Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury. However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives interstitial inflammation remains unclear. This paper aims to explore the role of exosomal miRNAs derived from T...

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Bibliographic Details
Published in:	Cell death and differentiation Vol. 27; no. 1; pp. 210 - 226
Main Authors:	Lv, Lin-Li, Feng, Ye, Wu, Min, Wang, Bin, Li, Zuo-Lin, Zhong, Xin, Wu, Wei-Jun, Chen, Jun, Ni, Hai-Feng, Tang, Tao-Tao, Tang, Ri-Ning, Lan, Hui-Yao, Liu, Bi-Cheng
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2020
Subjects:	Acute Kidney Injury - genetics Acute Kidney Injury - metabolism Adult Aged Animals Cell activation Cells, Cultured Diabetic Nephropathies - urine Diabetic nephropathy Epithelial cells Epithelial Cells - metabolism Exosomes - genetics Exosomes - metabolism Female Humans Inflammation Kidney - metabolism Kidney - pathology Kidney diseases Kidney Tubules - metabolism Macrophage Activation Macrophages Macrophages - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL MicroRNAs MicroRNAs - metabolism MicroRNAs - urine Middle Aged miRNA Nephritis - genetics Nephritis - pathology NF-kappa B - metabolism Proteinuria - chemically induced Proteinuria - genetics Proteinuria - metabolism RAW 264.7 Cells Suppressor of Cytokine Signaling 1 Protein - genetics Suppressor of Cytokine Signaling 1 Protein - metabolism
ISSN:	1350-9047, 1476-5403, 1476-5403
Online Access:	Get full text
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