Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F 1 F O ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial uncoupling and enhanced ATP production efficiency while in contrast mutat...

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Bibliographic Details
Published in:	Cell death & disease Vol. 10; no. 6; pp. 469 - 12
Main Authors:	Chen, Rongmin, Park, Han-A, Mnatsakanyan, Nelli, Niu, Yulong, Licznerski, Pawel, Wu, Jing, Miranda, Paige, Graham, Morven, Tang, Jack, Boon, Agnita J. W., Cossu, Giovanni, Mandemakers, Wim, Bonifati, Vincenzo, Smith, Peter J. S., Alavian, Kambiz N., Jonas, Elizabeth A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.06.2019 Springer Nature B.V
Subjects:	13/31 14/19 14/28 42/109 631/378/1689 631/80/304 96/106 Animals Antibodies ATP synthase Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Dopamine receptors Dopaminergic Neurons - metabolism Gene Expression Humans Immunology Life Sciences Membrane Potential, Mitochondrial - genetics Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membranes - metabolism Mitochondrial Proton-Translocating ATPases - genetics Mitochondrial Proton-Translocating ATPases - metabolism Movement disorders Mutation Neurodegenerative diseases PARK7 protein Parkinson's disease Protein Binding Protein Deglycase DJ-1 - genetics Protein Deglycase DJ-1 - metabolism Proteins Rats, Sprague-Dawley Stoichiometry
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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