Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models

Background Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM lo...

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Bibliographic Details
Published in:	British journal of cancer Vol. 123; no. 9; pp. 1424 - 1436
Main Authors:	Dunlop, Charles R., Wallez, Yann, Johnson, Timothy Isaac, Bernaldo de Quirós Fernández, Sandra, Durant, Stephen T., Cadogan, Elaine B., Lau, Alan, Richards, Frances M., Jodrell, Duncan I.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.10.2020 Nature Publishing Group
Subjects:	631/154/53/2423 631/67/1059/602 631/67/1059/99 631/67/1504/1713 631/80/86/2371 Adenocarcinoma Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - physiology Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Cell death Cell Line, Tumor Cell Proliferation - drug effects Clinical trials CRISPR Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - therapeutic use DNA-dependent protein kinase Drug Resistance Drug Synergism Epidemiology Female Flow cytometry Gemcitabine Gene Knockout Techniques Humans Immunoblotting Immunofluorescence Indoles Mice Mice, 129 Strain Mice, Inbred C57BL Molecular Medicine Morpholines Oncology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Precision medicine Pyridines - administration & dosage Pyridines - pharmacology Pyrimidines - administration & dosage Pyrimidines - pharmacology Quinolines - administration & dosage Quinolines - pharmacology Replication RNA, Small Interfering - pharmacology siRNA Sulfonamides Sulfoxides - administration & dosage Sulfoxides - pharmacology Tumors Xenograft Model Antitumor Assays Xenografts
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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