Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin

Recent studies demonstrated that inhibitors of pro-inflammatory molecular cascades triggered by rabies infection in the central nervous system (CNS) can enhance survival in mouse model and that certain antiviral compounds interfere with rabies virus replication in vitro. In this study different comb...

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Veröffentlicht in:	Vaccine Jg. 37; H. 33; S. 4724 - 4735
Hauptverfasser:	Marosi, András, Dufkova, Lucie, Forró, Barbara, Felde, Orsolya, Erdélyi, Károly, Širmarová, Jana, Palus, Martin, Hönig, Václav, Salát, Jiří, Tikos, Réka, Gyuranecz, Miklós, Růžek, Daniel, Martina, Byron, Koraka, Penelope, Osterhaus, Albert D.M.E., Bakonyi, Tamás
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 02.08.2019 Elsevier Limited
Schlagworte:	Allergy and Immunology animal models Animals Antibodies antiviral agents Antiviral drugs Bats Blood-brain barrier Brain research Cascades Caspase Caspase-1 Central nervous system Combination Combination therapy Cytokines Disease Encephalitis enzyme inhibitors Experiments Exposure Fatalities Food chains HRIG humans Immune system Immunoglobulins Immunology Immunomodulation Immunotherapy Infections Inflammation Infliximab Inhibitor drugs Inhibitors Interferon interferons Kinases Lasionycteris noctivagans lethal dose 50 Lyssavirus Mannitol mice Monoclonal antibodies necrosis neoplasms Pathogenesis Rabies Rabies lyssavirus Rabies virus Ribavirin Sorafenib Survival survival rate Targeted cancer therapy therapeutics TNF inhibitors Toxicity tumor necrosis factor-alpha Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors vaccines viral load virus replication Viruses St Louis Missouri United States > US Czech Republic HRIG Infliximab Rabies virus Survival Combination Sorafenib
ISSN:	0264-410X, 1873-2518, 1873-2518
Online-Zugang:	Volltext
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