High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse

Resistance to therapy and subsequent relapse remain major challenges in the clinical management of relapsed childhood acute lymphoblastic leukemia. As the bone marrow environment plays an important role in survival and chemotherapy resistance of leukemia cells by activating different signaling pathw...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 96; no. 11; pp. 1627 - 1635
Main Authors:	Shalapour, S., Hof, J., Kirschner-Schwabe, R., Bastian, L., Eckert, C., Prada, J., Henze, G., von Stackelberg, A., Seeger, K.
Format:	Journal Article
Language:	English
Published:	Pavia Ferrata Storti Foundation 01.11.2011
Subjects:	Adolescent Antineoplastic Combined Chemotherapy Protocols - administration & dosage Asparaginase - administration & dosage Biological and medical sciences Child Child, Preschool Daunorubicin - administration & dosage Disease-Free Survival Drug Resistance, Neoplasm Gene Expression Regulation, Leukemic Hematologic and hematopoietic diseases Humans Integrin alpha4beta1 - biosynthesis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Original Research Phosphatidylinositol 3-Kinases - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Prednisone - administration & dosage Proto-Oncogene Proteins c-akt - metabolism Recurrence Retrospective Studies Signal Transduction - drug effects Survival Rate Vincristine - administration & dosage Human Relapse Prognosis Hematology prognosis markers Cell adhesion molecule Biological marker Malignant hemopathy Gene expression Precursor B cell acute lymphoblastic leukemia VLA-4 α4β1 integrin acute lymphoblastic leukemia stromal cells Lymphoproliferative syndrome Complication Stromal cell Acute lymphocytic leukemia Child Cancer
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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