Host range of mammalian orthoreovirus type 3 widening to alpine chamois
•MRV-3 has been identified from lung tissues of alpine chamois in Italian Alps.•Virus belongs to lineage III clustering with strains from dog, bat and diarrheic pig.•Whole genome sequence highlighted reassortment and lack of host specific barriers.•No respiratory symptoms neither lung macroscopic le...
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| Published in: | Veterinary microbiology Vol. 230; pp. 72 - 77 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01.03.2019
Elsevier BV |
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| ISSN: | 0378-1135, 1873-2542, 1873-2542 |
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| Abstract | •MRV-3 has been identified from lung tissues of alpine chamois in Italian Alps.•Virus belongs to lineage III clustering with strains from dog, bat and diarrheic pig.•Whole genome sequence highlighted reassortment and lack of host specific barriers.•No respiratory symptoms neither lung macroscopic lesions were observed.•High seroprevalence was observed in chamois population during a five-years survey.
Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in chamois population during five consecutive years (2008-2012). Three novel MRVs were isolated on cell culture from chamois lung tissues. No respiratory or other clinical symptoms neither lung macroscopic lesions were observed in the chamois population. MRV strains were classified as MRV-3 within the lineage III, based on S1 phylogeny, and were closely related to Italian strains identified in dog, bat and diarrheic pig. The full genome sequence was obtained by next-generation sequencing and phylogenetic analyses showed that other segments were more similar to MRVs of different geographic locations, serotypes and hosts, including human, highlighting genome reassortment and lack of host specific barriers. By using serum neutralization test, a high prevalence of MRV-3 antibodies was observed in chamois population throughout the monitored period, showing an endemic level of infection and suggesting a self-maintenance of MRV and/or a continuous spill-over of infection from other animal species. |
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| AbstractList | Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in chamois population during five consecutive years (2008-2012). Three novel MRVs were isolated on cell culture from chamois lung tissues. No respiratory or other clinical symptoms neither lung macroscopic lesions were observed in the chamois population. MRV strains were classified as MRV-3 within the lineage III, based on S1 phylogeny, and were closely related to Italian strains identified in dog, bat and diarrheic pig. The full genome sequence was obtained by next-generation sequencing and phylogenetic analyses showed that other segments were more similar to MRVs of different geographic locations, serotypes and hosts, including human, highlighting genome reassortment and lack of host specific barriers. By using serum neutralization test, a high prevalence of MRV-3 antibodies was observed in chamois population throughout the monitored period, showing an endemic level of infection and suggesting a self-maintenance of MRV and/or a continuous spill-over of infection from other animal species.Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in chamois population during five consecutive years (2008-2012). Three novel MRVs were isolated on cell culture from chamois lung tissues. No respiratory or other clinical symptoms neither lung macroscopic lesions were observed in the chamois population. MRV strains were classified as MRV-3 within the lineage III, based on S1 phylogeny, and were closely related to Italian strains identified in dog, bat and diarrheic pig. The full genome sequence was obtained by next-generation sequencing and phylogenetic analyses showed that other segments were more similar to MRVs of different geographic locations, serotypes and hosts, including human, highlighting genome reassortment and lack of host specific barriers. By using serum neutralization test, a high prevalence of MRV-3 antibodies was observed in chamois population throughout the monitored period, showing an endemic level of infection and suggesting a self-maintenance of MRV and/or a continuous spill-over of infection from other animal species. •MRV-3 has been identified from lung tissues of alpine chamois in Italian Alps.•Virus belongs to lineage III clustering with strains from dog, bat and diarrheic pig.•Whole genome sequence highlighted reassortment and lack of host specific barriers.•No respiratory symptoms neither lung macroscopic lesions were observed.•High seroprevalence was observed in chamois population during a five-years survey. Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in chamois population during five consecutive years (2008-2012). Three novel MRVs were isolated on cell culture from chamois lung tissues. No respiratory or other clinical symptoms neither lung macroscopic lesions were observed in the chamois population. MRV strains were classified as MRV-3 within the lineage III, based on S1 phylogeny, and were closely related to Italian strains identified in dog, bat and diarrheic pig. The full genome sequence was obtained by next-generation sequencing and phylogenetic analyses showed that other segments were more similar to MRVs of different geographic locations, serotypes and hosts, including human, highlighting genome reassortment and lack of host specific barriers. By using serum neutralization test, a high prevalence of MRV-3 antibodies was observed in chamois population throughout the monitored period, showing an endemic level of infection and suggesting a self-maintenance of MRV and/or a continuous spill-over of infection from other animal species. Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers. Here we report the identification and genetic characterization of MRVs strains in alpine chamois, one of the most abundant wild ungulate in the Alps. Serological survey was also performed by MRV neutralization test in chamois population during five consecutive years (2008-2012). Three novel MRVs were isolated on cell culture from chamois lung tissues. No respiratory or other clinical symptoms neither lung macroscopic lesions were observed in the chamois population. MRV strains were classified as MRV-3 within the lineage III, based on S1 phylogeny, and were closely related to Italian strains identified in dog, bat and diarrheic pig. The full genome sequence was obtained by next-generation sequencing and phylogenetic analyses showed that other segments were more similar to MRVs of different geographic locations, serotypes and hosts, including human, highlighting genome reassortment and lack of host specific barriers. By using serum neutralization test, a high prevalence of MRV-3 antibodies was observed in chamois population throughout the monitored period, showing an endemic level of infection and suggesting a self-maintenance of MRV and/or a continuous spill-over of infection from other animal species. |
| Author | Lauzi, Stefania Lelli, Davide Lavazza, Antonio Chiapponi, Chiara Viganò, Roberto Besozzi, Martina Pisoni, Giuliano Luzzago, Camilla Lanfranchi, Paolo |
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| Copyright | 2019 Elsevier B.V. Copyright © 2019 Elsevier B.V. All rights reserved. Copyright Elsevier BV Mar 2019 |
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| Keywords | Phylogenetic analysis Orthoreovirus Chamois Ruminant Lung Seroprevalence |
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| Snippet | •MRV-3 has been identified from lung tissues of alpine chamois in Italian Alps.•Virus belongs to lineage III clustering with strains from dog, bat and... Mammalian orthoreoviruses (MRV) type 3 have been recently identified in human and several animal hosts, highlighting the apparent lack of species barriers.... |
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| SubjectTerms | Alps region Animals Animals, Wild - virology antibodies blood serum Cell culture Chamois Chiroptera Chiroptera - virology dogs Dogs - virology Feces - virology Female genome Genome, Viral Genomes high-throughput nucleotide sequencing Host range Host Specificity hosts humans Italy - epidemiology Lung Lung - virology lungs Male Mammalian orthoreovirus Mammalian orthoreovirus 3 - genetics Mammalian orthoreovirus 3 - isolation & purification Neutralization Tests Next-generation sequencing Nucleotide sequence nucleotide sequences Orthoreovirus Phylogenetic analysis Phylogeny Reoviridae Infections - epidemiology Reoviridae Infections - veterinary Ruminant Rupicapra - virology Sequence Analysis, DNA Seroepidemiologic Studies Serogroup serological surveys Seroprevalence Serotypes signs and symptoms (animals and humans) swine Swine - virology |
| Title | Host range of mammalian orthoreovirus type 3 widening to alpine chamois |
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