Combination therapy of rabies-infected mice with inhibitors of pro-inflammatory host response, antiviral compounds and human rabies immunoglobulin

Recent studies demonstrated that inhibitors of pro-inflammatory molecular cascades triggered by rabies infection in the central nervous system (CNS) can enhance survival in mouse model and that certain antiviral compounds interfere with rabies virus replication in vitro. In this study different comb...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Vaccine Ročník 37; číslo 33; s. 4724 - 4735
Hlavní autoři:	Marosi, András, Dufkova, Lucie, Forró, Barbara, Felde, Orsolya, Erdélyi, Károly, Širmarová, Jana, Palus, Martin, Hönig, Václav, Salát, Jiří, Tikos, Réka, Gyuranecz, Miklós, Růžek, Daniel, Martina, Byron, Koraka, Penelope, Osterhaus, Albert D.M.E., Bakonyi, Tamás
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 02.08.2019 Elsevier Limited
Témata:	Allergy and Immunology animal models Animals Antibodies antiviral agents Antiviral drugs Bats Blood-brain barrier Brain research Cascades Caspase Caspase-1 Central nervous system Combination Combination therapy Cytokines Disease Encephalitis enzyme inhibitors Experiments Exposure Fatalities Food chains HRIG humans Immune system Immunoglobulins Immunology Immunomodulation Immunotherapy Infections Inflammation Infliximab Inhibitor drugs Inhibitors Interferon interferons Kinases Lasionycteris noctivagans lethal dose 50 Lyssavirus Mannitol mice Monoclonal antibodies necrosis neoplasms Pathogenesis Rabies Rabies lyssavirus Rabies virus Ribavirin Sorafenib Survival survival rate Targeted cancer therapy therapeutics TNF inhibitors Toxicity tumor necrosis factor-alpha Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors vaccines viral load virus replication Viruses St Louis Missouri United States > US Czech Republic HRIG Infliximab Rabies virus Survival Combination Sorafenib
ISSN:	0264-410X, 1873-2518, 1873-2518
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!