Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber

In a natural field study, sublingual tablets of house dust mite (HDM) allergen extracts (STG320) were efficacious in treating HDM-associated allergic rhinitis. We sought to assess the efficacy and safety of 3 doses of STG320 in an environmental exposure chamber. In this randomized, double-blind stud...

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Vydané v:	Journal of allergy and clinical immunology Ročník 138; číslo 2; s. 451 - 458.e5
Hlavní autori:	Roux, Michel, Devillier, Philippe, Yang, William H., Montagut, Armelle, Abiteboul, Kathy, Viatte, Agnès, Zeldin, Robert K.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.08.2016 Elsevier Limited
Predmet:	Adult Allergen immunotherapy allergic rhinitis Allergies Allergy and Immunology Antigens, Dermatophagoides - administration & dosage Antigens, Dermatophagoides - immunology Area Under Curve Asthma Dermatophagoides pteronyssinus dose-ranging double-blind placebo-controlled trial Environmental Exposure environmental exposure chamber Female Forced Expiratory Volume house dust mite Humans Immunoglobulin E - immunology Immunoglobulin G - immunology Immunotherapy Investigations Male Nose Rhinitis, Allergic - diagnosis Rhinitis, Allergic - immunology Rhinitis, Allergic - therapy Sublingual Immunotherapy - adverse effects Sublingual Immunotherapy - methods sublingual immunotherapy tablet Treatment Outcome Young Adult dose-ranging EEC house dust mite AE RTSS double-blind placebo-controlled trial IR VAS environmental exposure chamber AIT ARSS AUC ChBL AVASS HDM sublingual immunotherapy tablet TEAE ARTSS allergic rhinitis Allergen immunotherapy Average Rhinitis Symptom Score Visual Analog Scale Index of reactivity Rhinitis Total Symptom Score Area under the curve Ch BL Average Rhinitis Total Symptom Score Average Visual Analog Scale Score Change from baseline Adverse event Treatment-emergent adverse event
ISSN:	0091-6749, 1097-6825
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