithms Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - therapy Gastroenterology - standards Genetic Predisposition to Disease Genetic Testing - standards Genetic Therapy - standards Humans Pedigree Predictive Value of Tests Prognosis Risk Assessment Risk Factors |
| Title | Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer |
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