Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics

The blood‐brain barrier (BBB) prevents the majority of drugs from crossing into the brain and reaching neurons. To overcome this challenge, safe and non‐invasive technologies targeting receptor‐mediated pathways have been developed. In this study, three single‐domain antibodies (sdAbs; IGF1R3, IGF1R...

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Bibliographic Details
Published in:	The FASEB journal Vol. 36; no. 3; pp. e22208 - n/a
Main Authors:	Alata, Wael, Yogi, Alvaro, Brunette, Eric, Delaney, Christie E., Faassen, Henk, Hussack, Greg, Iqbal, Umar, Kemmerich, Kristin, Haqqani, Arsalan S., Moreno, Maria J., Stanimirovic, Danica B.
Format:	Journal Article
Language:	English
Published:	United States 01.03.2022
Subjects:	Animals Blood-Brain Barrier - metabolism blood‐brain barrier Capillary Permeability Cell Line Cells, Cultured galanin in situ brain perfusion inflammatory pain insulin growth factor 1 receptor Male Mice Mice, Inbred BALB C Rats Rats, Sprague-Dawley Receptor, IGF Type 1 - immunology receptor‐mediated transcytosis Single-Chain Antibodies - immunology Single-Chain Antibodies - pharmacokinetics blood-brain barrier inflammatory pain galanin in situ brain perfusion insulin growth factor 1 receptor receptor-mediated transcytosis
ISSN:	0892-6638, 1530-6860, 1530-6860
Online Access:	Get full text
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