Understanding the Dermoscopic Patterns of Basal Cell Carcinoma Using Line-Field Confocal Tomography

Basal cell carcinoma (BCC) is the most frequent malignancy in the general population. To date, dermoscopy is considered a key tool for the diagnosis of BCC; nevertheless, line-field confocal optical coherence tomography (LC-OCT), a new non-invasive optical technique, has become increasingly importan...

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Veröffentlicht in:Tomography (Ann Arbor) Jg. 10; H. 6; S. 826 - 838
Hauptverfasser: Barbarossa, Lorenzo, D’Onghia, Martina, Cartocci, Alessandra, Suppa, Mariano, Tognetti, Linda, Cappilli, Simone, Peris, Ketty, Perez-Anker, Javiera, Malvehy, Josep, Baldino, Gennaro, Militello, Caterina, Perrot, Jean Luc, Rubegni, Pietro, Cinotti, Elisa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 01.06.2024
MDPI
Schlagworte:
Adult
Aged
Aged, 80 and over
Basal cell carcinoma
Carcinoma, Basal Cell - diagnostic imaging
Carcinoma, Basal Cell - pathology
dermoscopy
Dermoscopy - methods
Female
Humans
imaging
Italy
LC-OCT
Male
Middle Aged
optical coherence tomography
Retrospective Studies
Skin
Skin Neoplasms - diagnostic imaging
Skin Neoplasms - pathology
Tomography, Optical Coherence - methods
Italy
basal cell carcinoma
LC-OCT
optical coherence tomography
imaging
dermoscopy
ISSN:2379-139X, 2379-1381, 2379-139X
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Zusammenfassung:Basal cell carcinoma (BCC) is the most frequent malignancy in the general population. To date, dermoscopy is considered a key tool for the diagnosis of BCC; nevertheless, line-field confocal optical coherence tomography (LC-OCT), a new non-invasive optical technique, has become increasingly important in clinical practice, allowing for in vivo imaging at cellular resolution. The present study aimed to investigate the possible correlation between the dermoscopic features of BCC and their LC-OCT counterparts. In total, 100 histopathologically confirmed BCC cases were collected at the Dermatologic Clinic of the University of Siena, Italy. Predefined dermoscopic and LC-OCT criteria were retrospectively evaluated, and their frequencies were calculated. The mean (SD) age of our cohort was 65.46 (13.36) years. Overall, BCC lesions were mainly located on the head (49%), and they were predominantly dermoscopically pigmented (59%). Interestingly, all dermoscopic features considered had a statistically significant agreement with the LC-OCT criteria (all p < 0.05). In conclusion, our results showed that dermoscopic patterns may be associated with LC-OCT findings, potentially increasing accuracy in BCC diagnosis. However, further studies are needed in this field.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2379-139X
2379-1381
2379-139X
DOI:10.3390/tomography10060063