Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System

Chronic inflammatory diseases are influenced by dysregulation of cytokines. Among them, granulocyte macrophage colony stimulating factor (GM-CSF) is crucial for the pathogenic function of T cells in preclinical models of autoimmunity. To study the impact of dysregulated GM-CSF expression in vivo, we...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 46; no. 2; p. 245
Main Authors:	Spath, Sabine, Komuczki, Juliana, Hermann, Mario, Pelczar, Pawel, Mair, Florian, Schreiner, Bettina, Becher, Burkhard
Format:	Journal Article
Language:	English
Published:	United States 21.02.2017
Subjects:	Animals Central Nervous System - immunology Central Nervous System - pathology Flow Cytometry Granulocyte-Macrophage Colony-Stimulating Factor - immunology Immunohistochemistry Mice Mice, Inbred C57BL Mice, Transgenic Models, Animal Phagocytes - immunology Polymerase Chain Reaction moDCs myeloid cells phagocytes GM-CSF inflammatory monocytes multiple sclerosis reactive oxygen species cytokines brain CNS inflammation histiocytosis
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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